Tracking protein-protein interactions by NMR: conformational selection in human steroidogenic cytochrome P450 CYP17A1 induced by cytochrome b 5 .

Autor: Richard AM; Chemical Biology Program, University of Michigan, Ann Arbor, MI 48109, USA., Estrada DF; Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA., Flynn L; Department of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454-9110, USA. pochapsk@brandeis.edu., Pochapsky SS; Department of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454-9110, USA. pochapsk@brandeis.edu., Scott EE; Chemical Biology Program, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA.; Departments of Medicinal Chemistry, Pharmacology, and Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA., Pochapsky TC; Department of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454-9110, USA. pochapsk@brandeis.edu.; Department of Biochemistry and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South St., Waltham, MA 02454-9110, USA.

Publikováno v: Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2024 Jun 19; Vol. 26 (24), pp. 16980-16988. Date of Electronic Publication: 2024 Jun 19.

Interactions of human mitochondrial Ferredoxin 1 (Adrenodoxin) by NMR; modulation by cytochrome P450 substrate and by truncation of the C-terminal tail.

Autor: Jay N; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA. Electronic address: njay@buffalo.edu., McGlohon JE; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA. Electronic address: janiemcg@buffalo.edu., Estrada DF; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA. Electronic address: dfestrad@buffalo.edu.

Publikováno v: Journal of inorganic biochemistry [J Inorg Biochem] 2023 Dec; Vol. 249, pp. 112370. Date of Electronic Publication: 2023 Sep 12.

Active Site Aromatic Residues Play a Dual Role in the Substrate Interaction and Protein Structure in Functional Dimers of CYP121A1 of Mycobacterium tuberculosis .

Autor: Campomizzi CS; Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, New York 14203, United States., Kumar A; Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, New York 14203, United States., Uttamrao PP; Department of Biotechnology, Indian Institute of Technology Hyderbad, Kandi, Sangareddy, Telangana 502284, India., Stallone JJ; Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, New York 14203, United States., Ghanatios GE; Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, New York 14203, United States., Rathinavelan T; Department of Biotechnology, Indian Institute of Technology Hyderbad, Kandi, Sangareddy, Telangana 502284, India., Estrada DF; Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, New York 14203, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2023 Apr 14; Vol. 9 (4), pp. 827-839. Date of Electronic Publication: 2023 Mar 28.

Characterization of a Cleavable Fusion of Human CYP24A1 with Adrenodoxin Reveals the Variable Role of Hydrophobics in Redox Partner Binding.

Autor: Jay N; Department of Biochemistry, University at Buffalo, Buffalo, New York 14203, United States., Duffy SR; Department of Biochemistry, University at Buffalo, Buffalo, New York 14203, United States., Estrada DF; Department of Biochemistry, University at Buffalo, Buffalo, New York 14203, United States.

Publikováno v: Biochemistry [Biochemistry] 2022 Jan 18; Vol. 61 (2), pp. 57-66. Date of Electronic Publication: 2022 Jan 03.

Surface hydrophobics mediate functional dimerization of CYP121A1 of Mycobacterium tuberculosis.

Autor: Kumar A; Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, NY, 14203, USA., Campomizzi CS; Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, NY, 14203, USA., Jay N; Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, NY, 14203, USA., Ferguson S; Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, NY, 14203, USA., Scheffler EJ; Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, NY, 14203, USA., Lioi J; Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, NY, 14203, USA., Tu C; Department of Pharmaceutical Sciences, School of Pharmacy, University at Buffalo, Buffalo, NY, 14214, USA., Qu J; Department of Pharmaceutical Sciences, School of Pharmacy, University at Buffalo, Buffalo, NY, 14214, USA., Simons C; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK., Estrada DF; Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, NY, 14203, USA. dfestrad@buffalo.edu.

Publikováno v: Scientific reports [Sci Rep] 2021 Jan 11; Vol. 11 (1), pp. 394. Date of Electronic Publication: 2021 Jan 11.