Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors

Autor: Lina Zhang, Fenju Wei, David Borrego, Fabao Zhao, Javier Martínez del Río, Estrella Frutos-Beltrán, Jiwei Zhang, Shujing Xu, Nerea López-Carrobles, Shenghua Gao, Dongwei Kang, Christophe Pannecouque, Erik De Clercq, Xinyong Liu, Luis Menéndez-Arias, Peng Zhan

Publikováno v: European Journal of Medicinal Chemistry. 240:114563

Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated ribonuclease H (RNase H) remains as the only enzyme encoded within the viral genome not clinically validated as an antiviral target. We have previously reported that the galloyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96ac12a39cfbe61da9e6f9874d9ac18
https://doi.org/10.1016/j.ejmech.2022.114563

Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors

Autor: Mar Álvarez, Christophe Pannecouque, Peng Zhan, Fenju Wei, Estrella Frutos-Beltrán, Erik De Clercq, Lin Sun, Luis Menéndez-Arias, Yucen Tao, Da Feng, Xinyong Liu, Çagil Urhan, Dongwei Kang

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Despite significant advances in antiretroviral therapy, acquired immunodeficiency syndrome remains as one of the leading causes of death worldwide. New antiretroviral drugs combined with updated treatment strategies are needed to improve convenience,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b10189f6534a99bdd33f0bd6f856798
https://pubmed.ncbi.nlm.nih.gov/34403976

An Update on Antiretroviral Therapy

Autor: Samara Martín-Alonso, Luis Menéndez-Arias, Estrella Frutos-Beltrán

Publikováno v: Antiviral Drug Discovery and Development ISBN: 9789811602665

Human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) still claim many lives across the world. However, research efforts during the last 40 years have led to the approval of over 30 antiretroviral drugs and the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fc4e9755c944bc0b7d30990b8c2f3b2
https://doi.org/10.1007/978-981-16-0267-2_2

Reverse Transcriptase: From Transcriptomics to Genome Editing

Autor: Luis Menéndez-Arias, Estrella Frutos-Beltrán, Samara Martín-Alonso

Publikováno v: Trends in biotechnology. 39(2)

Reverse transcriptases (RTs) are enzymes that can generate a complementary strand of DNA (cDNA) from RNA. Coupled with PCR, RTs have been widely used to detect RNAs and to clone expressed genes. Classical retroviral RTs have been improved by protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce39ccbabb79e350c0345c47b31969be
https://pubmed.ncbi.nlm.nih.gov/32653101

Key Role of the Local Hydrophobicity in the East Patch of Plastocyanins on Their Thermal Stability and Redox Properties

Autor: Inmaculada Márquez, Miguel A. De la Rosa, Antonio Díaz-Quintana, Estrella Frutos-Beltrán, Juan José Calvente, Irene Díaz-Moreno, José Luis Olloqui-Sariego, Rafael Andreu

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
ACS Omega
idUS. Depósito de Investigación de la Universidad de Sevilla
ACS Omega, Vol 3, Iss 9, Pp 11447-11454 (2018)

Understanding the molecular basis of the thermal stability and functionality of redox proteins has important practical applications. Here, we show a distinct thermal dependence of the spectroscopic and electrochemical properties of two plastocyanins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd71364e91c182fd39a05ea3cb50da98
http://hdl.handle.net/10261/173163