Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Esther W. Barrow"'
Autor:
Nagendra Prasad Muddala, Baskar Nammalwar, Subhashini Selvaraju, Christina R. Bourne, Mary Henry, Richard A. Bunce, K. Darrell Berlin, Esther W. Barrow, William W. Barrow
Publikováno v:
Molecules, Vol 20, Iss 4, Pp 7222-7244 (2015)
The synthesis and evaluation of ten new dihydrophthalazine-appended 2,4-diaminopyrimidines as potential drugs to treat Bacillus anthracis is reported. An improved synthesis utilizing a new pincer catalyst, dichlorobis[1-(dicyclohexylphosphanyl)-piper
Externí odkaz:
https://doaj.org/article/03e2156e05f748f3bffb83f13d3d41f3
Autor:
Baskar Nammalwar, N. Prasad Muddala, Christina R. Bourne, Mary Henry, Philip C. Bourne, Richard A. Bunce, Esther W. Barrow, K. Darrell Berlin, William W. Barrow
Publikováno v:
Molecules, Vol 19, Iss 3, Pp 3231-3246 (2014)
Due to the innate ability of bacteria to develop resistance to available antibiotics, there is a critical need to develop new agents to treat more resilient strains. As a continuation of our research in this area, we have synthesized a series of race
Externí odkaz:
https://doaj.org/article/9d94526dc14345a597e35fe0c5484090
Autor:
William W. Barrow, Baskar Nammalwar, Nagendra Prasad Muddala, Richard A. Bunce, Subhashini Selvaraju, Mary Henry, Christina R. Bourne, Esther W. Barrow, Kenneth Berlin
Publikováno v:
Molecules, Vol 20, Iss 4, Pp 7222-7244 (2015)
Molecules
Volume 20
Issue 4
Pages 7222-7244
Molecules (Basel, Switzerland)
Molecules
Volume 20
Issue 4
Pages 7222-7244
Molecules (Basel, Switzerland)
The synthesis and evaluation of ten new dihydrophthalazine-appended 2,4-diaminopyrimidines as potential drugs to treat Bacillus anthracis is reported. An improved synthesis utilizing a new pincer catalyst, dichlorobis[1-(dicyclohexylphosphanyl)-piper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dafbb1a07bfb4be46cc82d5d4f18746
http://www.mdpi.com/1420-3049/20/4/7222
http://www.mdpi.com/1420-3049/20/4/7222
Autor:
Richard A. Bunce, William W. Barrow, Christina R. Bourne, Esther W. Barrow, K. Darrell Berlin, Baskar Nammalwar, Nancy Wakeham, Philip C. Bourne, N. Prasad Muddala
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:203-211
The current Letter describes the synthesis and biological evaluation of dihydrophthalazine-appended 2,4-diaminopyrimidine (DAP) inhibitors (1) oxidized at the methylene bridge linking the DAP ring to the central aromatic ring and (2) modified at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19aced645063058597583e67dfe40026
https://doi.org/10.1016/j.bmc.2014.11.009
https://doi.org/10.1016/j.bmc.2014.11.009
Autor:
K. Darrell Berlin, Richard A. Bunce, Baskar Nammalwar, William W. Barrow, Shankari Mylvaganam, Philip C. Bourne, Christina R. Bourne, Esther W. Barrow, Nancy Wakeham, Kal Ramnarayan
Publikováno v:
ChemMedChem. 7:1974-1982
A series of (±)-6-alkyl-2,4-diaminopyrimidine-based inhibitors of bacterial dihydrofolate reductase (DHFR) have been prepared and evaluated for biological potency against Bacillus anthracis and Staphylococcus aureus. Biological studies reveal attenu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f81fbb16ff5a056bd7eb4a97886538
https://doi.org/10.1002/cmdc.201200291
https://doi.org/10.1002/cmdc.201200291
Autor:
Rebecca A. Duncan-Decocq, Patricia A. Clinkenbeard, Kimberly D. Hill, Nicole L. Clarkson, William W. Barrow, Michelle Wright Valderas, Kenneth D. Clinkenbeard, Christina R. Bourne, Esther W. Barrow, Rachel F. Perteet, Philip C. Bourne
Publikováno v:
SLAS Discovery. 17:946-956
One of the objectives of the National Institutes of Allergy and Infectious Diseases (NIAID) Biodefense Program is to identify or develop broad-spectrum antimicrobials for use against bioterrorism pathogens and emerging infectious agents. As a part of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70d3da963dd9b527159d2992301037c
https://doi.org/10.1177/1087057112448216
https://doi.org/10.1177/1087057112448216
Autor:
Baskar Nammalwar, Richard A. Bunce, K. Darrell Berlin, Christina R. Bourne, Esther W. Barrow, William W. Barrow, Philip C. Bourne
Publikováno v:
European Journal of Medicinal Chemistry. 54:387-396
A series of substituted 2,4-diaminopyrimidines 1 has been prepared and evaluated for activity against Bacillus anthracis using previously reported (±)-3-{5-[(2,4-diamino-5-pyrimidinyl)methyl]-2,3-dimethoxyphenyl}-1-(1-propyl-2(1 H )-phthalazinyl)-2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2577cea3a9b5ccdc8de4ee018cc0a6b0
https://doi.org/10.1016/j.ejmech.2012.05.018
https://doi.org/10.1016/j.ejmech.2012.05.018
Autor:
Richard A. Bunce, William W. Barrow, Baskar Nammalwar, Philip C. Bourne, Christina R. Bourne, Esther W. Barrow, K. Darrell Berlin
Publikováno v:
Organic Preparations and Procedures International. 44:281-287
Microwave-assisted organic synthesis is an area of increasing interest for promoting clean, reproducible, high-yielding reactions under mild conditions.1,2 This is evident from the large number of papers and reviews that have appeared on this topic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1d5a990848bd6f70e32d7b1b93a6d9
https://doi.org/10.1080/00304948.2012.676823
https://doi.org/10.1080/00304948.2012.676823
Autor:
Kenneth Berlin, Christina R. Bourne, William W. Barrow, Esther W. Barrow, Philip C. Bourne, Richard A. Bunce
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:3825-3833
The bacterial burden on human health is quickly outweighing available therapeutics. Our long-term goal is the development of antimicrobials with the potential for broad-spectrum activity. We previously reported phthalazine-based inhibitors of dihydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b622304196909b7b2f7371fdabc730c1
https://doi.org/10.1128/aac.00361-10
https://doi.org/10.1128/aac.00361-10
Publikováno v:
Medicinal Chemistry. 2:505-510
The present study extends our previous work regarding new antifolates for Mycobacterium avium (MAC) dihydrofolate reductase (DHFR). The objectives of this study were to synthesize and test new derivatives in the general class of 2,4-diamino-5-methyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e64a0905af99224b6c9b38138238314
https://doi.org/10.2174/157340606778250225
https://doi.org/10.2174/157340606778250225