Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Esti Yeger-Lotem"'
Autor:
Chanan M Argov, Ariel Shneyour, Juman Jubran, Eric Sabag, Avigdor Mansbach, Yair Sepunaru, Emmi Filtzer, Gil Gruber, Miri Volozhinsky, Yuval Yogev, Ohad Birk, Vered Chalifa-Caspi, Lior Rokach, Esti Yeger-Lotem
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 11, Pp 1187-1206 (2024)
Abstract Pathogenic variants underlying Mendelian diseases often disrupt the normal physiology of a few tissues and organs. However, variant effect prediction tools that aim to identify pathogenic variants are typically oblivious to tissue contexts.
Externí odkaz:
https://doaj.org/article/cce44c2848284aec9111536ddf3e1a44
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/11c5da74f4b346788f1f6ff586bdb26a
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-29 (2024)
Abstract Background Aneuploidy, an abnormal number of chromosomes within a cell, is a hallmark of cancer. Patterns of aneuploidy differ across cancers, yet are similar in cancers affecting closely related tissues. The selection pressures underlying a
Externí odkaz:
https://doaj.org/article/d69169ed120845ad84a74730e94ffef4
Autor:
Gil Sorek, Yulia Haim, Vered Chalifa-Caspi, Or Lazarescu, Maya Ziv-Agam, Tobias Hagemann, Pamela Arielle Nono Nankam, Matthias Blüher, Idit F. Liberty, Oleg Dukhno, Ivan Kukeev, Esti Yeger-Lotem, Assaf Rudich, Liron Levin
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110368- (2024)
Summary: Deconvolution algorithms mostly rely on single-cell RNA-sequencing (scRNA-seq) data applied onto bulk RNA-sequencing (bulk RNA-seq) to estimate tissues’ cell-type composition, with performance accuracy validated on deposited databases. Adi
Externí odkaz:
https://doaj.org/article/120ff37dd2ea4aedb2a1d37c407109f6
Publikováno v:
eLife, Vol 13 (2024)
Mendelian diseases tend to manifest clinically in certain tissues, yet their affected cell types typically remain elusive. Single-cell expression studies showed that overexpression of disease-associated genes may point to the affected cell types. Her
Externí odkaz:
https://doaj.org/article/d00a8e20aff247e0ae80199a85eda7c7
Predicting molecular mechanisms of hereditary diseases by using their tissue‐selective manifestation
Autor:
Eyal Simonovsky, Moran Sharon, Maya Ziv, Omry Mauer, Idan Hekselman, Juman Jubran, Ekaterina Vinogradov, Chanan M Argov, Omer Basha, Lior Kerber, Yuval Yogev, Ayellet V Segrè, Hae Kyung Im, GTEx Consortium, Ohad Birk, Lior Rokach, Esti Yeger‐Lotem
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 8, Pp 1-20 (2023)
Abstract How do aberrations in widely expressed genes lead to tissue‐selective hereditary diseases? Previous attempts to answer this question were limited to testing a few candidate mechanisms. To answer this question at a larger scale, we develope
Externí odkaz:
https://doaj.org/article/2f83bd8335064584b8465fdd36d265bc
Autor:
Tatiana Tiago, Barbara Hummel, Federica F. Morelli, Valentina Basile, Jonathan Vinet, Veronica Galli, Laura Mediani, Francesco Antoniani, Silvia Pomella, Matteo Cassandri, Maria Giovanna Garone, Beatrice Silvestri, Marco Cimino, Giovanna Cenacchi, Roberta Costa, Vincent Mouly, Ina Poser, Esti Yeger-Lotem, Alessandro Rosa, Simon Alberti, Rossella Rota, Anat Ben-Zvi, Ritwick Sawarkar, Serena Carra
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-19 (2021)
Abstract One of the critical events that regulates muscle cell differentiation is the replacement of the lamin B receptor (LBR)-tether with the lamin A/C (LMNA)-tether to remodel transcription and induce differentiation-specific genes. Here, we repor
Externí odkaz:
https://doaj.org/article/0cc422533b6e43feaa940a5cd07be56b
Autor:
Netta Shemesh, Juman Jubran, Shiran Dror, Eyal Simonovsky, Omer Basha, Chanan Argov, Idan Hekselman, Mehtap Abu-Qarn, Ekaterina Vinogradov, Omry Mauer, Tatiana Tiago, Serena Carra, Anat Ben-Zvi, Esti Yeger-Lotem
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Tissue-specific differences in protein folding capacities are poorly understood. Here, the authors show that the human chaperone system consists of ubiquitous core chaperones and tissue-specific variable chaperones, perturbation of which leads to tis
Externí odkaz:
https://doaj.org/article/b6aba57ae59741e89406ba11b3f77eab
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 4024-4032 (2020)
Hereditary diseases and complex traits often manifest in specific tissues, whereas their causal genes are expressed in many tissues that remain unaffected. Among the mechanisms that have been suggested for this enigmatic phenomenon is dosage-sensitiv
Externí odkaz:
https://doaj.org/article/62a3bb75a34645f88df47777f75d85ba
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007327 (2018)
A longstanding puzzle in human genetics is what limits the clinical manifestation of hundreds of hereditary diseases to certain tissues, while their causal genes are expressed throughout the human body. A general conception is that tissue-selective d
Externí odkaz:
https://doaj.org/article/399278641a8e4429a3ab40b7e98610e2