Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Estrogen analogues"'
Publikováno v:
Seminars in Cell & Developmental Biology. 59:126-140
Indiscriminate use of synthetic chemical compounds and the unregulated presence of heavy metals threatens the integral reproducibility of mankind and other living organisms. The toxicity of these compounds far outweighs the usefulness of these compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31197c20bad101f200f7ecbe97202363
https://doi.org/10.1016/j.semcdb.2016.03.024
https://doi.org/10.1016/j.semcdb.2016.03.024
Publikováno v:
Synthesis. 2009:2040-2060
A library of 25 novel estrogen analogues were prepared in five to eight steps from mostly commercially available substituted anisoles via bromination, formylation, Corey―Fuchs reaction, elimination, and Sonogashira reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34b35147e38064f924cf77f9e494962b
https://doi.org/10.1055/s-0029-1216810
https://doi.org/10.1055/s-0029-1216810
Autor:
Gi Jeong Cheon, John A. Katzenellenbogen, Gwang Il An, Dae Yoon Chi, Kyo Chul Lee, Byung Seok Moon
Publikováno v:
Bulletin of the Korean Chemical Society. 29:1107-1114
It is important to identify selective ligands for the estrogen receptor subtypes ERα or ERβ to evaluate them as pharmaceutical targets in breast cancer. To develop ERβ-selective ligands as PET imaging agents, a series of aryl indazole estrogen ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4e08e12004b85d7d48d45eb96f0eb8d
https://doi.org/10.5012/bkcs.2008.29.6.1107
https://doi.org/10.5012/bkcs.2008.29.6.1107
Autor:
Carsten A. Vock, Ilga K. Krimmelbein, Christiane Gatz, Kazi Mohammed Didarul Islam, J. Matthias Wiegand, Linda Nacke, Lutz F. Tietze, Tokala Ramachandar
Publikováno v:
Chemistry - A European Journal. 14:3670-3679
A library of 17 novel estrogen analogues 3 and 4 containing different substituents at rings A and D (steroid nomenclature) was prepared in a five- to seven-step synthesis. The key transformation is a Sonogashira-coupling of cyclic vinyl iodides of ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42105f08d0458bd3bd2d6ddee66eabc6
https://doi.org/10.1002/chem.200701600
https://doi.org/10.1002/chem.200701600
Autor:
T. R. Boronoeva, A. G. Shavva, V. G. Isaeva, B. P. Surinov, Galina L. Starova, A. N. Sharetskii, I. A. Gluzdikov, I. V. Ishchenko, Stanislav I. Selivanov
Publikováno v:
Russian Journal of Bioorganic Chemistry. 28:215-223
The study of the binding of estradiol B-nor-8-isonalogues to estrogen receptors from the rat uterus helped create the proposed model of the corresponding ligand–receptor complexes. The use of this model ensured the choice of such micromodifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a81a4cbdd14cb1bc1771a78ad8a1fd8
https://doi.org/10.1023/a:1015708404708
https://doi.org/10.1023/a:1015708404708
Publikováno v:
Journal of the American Chemical Society. 120:8971-8977
An novel efficient catalytic approach to steroids by a double Heck reaction of the vinyl bromides 2 and the CD-building block 3 is presented. The new estrogen analogues 1a and 1b are formed via 23a...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d7bf8df8c5572b90625f9a6e48ded01
https://doi.org/10.1021/ja981539o
https://doi.org/10.1021/ja981539o
Autor:
Claus Christiansen
Publikováno v:
Journal SOGC. 17:1222-1227
In the future, attention must be directed to possible means of preventing and treating osteoporosis. However, prevention and treatment have to be preceded by diagnosis and it is, therefore, of the greatest importance that available diagnostic possibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f32b71b1f96e6b08bde07d11a7ac09f
https://doi.org/10.1016/s1701-2163(16)30565-5
https://doi.org/10.1016/s1701-2163(16)30565-5
Publikováno v:
Steroids-Basic Science
Estrogens play a key role in multiple physiological functions in women. They have important actions on bone and lipid metabolism, cardiovascular function, and diffuse effects on other target organs. Estrogens have important roles in cognitive functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8551368f8bb9a7e2edb10f369747ffce
https://doi.org/10.5772/26432
https://doi.org/10.5772/26432
Publikováno v:
ChemInform. 22
C20H24O4, Mr = 328.41, orthorhombic, P2(1)2(1)2(1), a = 11.688 (3), b = 15.377 (5), c = 9.466 (2) A, V = 1701 (1) A3, Z = 4, Dx = 1.282 g cm-3, lambda (Mo K alpha) = 0.71073 A, mu = 0.823 cm-1, F(000) = 704, T = 298 K, R = 0.063 for 1921 reflections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::701d8c91ef79cd9d954ef8d47c23dbf4
https://doi.org/10.1002/chin.199133253
https://doi.org/10.1002/chin.199133253
Publikováno v:
ChemInform. 30
The use of high throughput screening (HTS) to identify lead compounds has greatly challenged conventional quantitative structure-activity relationship (QSAR) techniques that typically correlate structural variations in similar compounds with continuo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2950aa21340ee17ae69e183183255bf6
https://doi.org/10.1002/chin.199921263
https://doi.org/10.1002/chin.199921263