Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Estrella Nuñez Delicado"'
Autor:
Fumiyuki Hatanaka, Keiichiro Suzuki, Kensaku Shojima, Jingting Yu, Yuta Takahashi, Akihisa Sakamoto, Javier Prieto, Maxim Shokhirev, Estrella Nuñez Delicado, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmonte
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Defect in the SMN1 gene causes spinal muscular atrophy (SMA), which shows loss of motor neurons, muscle weakness and atrophy. While current treatment strategies, including small molecules or viral vectors, have shown promise in improving mot
Externí odkaz:
https://doaj.org/article/10b9828b196546fa8165e5097af9a12a
Autor:
Haisong Liu, Ronghui Li, Hsin-Kai Liao, Zheying Min, Chao Wang, Yang Yu, Lei Shi, Jiameng Dan, Alberto Hayek, Llanos Martinez Martinez, Estrella Nuñez Delicado, Juan Carlos Izpisua Belmonte
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Human pluripotent stem cell (hPSC) derived pancreatic beta cells are a promising and potentially limitless source for cell replacement therapy. Here the authors perform stage-wise chemical screening to develop an improved protocol for hPSC differenti
Externí odkaz:
https://doaj.org/article/e0538b6a302e489391b9de003c23bba8
Autor:
Chao Wang, Ruben Rabadan Ros, Paloma Martinez-Redondo, Zaijun Ma, Lei Shi, Yuan Xue, Isabel Guillen-Guillen, Ling Huang, Tomoaki Hishida, Hsin-Kai Liao, Estrella Nuñez Delicado, Concepcion Rodriguez Esteban, Pedro Guillen-Garcia, Pradeep Reddy, Juan Carlos Izpisua Belmonte
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Short term systemic expression of the reprogramming factors Oct-3/4, Sox2, Klf4, c-Myc (OSKM) rejuvenates aging cells and promotes tissue regeneration. Here the authors show that myofiber-specific expression of OSKM accelerates muscle regeneration by
Externí odkaz:
https://doaj.org/article/ec46029f8e914da49e6eeddd4f0bc4ed
Autor:
Tomoaki Hishida, Eric Vazquez-Ferrer, Yuriko Hishida-Nozaki, Yuto Takemoto, Fumiyuki Hatanaka, Kei Yoshida, Javier Prieto, Sanjeeb Kumar Sahu, Yuta Takahashi, Pradeep Reddy, David D. O’Keefe, Concepcion Rodriguez Esteban, Paul S. Knoepfler, Estrella Nuñez Delicado, Antoni Castells, Josep M. Campistol, Ryuji Kato, Hiroshi Nakagawa, Juan Carlos Izpisua Belmonte
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewa
Externí odkaz:
https://doaj.org/article/31205045cd044c04b4a97467e784b2c0
Autor:
Pradeep Reddy, Yanjiao Shao, Reyna Hernandez-Benitez, Estrella Nuñez Delicado, Juan Carlos Izpisua Belmonte
Publikováno v:
Protein & Cell, Vol 11, Iss 12, Pp 862-865 (2020)
Externí odkaz:
https://doaj.org/article/50820a677a3c41b78a90f1366218da38
Autor:
Naresh Mutukula, Zhiqiu Man, Yuta Takahashi, Francisca Iniesta Martinez, Mariana Morales, Ester Carreon-Guarnizo, Rocio Hernandez Clares, David Garcia-Bernal, Llanos Martinez Martinez, Jeronimo Lajara, Estrella Nuñez Delicado, Jose E. Meca Lallana, Juan Carlos Izpisua Belmonte
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102319- (2021)
The advent of cellular reprogramming technology converting somatic cells into induced pluripotent stem cells (iPSCs) has revolutionized our understandings of neurodegenerative diseases that are otherwise hard to access and model. Multiple Sclerosis (
Externí odkaz:
https://doaj.org/article/d21d3e405f6f458782cb80a7ba2f08a9
Autor:
Tomoaki Hishida, Eric Vazquez-Ferrer, Yuriko Hishida-Nozaki, Ignacio Sancho-Martinez, Yuta Takahashi, Fumiyuki Hatanaka, Jun Wu, Alejandro Ocampo, Pradeep Reddy, Min-Zu Wu, Laurie Gerken, Reuben J. Shaw, Concepcion Rodriguez Esteban, Christopher Benner, Hiroshi Nakagawa, Pedro Guillen Garcia, Estrella Nuñez Delicado, Antoni Castells, Josep M. Campistol, Guang-Hui Liu, Juan Carlos Izpisua Belmonte
Publikováno v:
Protein & Cell, Vol 10, Iss 7, Pp 485-495 (2019)
Abstract Identification of the precise molecular pathways involved in oncogene-induced transformation may help us gain a better understanding of tumor initiation and promotion. Here, we demonstrate that SOX2+ foregut epithelial cells are prone to onc
Externí odkaz:
https://doaj.org/article/650bfe1468004174b4f346e6bcc81813
Autor:
Fumiyuki Hatanaka, Keiichiro Suzuki, Kensaku Shojima, Jingting Yu, Yuta Takahashi, Akihisa Sakamoto, Javier Prieto, Maxim Shokhirev, Concepcion Rodriguez Esteban, Estrella Nuñez-Delicado, Juan Carlos Izpisua Belmonte
Defect in theSMN1gene causes spinal muscular atrophy (SMA), which shows loss of motor nerve cells, muscle weakness and atrophy. While current treatment strategies, including small molecules or viral vectors, have been reported to improve motor functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1704ae05f8e35f427a0520dee22084c8
https://doi.org/10.1101/2023.04.06.535786
https://doi.org/10.1101/2023.04.06.535786
Autor:
Kristen C. Browder, Pradeep Reddy, Mako Yamamoto, Amin Haghani, Isabel Guillen Guillen, Sanjeeb Sahu, Chao Wang, Yosu Luque, Javier Prieto, Lei Shi, Kensaku Shojima, Tomoaki Hishida, Zijuan Lai, Qingling Li, Feroza K. Choudhury, Weng R. Wong, Yuxin Liang, Dewakar Sangaraju, Wendy Sandoval, Concepcion Rodriguez Esteban, Estrella Nuñez Delicado, Pedro Guillen Garcia, Michal Pawlak, Jason A. Vander Heiden, Steve Horvath, Heinrich Jasper, Juan Carlos Izpisua Belmonte
Publikováno v:
Nature Aging. 2:243-253
Autor:
Dalia Raïch-Regué, Raquel Tenorio, Isabel Fernández de Castro, Daniel Perez -Zsolt, Jordana Muñoz-Basagoiti, Martin Sachse, Sara Y. Fernández-Sánchez, Marçal Gallemí, Paula Ortega-González, Alberto Fernández-Oliva, José A. Gabaldón, Estrella Nuñez-Delicado, Josefina Casas, Ferran Tarrés, Júlia-Vergara Alert, Joaquim Segalés, Jorge Carillo, Julià Blanco, Bonaventura Clotet Sala, José P. Cerón-Carrasco, Nuria Izquierdo-Useros, Cristina Risco
The SARS-CoV-2 pandemic made evident that we count with few coronavirus-fighting drugs. Here we aimed to identify a cost-effective antiviral with broad spectrum activity and high safety and tolerability profiles. We began elaborating a list of 116 dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df00b9afd6fa5ee17c3a588fabdfeef
https://doi.org/10.1101/2022.11.16.516726
https://doi.org/10.1101/2022.11.16.516726