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of 7
pro vyhledávání: '"Esther Z. Frenk"'
Autor:
Yuki Matsumura, Katie M. Stiles, Jasmine Reid, Esther Z. Frenk, Samantha Cronin, Odelya E. Pagovich, Ronald G. Crystal
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 72-82 (2019)
Aldehyde dehydrogenase 2 (ALDH2) deficiency causes “Asian flush syndrome,” presenting as alcohol-induced facial flushing, tachycardia, nausea, and headaches. One of the most common hereditary enzyme deficiencies, it affects 35%–40% of East Asia
Externí odkaz:
https://doaj.org/article/5da7c1a7b8d048de9d3148f3829970aa
Publikováno v:
Human gene therapy. 33(3-4)
Intravenous (IV) administration of naturally occurring adeno-associated virus (AAV) vectors are liver tropic, with a significant proportion of the total vector dose mediating gene expression in liver hepatocytes. AAV capsids that are directed toward
Autor:
Odelya E. Pagovich, Katie M. Stiles, Jasmine Reid, Yuki Matsumura, Esther Z Frenk, Samantha Cronin, Ronald G. Crystal
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss, Pp 72-82 (2019)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Aldehyde dehydrogenase 2 (ALDH2) deficiency causes “Asian flush syndrome,” presenting as alcohol-induced facial flushing, tachycardia, nausea, and headaches. One of the most common hereditary enzyme deficiencies, it affects 35%–40% of East Asia
Autor:
Fiona M Hart, Ronald G. Crystal, Bishnu P. De, Esther Z Frenk, Katie M. Stiles, Yuki Matsumura, Meredith L Sosulski, Stephen M. Kaminsky
Publikováno v:
JCI Insight
Alpha 1-antitrypsin (AAT) deficiency, a hereditary disorder characterized by low serum levels of functional AAT, is associated with early development of panacinar emphysema. AAT inhibits serine proteases, including neutrophil elastase, protecting the
Autor:
Jonathan B. Rosenberg, Neil R. Hackett, Jason G. Mezey, Ronald G. Crystal, Bishnu P. De, Nicole Tignor, Kim D. Janda, Esther Z Frenk, Stefan Worgall, George F. Koob, Martin J. Hicks, Odelya E. Pagovich, Stephen M. Kaminsky, Sunmee Wee
Publikováno v:
Human Gene Therapy. 23:451-459
Cocaine addiction is a major problem affecting all societal and economic classes for which there is no effective therapy. We hypothesized an effective anti-cocaine vaccine could be developed by using an adeno-associated virus (AAV) gene transfer vect
Autor:
Bishnu P. De, Maria J. Chiuchiolo, Neil R. Hackett, Jonathan P. Dyke, Esther Z Frenk, Douglas Ballon, Martin J. Hicks, Eric Aronowitz, Ronald G. Crystal, Kosuke Funato, Dolan Sondhi, Lan Wang, Viviane Tabar, Stephen M. Kaminsky, David F. Havlicek
Publikováno v:
Cancer gene therapy
The median survival of glioblastoma multiforme (GBM) is approximately 1 year. Following surgical removal, systemic therapies are limited by the blood-brain barrier. To circumvent this, we developed a method to modify neurons with the genetic sequence
Autor:
Stephanie Rhee, Ronald G. Crystal, Salim Bougarn, Stefan Worgall, Esther Z Frenk, Lucy Quach, Stephen M. Kaminsky, Wenzhu Wu, Amal Robay, Maria J. Chiuchiolo
Publikováno v:
Molecular Therapy. 23:S22-S23
We have developed a platform technology against infectious agents that mediates both passive and active immunity, with rapid, passive protection through the genetic delivery of an anti-pathogen monoclonal antibody together with long term protective a