Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Esther van de Kerkhof"'
Autor:
Michael Beverly, Jeremy Baryza, Chandra Vargeese, Olivier Heudi, Thomas Faller, Jürg Hunziker, Julien A. Boos, Karine Litherland, Markus Stoeckli, Piet Swart, Keith Bowman, Francois Natt, Iwan Beuvink, Esther van de Kerkhof, Jesper Christensen, Joel Krauser
Publikováno v:
Drug Metabolism and Disposition. 42:431-440
Absorption, distribution, metabolism, and excretion properties of a small interfering RNA (siRNA) formulated in a lipid nanoparticle (LNP) vehicle were determined in male CD-1 mice following a single intravenous administration of LNP-formulated [(3)H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4d9490ba4aec0852d6e9059a6ec750
https://doi.org/10.1124/dmd.113.055434
https://doi.org/10.1124/dmd.113.055434
Autor:
Francois Natt, Thomas Faller, Joel Krauser, Esther van de Kerkhof, Juerg Hunziker, Karine Litherland, Jesper Christensen, Piet Swart
Publikováno v:
Drug Metabolism and Disposition. 41:1211-1219
Absorption, distribution, metabolism, and excretion properties of two unformulated model short interfering RNA (siRNAs) were determined using a single internal [(3)H]-radiolabeling procedure, in which the full-length oligonucleotides were radiolabele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f517889d1de3a0a0211682de90694ec
https://doi.org/10.1124/dmd.112.050666
https://doi.org/10.1124/dmd.112.050666
Autor:
Joel Krauser, Esther van de Kerkhof, Frédéric Lozac'h, Alexandre Catoire, Thomas Faller, Jesper Christensen, Piet Swart, Karine Litherland, Francois Natt, Jürg Hunziker, Maxime Garnier
Publikováno v:
Pharmacology Research & Perspectives
The chemical modification 2′‐O‐methyl of nucleosides is often used to increase siRNA stability towards nuclease activities. However, the metabolic fate of modified nucleosides remains unclear. Therefore, the aim of this study was to determine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b71cf5c11f6d9a383a30b18ac695f4a
https://doi.org/10.1002/prp2.209
https://doi.org/10.1002/prp2.209
Autor:
Michael Beverly, Armin Beyerbach, Karine Litherland, David Morrissey, Julien A. Boos, Mari-Luz Piccolotto, Piet Swart, Juerg Hunziker, Andre Dattler, Werner Zuercher, Thomas Faller, Sandro Gfeller, David W. Kirk, Iwan Beuvink, Fabian Von Arx, Esther van de Kerkhof, Jesper Christensen, Philippe Neuner, William Leonard Wishart
Publikováno v:
Nucleic Acids Research
Efficient tissue-specific delivery is a crucial factor in the successful development of therapeutic oligonucleotides. Screening for novel delivery methods with unique tissue-homing properties requires a rapid, sensitive, flexible and unbiased techniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fbeae90599d659168cb139bc7414fc
https://doi.org/10.1093/nar/gkt515
https://doi.org/10.1093/nar/gkt515