Výsledky vyhledávání - "Estrogen Receptor alpha/genetics"

Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium

Autor: Cagnet, Stéphanie, Ataca, Dalya, Sflomos, George, Aouad, Patrick, Schuepbach-Mallepell, Sonia, Hugues, Henry, Krust, Andrée, Ayyanan, Ayyakkannu, Scabia, Valentina, Brisken, Cathrin

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature communications, vol. 9, no. 1, pp. 4723
Nature Communications
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-07175-0⟩

Oestrogen receptor α (ERα) is a transcription factor with ligand-independent and ligand-dependent activation functions (AF)-1 and -2. Oestrogens control postnatal mammary gland development acting on a subset of mammary epithelial cells (MECs), term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::37eac31573f29d80222640b3da063824
http://link.springer.com/article/10.1038/s41467-018-07175-0

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Estrogen Receptor on the move: Cistromic plasticity and its implications in breast cancer

Autor: Wilbert Zwart, Isabel Mayayo-Peralta, Stefan Prekovic

Publikováno v: Molecular Aspects of Medicine, 78:100939. Elsevier

Estrogen Receptor (ERα) is a hormone-driven transcription factor, critically involved in driving tumor cell proliferation in the vast majority of breast cancers (BCas). ERα binds the genome at cis-regulatory elements, dictating the expression of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622b51f591826ab3060b0c11a783adc3
https://doi.org/10.1016/j.mam.2020.100939

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The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure

Autor: Yu Teng Lee, Nicholas W. Wood, Richard S. J. Frackowiak, Clarence Chih King Tan, Geoffrey Tan, Carlton Chu, John Ashburner

Publikováno v: NeuroImage, vol. 221, pp. 117087
NeuroImage, Vol 221, Iss, Pp 117087-(2020)

The androgen receptor (AR), oestrogen receptor alpha (ESR1) and oestrogen receptor beta (ESR2) play essential roles in mediating the effect of sex hormones on sex differences in the brain. Using Voxel-based morphometry (VBM) and gene sizing in two in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564ec607ad6a1113a57f0c3ab3106af0
https://doi.org/10.1016/j.neuroimage.2020.117087

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SNAI2 upregulation is associated with an aggressive phenotype in fulvestrant-resistant breast cancer cells and is an indicator of poor response to endocrine therapy in estrogen receptor-positive metastatic breast cancer

Autor: Henrik J. Ditzel, Daniel Elias, Martin Bak, Maria Bibi Lyng, Carla Maria Lourenco Alves

Publikováno v: Alves, C M L, Elias, D, Lyng, M B, Bak, M & Ditzel, H 2018, ' SNAI2 upregulation is associated with an aggressive phenotype in fulvestrant-resistant breast cancer cells and is an indicator of poor response to endocrine therapy in estrogen receptor-positive metastatic breast cancer ', Breast Cancer Research, vol. 20, 60 . https://doi.org/10.1186/s13058-018-0988-9
Breast Cancer Research : BCR
Breast Cancer Research, Vol 20, Iss 1, Pp 1-12 (2018)

Background Endocrine resistance in estrogen receptor-positive (ER+) breast cancer is a major clinical problem and is associated with accelerated cancer cell growth, increased motility and acquisition of mesenchymal characteristics. However, the speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9d7f336d2ff1a7d80a2e5a31621b6d
https://findresearcher.sdu.dk:8443/ws/files/141819899/Alves_et_al_2018_Breast_Cancer_Research.pdf

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Williams syndrome transcription factor (WSTF) acts as an activator of estrogen receptor signaling in breast cancer cells and the effect can be abrogated by 1α,25-dihydroxyvitamin D3

Autor: Anne Katrine Duun-Henriksen, Anne E. Lykkesfeldt, Martin Bak, Johan Lundqvist, Tove Kirkegaard, David Feldman, Anne Vibeke Lænkholm

Publikováno v: Lundqvist, J, Kirkegaard, T, Laenkholm, A V, Duun-Henriksen, A K, Bak, M, Feldman, D & Lykkesfeldt, A E 2018, ' Williams syndrome transcription factor (WSTF) acts as an activator of estrogen receptor signaling in breast cancer cells and the effect can be abrogated by 1α,25-dihydroxyvitamin D 3 ', Journal of Steroid Biochemistry and Molecular Biology, vol. 177, pp. 171-178 . https://doi.org/10.1016/j.jsbmb.2017.06.003

A majority of estrogen receptor positive (ER+) breast cancers are growth stimulated by estrogens. The ability to inhibit the ER signaling pathway is therefore of critical importance in the current treatment of ER+ breast cancers. It has been reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b37f81a115905364460c978cfcad7a
https://portal.findresearcher.sdu.dk/da/publications/4d69951e-66e0-49e2-894c-3aad70d9ee69

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Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170

Autor: Jirong Long, Simon S. Cross, Marc Tischkowitz, Beth Y. Karlan, Trinidad Caldés, Fergus J. Couch, Charlotte Sagne, Ute Hamann, Olga M. Sinilnikova, Maria Kabisch, Richard C Sallari, Gad Rennert, Daniel Barrowdale, Elinor J. Sawyer, Anthony J. Swerdlow, Jenny Lester, Åke Borg, Anders Bojesen, Rosa B. Barkardottir, Simon A. Gayther, Heli Nevanlinna, Judy Garber, Norbert Arnold, Vilde Drageset Haakensen, Vessela N. Kristensen, Christopher G. Scott, Daehee Kang, Gillian Mitchell, Eitan Friedman, Laura Ottini, Diether Lambrechts, Manjeet K. Bolla, Robert L. Nussbaum, Tomasz Huzarski, Dieter Niederacher, Angela Cox, Rachel Laframboise, Maartje J. Hooning, Volker Arndt, Penny Soucy, Marjanka K. Schmidt, William Blot, Soo Hwang Teo, Anne Lise Børresen-Dale, Maria A. Caligo, Ana Osorio, Orland Diez, Gertraud Maskarinec, Johanna Rantala, Kelly-Anne Phillips, Pascal Guénel, Hidemi Ito, Miquel Angel Pujana, Anna H. Wu, Christy G. Woolcott, Maya Ghoussaini, Hatef Darabi, Sander Canisius, Kay-Tee Khaw, Irene Konstantopoulou, Carl Blomqvist, Christine Rappaport, Joan Brunet, Hermann Brenner, Sylvie Mazoyer, Irene L. Andrulis, Nicholas A Sinnott-Armstrong, Javier Benitez, Claudine Isaacs, Mahdi Moradi Marjaneh, Joseph Vijai, Jennifer Stone, Qin Wang, Caroline Seynaeve, Patricia A. Ganz, Sara Margolin, Paolo Radice, Janet E. Olson, Soo-Chin Lee, Mark H. Greene, Laura Papi, Carmel Apicella, Ava Kwong, Mitul Shah, Matthias W. Beckmann, Yael Laitman, Hoda Anton-Culver, Ans M.W. van den Ouweland, Sue K. Park, Annegien Broeks, Georgia Chenevix-Trench, Jonathan Beesley, Nadja Bogdanova-Markov, Paolo Peterlongo, Paraskevi Apostolou, Bernardo Bonanni, Frederik Marmé, Veli-Matti Kosma, Alfons Meindl, Brian E. Henderson, Rulla M. Tamimi, Siranoush Manoukian, Bent Ejlertsen, Miroslav Kapuscinski, Juliet D. French, Mark E. Sherman, Ji Yeob Choi, Graham G. Giles, Stacey L. Edwards, Evgeny N. Imyanitov, Kamila Czene, Thomas Hansen, Nick Orr, Susanne Kaufmann, Lenka Foretova, Celine M. Vachon, Edith Olah, Anja Rudolph, Arto Mannermaa, Phuong L. Mai, Isabel dos-Santos-Silva, Haran Sivakumaran, Francesca Damiola, Christian F. Singer, Muhammad Usman Rashid, Ed Dicks, Mikael Hartman, Antonis C. Antoniou, Dominique Stoppa-Lyonnet, Douglas F. Easton, Alison M. Dunning, John L. Hopper, Nadine Tung, Annika Lindblom, Kristiina Aittomäki, Kenneth Muir, Sue Healey, Cheng Har Yip, Mads Thomassen, Melissa C. Southey, Ramunas Janavicius, Cecilia M. Dorfling, Christine B. Ambrosone, Siddhartha Kar, Mary B. Daly, Artitaya Lophatananon, Rachel Rando, Banu Arun, Christopher A. Haiman, Catherine M. Phelan, Margaret Hills, Manuel R. Teixeira, Diana Torres, Hans Wildiers, Andrew K. Godwin, Keith Humphreys, Katri Pylkäs, Monika Jarosz, Susan L. Neuhausen, Montserrat Garcia-Closas, Robert Winqvist, Joe Dennis, Sook-Yee Yoon, Wei Zheng, Mitch Dowsett, Gord Glendon, Natasha Bogdanova, Suleeporn Sangrajrang, Steve Ellis, Paul Brennan, Lee Eunjung, Keitaro Matsuo, Jacek Gronwald, David E. Goldgar, Debra Frost, Chiu-Chen Tseng, Henrik Flyger, Kristine M. Hillman, Susan M. Domchek, Elena Lopez-Knowles, Bernard Peissel, Anna von Wachenfeldt, Karoline Kuchenbaecker, Anna Jakubowska, Paul D.P. Pharoah, Jose Ignacio Arias Perez, Kim De Leeneer, Roger L. Milne, Peter A. Fasching, Louise Izatt, Saundra S. Buys, Lesley McGuffog, Elizabeth J. van Rensburg, Pei-Ei Wu, Peter Devilee, Åslaug Helland, Qiuyin Cai, Peter J. Hulick, Miguel de la Hoya, Esther M. John, Kerstin Rhiem, Jan Lubinski, Karen A. Pooley, Marion Piedmonte, Catherine S. Healey, Mark S. Goldberg, Xiao-Ou Shu, Antoinette Hollestelle, Mary Beth Terry, Jenny Chang-Claude, Silje Nord, Chen-Yang Shen, Hiltrud Brauch, Kathleen Claes, Jason Sang Hun Lee, Sofia Khan, Katherine L. Nathanson, Hans Ehrencrona, Olufunmilayo I. Olopade, Stig E. Bojesen, Matti A. Rookus, Andrew Lee, Rita K. Schmutzler, Julian Peto, Jeffrey N. Weitzel, Barbara Burwinkel, Arjen R. Mensenkamp, Jacques Simard, Yu-Tang Gao, Robert Luben, S. Drury, Thilo Dörk, Laima Tihomirova, Per Hall, Barbara Perkins, Simona Agata, Jonine D. Figueroa, Julia A. Knight, Kenneth Offit, Kyriaki Michailidou, Anna González-Neira, Ian Tomlinson, Thérèse Truong, Amanda E. Toland, Anna Marie Mulligan, Noralane M. Lindor, Deborah J. Thompson, Marco Montagna

Publikováno v: Nature Genetics, 48(4), 374-386. Nature Publishing Group
Nature Genetics, 48(4), 374
Dunning, A M, Michailidou, K, Kuchenbaecker, K B, Thompson, D J, French, J D, Beesley, J, Healey, C S, Kar, S, Pooley, K A, Lopez-Knowles, E, Dicks, E, Barrowdale, D, Sinnott-Armstrong, N A, Sallari, R C, Hillman, K M, Kaufmann, S, Sivakumaran, H, Moradi Marjaneh, M, Lee, J S, Hills, M, Jarosz, M, Drury, S, Canisius, S, Bolla, M K, Dennis, J, Wang, Q, Hopper, J L, Southey, M C, Broeks, A, Schmidt, M K, Lophatananon, A, Muir, K, Beckmann, M W, Fasching, P A, Dos Santos Silva, I, Peto, J, Sawyer, E J, Tomlinson, I, Burwinkel, B, Marme, F, Guénel, P, Truong, T, Bojesen, S E, Flyger, H, González-Neira, A, Perez, J I A, Shen, C-Y, Hansen, T V O, Bojesen, A, Thomassen, M & EMBRACE 2016, ' Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 ', Nature Genetics, vol. 48, no. 4, pp. 374-386 . https://doi.org/10.1038/ng.3521
Nature Genetics, 48(4), 374-+. Nature Publishing Group
Recercat. Dipósit de la Recerca de Catalunya
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Dipòsit Digital de la UB
Universidad de Barcelona
Dunning, A M, Michailidou, K, Kuchenbaecker, K B, Thompson, D, French, J D, Beesley, J, Healey, C S, Kar, S, Pooley, K A, Lopez-Knowles, E, Dicks, E, Barrowdale, D, Sinnott-Armstrong, N A, Sallari, R C, Hillman, K M, Kaufmann, S, Sivakumaran, H, Moradi Marjaneh, M, Lee, J S, Hills, M, Jarosz, M, Drury, S, Canisius, S, Bolla, M K, Dennis, J, Wang, Q, Hopper, J L, Southey, M C, Broeks, A, Schmidt, M K, Lophatananon, A, Muir, K, Beckmann, M W, Fasching, P A, Dos-Santos-Silva, I, Peto, J, Sawyer, E J, Tomlinson, I, Burwinkel, B, Marme, F, Guénel, P, Truong, T, Bojesen, S E, Flyger, H, González-Neira, A & Perez, J I A & Anton-Culver, H & Eunjung, L & Arndt, V & Figueroa, J 2016, ' Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 ', Nature Genetics, vol. 48, no. 4, pp. 374-386 . https://doi.org/10.1038/ng.3521
Nature Genetics, 48, 374-86
Nature Genetics, 48, 4, pp. 374-86

To access publisher's full text version of this article click on the hyperlink at the bottom of the page We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor α) in 118,816 subjects from three international cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9243da2133c0ff63e63cff70cb87aac9
https://hdl.handle.net/1887/113197

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Estrogen Receptor α Polymorphism and Risk of Cardiovascular Disease, Cancer, and Hip Fracture

Autor: Marie-Louise M. Grønholdt, Anne Tybjærg-Hansen, Alisa D. Kjaergaard, Christina Ellervik, Børge G. Nordestgaard, C K Axelsson, Gorm B. Jensen, Peer Grande

Publikováno v: Kjaergaard, A D, Ellervik, C, Tybjaerg-Hansen, A, Axelsson, C K, Grønholdt, M-L M, Grande, P, Jensen, G B & Nordestgaard, B G 2007, ' Estrogen receptor alpha polymorphism and risk of cardiovascular disease, cancer, and hip fracture: cross-sectional, cohort, and case-control studies and a meta-analysis ', Circulation, vol. 115, no. 7, pp. 861-71 . https://doi.org/10.1161/CIRCULATIONAHA.106.615567

Background— We hypothesized that the estrogen receptor α (ESR1) IVS1-397T/C polymorphism affects high-density lipoprotein cholesterol response to hormone replacement therapy and risk of cardiovascular disease (CVD), cancer of reproductive organs,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1df3eaaafabc91079170079fd982841
https://doi.org/10.1161/circulationaha.106.615567

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Exploration of gene-environment interactions, maternal effects and parent of origin effects in the etiology of hypospadias

Autor: Min Shi, Marijn M. Brouwers, Tessel E. Galesloot, Wout F.J. Feitz, Nine V A M Knoers, Barbara Franke, Nel Roeleveld, Loes F.M. van der Zanden, Iris A.L.M. van Rooij

Publikováno v: Journal of Urology, 188, 6, pp. 2354-60
Journal of Urology, 188, 2354-60
Journal of Urology, 188(6), 2354-2360. LIPPINCOTT WILLIAMS & WILKINS

Contains fulltext : 107835.pdf (Author’s version preprint ) (Open Access) PURPOSE: Hypospadias is a common congenital malformation of the male external genitalia. Association studies for single nucleotide polymorphisms in genes encoding steroid 5al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef335fc9139fd32160a430aedd0915fb
https://hdl.handle.net/2066/107835

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