Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Esther Y. Chao"'
Autor:
Timothy M. Willson, William J. Zuercher, Robert T. Nolte, Lisa A. Orband-Miller, Jon L. Collins, Aaron B. Miller, Donald P. McDonnell, Esther Y. Chao, Liping Wang, Stephanie Gaillard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:821-824
The design and synthesis of 4-hydroxytamoxifen (4-OHT) derivatives are described. The binding affinities of these compounds toward the orphan estrogen-related receptor gamma and the classical estrogen receptor alpha demonstrate that analogs bearing h
Publikováno v:
Organic Letters. 4:323-326
A solid-phase synthesis of substituted benzopyranoisoxazoles is described. The six-step synthesis features a novel method of generating nitrile oxides on a polymer support followed by an intramolecular 1,3-dipolar cycloaddition with a tethered alkyne
Autor:
Esther Y. Chao, Eugene L. Stewart, Shawn P. Williams, Jason Nichols, Nino Campobasso, Derek J. Parks, Robert W. Wiethe, Andrew N. Billin, Ping Wang, Angela Smallwood, Justin A. Caravella, Timothy M. Willson, William J. Zuercher, Cristin M. Galardi, Bryan Goodwin, Bryan A. Laffitte, Michael A. Watson, Christopher K. Glass, Jon L. Collins, Serena Ghisletti, Kenneth H. Pearce, Marie A. Iannone
Publikováno v:
Journal of medicinal chemistry. 51(18)
A cocrystal structure of T1317 (3) bound to hLXRbeta was utilized in the design of a series of substituted N-phenyl tertiary amines. Profiling in binding and functional assays led to the identification of LXR modulator GSK9772 ( 20) as a high-affinit
Autor:
Kathleen K. Brown, Frank Lee, Barry G. Shearer, David E. Uehling, Walter L Faison, Kimberly K. Adkison, Esther Y. Chao, Conrad Cowan, David N. Deaton, Tula Milliken, Bryan W. Sherman
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(16)
The design, synthesis, and SAR of a novel series of heterobiaryl phenethanolamine beta3 adrenergic receptor agonists are described. The furan analogue 49 was shown to elicit a significant dose-dependent lowering of plasma glucose in a rodent model of
Autor:
William J. Zuercher, Matthew R. Redinbo, Jon L. Collins, Timothy M. Willson, Yu Xue, Esther Y. Chao
The human pregnane X receptor (PXR) recognizes a range of structurally and chemically distinct ligands and plays a key role in regulating the expression of protective gene products involved in the metabolism and excretion of potentially harmful compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987506b2021a5445afd7a7c12d240542
Autor:
David N. Deaton, Kim K. Adkison, Tula Milliken, Kelly Horne Donaldson, Walter L Faison, Robert Hart, David E. Uehling, Neal F. Cariello, Kathleen K. Brown, Mark A. Paulik, Mary E. Lancaster, Esther Y. Chao, Bryan W. Sherman, Conrad Cowan, Jasmine Lin, Elizabeth E. Sugg, Barry G. Shearer
Publikováno v:
Journal of medicinal chemistry. 49(9)
The synthesis of a series of phenethanolamine aniline agonists that contain an aniline ring on the right-hand side of the molecule substituted at the meta position with a benzoic acid or a pyridyl carboxylate is described. Several of the analogues (e
Autor:
Lisa A. Orband-Miller, Jon L. Collins, Donald P. McDonnell, Timothy M. Willson, Esther Y. Chao, Liping Wang, Robert T. Nolte, Stephanie Gaillard, Aaron B. Miller, William J. Zuercher
Publikováno v:
ChemInform. 37
Autor:
Timothy M. Willson, Lisa A. Orband-Miller, Jon L. Collins, Barry G. Shearer, Stephanie Gaillard, David G Jones, William J. Zuercher, Esther Y. Chao, Aaron B. Miller, Donald P. McDonnell
Publikováno v:
Journal of medicinal chemistry. 48(9)
The first small molecule agonists of the estrogen-related receptors have been identified. GSK4716 (3) and GSK9089 (4) show binding to ERRgamma with remarkable selectivity over the classical estrogen receptors. Notably, in cell-based reporter assays,
Autor:
Millard H. Lambert, H. Eric Xu, Timothy M. Willson, Valerie G. Montana, Esther Y. Chao, Adam M. Fivush, Patrick R. Maloney, Curt D. Haffner, Marcos Luis Sznaidman, Christelle LeGrumelec, Michael Lawrence Sierra, William R. Oliver, Donna M. Goreham, Daniel D. Sternbach
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(9)
We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor delta (PPARdelta). Several hits were identified from our original libraries containing lipophilic carbo
Autor:
Victoria S. Latter, Esther Y. Chao, Naomi K. Cohn, Thomas A. Krenitsky, George W. Koszalka, Gertrude B. Elion, Janet L. Rideout, Raymond B. Williams
Publikováno v:
Journal of Medicinal Chemistry. 25:1040-1044
A series of 4-(alkylamino)-1-beta-D-ribofuranosyl-1H-pyrazolo[3, 4-d]pyrimidines was synthesized by enzymatic and chemical methods. On the basis of the previous finding that 4-(alkylthio)-1-beta-D-ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidines were effe