Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Esther W. Lim"'
Autor:
Martina Wallace, Le You, Jivani M. Gengatharan, Alan Saghatelian, Antonio Pinto, Christian M. Metallo, Matthew J. Kolar, Michal K. Handzlik, Esther W. Lim, Thekla Cordes, Mehmet G. Badur, Thangaselvam Muthusamy
Publikováno v:
Nature
Nature, vol 586, iss 7831
Nature, vol 586, iss 7831
Serine, glycine and other nonessential amino acids are critical for tumour progression, and strategies to limit their availability are emerging as potential therapies for cancer1-3. However, the molecular mechanisms driving this response remain uncle
Autor:
Jiejun Shi, Wei Li, Guang Lei, Bingliang Fang, Pranavi Koppula, Xiaoshan Zhang, Li Zhuang, Yilei Zhang, Xiaoguang Liu, Hyemin Lee, Christian M. Metallo, Masha V. Poyurovsky, M. James You, Boyi Gan, Esther W. Lim, Jie Zhang, Kellen L. Olszewski
Publikováno v:
Nature cell biology
SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival. Here we show that this comes at a significant cost for cancer cells with high levels of SLC7A11. Actively importing cystine is potentially toxic due to its l
Autor:
Reuben J. Shaw, Carlos M. Pondevida, Elijah Trefts, Jivani M. Gengatharan, Michal K. Handzlik, Esther W. Lim, Christian M. Metallo
Publikováno v:
Science Advances
Description
Alanine accumulation in PolgD257A mice links mitochondrial defects to 1-deoxysphingolipids and peripheral neuropathy.
Mitochondria are central to metabolic homeostasis, and progressive mitochondrial defects have diverse metaboli
Alanine accumulation in PolgD257A mice links mitochondrial defects to 1-deoxysphingolipids and peripheral neuropathy.
Mitochondria are central to metabolic homeostasis, and progressive mitochondrial defects have diverse metaboli
Publikováno v:
The FASEB Journal. 35
Autor:
Reuben J. Shaw, Elijah Trefts, Jivani M. Gengatharan, Michal K. Handzlik, Esther W. Lim, Christian M. Metallo
SummaryA decline in mitochondrial function is associated with neurodegeneration and aging. Progressive mitochondrial defects have diverse metabolic consequences that could drive some of the pathophysiological changes that occur with aging. Here, we c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebd040d5681b60ba84623a8b9bdc2698
https://doi.org/10.1101/2021.04.29.441996
https://doi.org/10.1101/2021.04.29.441996
Autor:
Isaac Perea-Gil, Timon Seeger, Arne A N Bruyneel, Vittavat Termglinchan, Emma Monte, Esther W Lim, Nirmal Vadgama, Takaaki Furihata, Alexandra A Gavidia, Jennifer Arthur Ataam, Nike Bharucha, Noel Martinez-Amador, Mohamed Ameen, Pooja Nair, Ricardo Serrano, Balpreet Kaur, Dries A M Feyen, Sebastian Diecke, Michael P Snyder, Christian M Metallo, Mark Mercola, Ioannis Karakikes
Publikováno v:
European heart journal. 43(36)
Aims Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite significant progress in understanding the genetic aetiologies of DCM, the molecular mechanisms underlying the pathogenesis of familial DCM remain unknown, translat
Autor:
Esther W. Lim, Kevin Eade, Michael I. Dorrell, Rebecca B. Berlow, Rando Allikmets, Sarah Giles, Regis Fallon, Joseph A. Hostyk, Sarah Harkins-Perry, Michelle Baldini, Martina Wallace, Lea Scheppke, Marin L. Gantner, Christian M. Metallo, Martin Friedlander, Carolyn Cai, Evan H. Baugh, David Goldstein, Charles J. Wolock, Takayuki Nagasaki
Publikováno v:
Nat Metab
Macular telangiectasia type 2 (MacTel) is a progressive, late-onset retinal degenerative disease linked to decreased serum levels of serine that elevate circulating levels of a toxic ceramide species, deoxysphingolipids (deoxySLs); however, causal ge
Deuterium Tracing to Interrogate Compartment-Specific NAD(P)H Metabolism in Cultured Mammalian Cells
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2088
Oxidation-reduction (redox) reactions are ubiquitous in biology and typically occur in specific subcellular compartments. In cells, the electron transfer between molecules and organelles is commonly facilitated by pyridine nucleotides such as nicotin
Deuterium Tracing to Interrogate Compartment-Specific NAD(P)H Metabolism in Cultured Mammalian Cells
Publikováno v:
Methods in Molecular Biology ISBN: 9781071601587
Oxidation-reduction (redox) reactions are ubiquitous in biology and typically occur in specific subcellular compartments. In cells, the electron transfer between molecules and organelles is commonly facilitated by pyridine nucleotides such as nicotin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fa11a310445bf0c771ba7b210c83c40
https://doi.org/10.1007/978-1-0716-0159-4_4
https://doi.org/10.1007/978-1-0716-0159-4_4
Autor:
Anna E. Thalacker-Mercer, Erica Bender, Jamie E. Blum, Mary E Gheller, Michal K. Handzlik, Esther W. Lim, Martha S. Field, Patrick J. Stover, Benjamin D. Cosgrove, Christian M. Metallo, Brandon J Gheller
SummarySkeletal muscle regeneration is reliant on a population of muscle specific adult stem cells (muscle progenitor cells; MPCs). During regeneration, the MPC population undergoes a transient and rapid period of population expansion, which is neces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18f44f49344a4d3c513820878d2d3f1
https://doi.org/10.1101/833798
https://doi.org/10.1101/833798