Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Esther Sutter"'
Autor:
Kea Martin, Ursula Junker, Elaine Tritto, Esther Sutter, Tina Rubic-Schneider, Hannah Morgan, Satoru Niwa, Jianping Li, Achim Schlapbach, Dana Walker, Marc Bigaud, Christian Beerli, Amanda Littlewood-Evans, Bettina Rudolph, Marc Laisney, David Ledieu, Karen Beltz, Jean Quancard, Frédéric Bornancin, Natasa Zamurovic Ribrioux, Thomas Calzascia
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Genetic disruption or short-term pharmacological inhibition of MALT1 protease is effective in several preclinical models of autoimmunity and B cell malignancies. Despite these protective effects, the severe reduction in regulatory T cells (Tregs) and
Externí odkaz:
https://doaj.org/article/92eee817000748258e9659af159c4926
Autor:
Muriel Bellot, C. Marc Luetjens, Morten Bagger, Courtney Horvath, Esther Sutter, Anthony DeLise, Dominique Brees, José M. Carballido, Ratnakar Pingili, Krishnan Ramanathan, Bernd C. Kieseier, Kerstin Hellwig
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 108
Knowledge of the impacts of the anti-CD20 monoclonal antibody ofatumumab on the developing immune system is limited. This study examined the effects of intravenous ofatumumab on pregnancy, parturition, and lactation, and on pre- and postnatal surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a189381fa70939c38c8505d9df9734
https://pubmed.ncbi.nlm.nih.gov/34942355
https://pubmed.ncbi.nlm.nih.gov/34942355
Autor:
Arno Doelemeyer, Thierry Flandre, Vincent Romanet, Alessandro Piaia, Julie Boisclair, Esther Sutter, Kuno Wuersch, Gianluca Santarossa, Holger Hoefling, Tobias Sing, Chandrassegar Saravanan, Pierre Moulin, Oliver C. Turner, Imtiaz Hossain
Publikováno v:
Toxicologic pathology. 49(4)
We introduce HistoNet, a deep neural network trained on normal tissue. On 1690 slides with rat tissue samples from 6 preclinical toxicology studies, tissue regions were outlined and annotated by pathologists into 46 different tissue classes. From the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81fa38fd4827f974e39e9918e1611c20
https://pubmed.ncbi.nlm.nih.gov/33653171
https://pubmed.ncbi.nlm.nih.gov/33653171
Autor:
Esther Sutter, Henning Richter, Philippe Bijlenga, Katja Nuss, Graziano Pelli, Sandrine Morel, Vincent Braunersreuther, Brenda R. Kwak, Vanessa Graf, Juhana Frösen, Agnieszka Karol
Publikováno v:
Journal of Neurosurgery (2019) pp. 1-14
OBJECTIVEIntracranial aneurysms (IAs) are more often diagnosed in women. Hormones and vessel geometry, which influences wall shear stress, may affect pathophysiological processes of the arterial wall. Here, the authors investigated sex-related differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14fca82fe9593f32a411a7e059ae8de
https://doi.org/10.5167/uzh-186363
https://doi.org/10.5167/uzh-186363
Autor:
Karl Lothard Schaller, Marie-Luce Bochaton-Piallat, Esther Sutter, Renato Gondar, Philippe Bijlenga, Vincent Braunersreuther, Marco Vincenzo Corniola, Nicolas Dupuy, Mannekomba Roxane Diagbouga, Max Jägersberg, Brenda R. Kwak, Sandrine Morel, Graziano Pelli, Nathalie Isidor
Publikováno v:
Journal of Neuropathology and Experimental Neurology, Vol. 77, No 7 (2018) pp. 555-566
Pathogenesis of intracranial aneurysm is complex and the precise biomechanical processes leading to their rupture are uncertain. The goal of our study was to characterize the aneurysmal wall histologically and to correlate histological characteristic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a8a51cba081943bc9583e346edb224
https://doi.org/10.1093/jnen/nly031
https://doi.org/10.1093/jnen/nly031
Autor:
Tobias Sing, Arno Doelemeyer, Julie Boisclair, Santarossa G, Oliver C. Turner, Chandrassegar Saravanan, Esther Sutter, Imtiaz Hossain, Pierre Moulin, Alessandro Piaia, Holger Hoefling, Kuno Wuersch, Romanet, Thierry Flandre
Deep learning models have been applied on various tissues in order to recognize malignancies. However, these models focus on relatively narrow tissue context or well-defined pathologies. Here, instead of focusing on pathologies, we introduce models c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6cf3ee42cf4cb91979fcee0584ab45
Autor:
Diann Blanset, Maggie Dempster, Renaud Fleurance, Esther Sutter, Michael W. Leach, Timothy K. MacLachlan, Elizabeth Galbreath, Kathleen M. Heinz-Taheny, Laura Andrews, Anna Maria Giusti, Mary Ellen Cosenza, Joy A. Cavagnaro, Shari A. Price
Publikováno v:
Regulatory Toxicology and Pharmacology. 121:104872
Monoclonal antibodies (mAbs) and mAb derivatives have become mainstay pharmaceutical modalites. A critical assessment is to ascertain the specificity of these molecules prior to human clinical trials. The primary technique for determining specificity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad0a2670e20ca1eb2780cf9b882a8b8
https://doi.org/10.1016/j.yrtph.2021.104872
https://doi.org/10.1016/j.yrtph.2021.104872
Autor:
Yinuo Pang, Gaetane Woerly, Esther Sutter, Francois Pognan, Ursula Schramm, Yoav E Timsit, Marie Anne Valentin, Philippe Couttet, Armin Wolf, Beate Vogel, Ivan Demin, Birgit Jaitner, Ronenn Roubenoff
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 369(3)
The colony-stimulating factor-1 (CSF-1) receptor pathway has been implicated in a variety of diseases, and CSF-1-dependent mechanisms are also involved in bloodborne protein clearance. Lacnotuzumab is a novel, high-affinity, humanized, anti-CSF-1 mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef69e48a10a90d3ac1e1ed0857b5eac9
https://pubmed.ncbi.nlm.nih.gov/30894455
https://pubmed.ncbi.nlm.nih.gov/30894455
Autor:
David Ledieu, Anna Schubart, Francois Pognan, Esther Sutter, Jens Schümann, Pierre Moulin, Armelle Grevot, Serge Côté, Alessandro Piaia, Andreas Billich, Ursula Junker Walker, Christian Beerli, Armin Wolf
Publikováno v:
Toxicologic Pathology. 43:694-703
Sphingosine-1-phosphate (S1P) lyase is considered as a drug target in autoimmune diseases based on the protective effect of reducing activity of the enzyme in animal models of inflammation. Since S1P lyase deficiency in mice causes a severe, lethal p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ad407c706c0d6eb87c1b7fe0449a9d
https://doi.org/10.1177/0192623314565650
https://doi.org/10.1177/0192623314565650
Autor:
Vincent Romanet, Marion Wiesmann, Roland Rad, Eric Durand, William R. Sellers, Audrey Kauffmann, Sébastien Jeay, Francesco Hofmann, Armelle Grevot, Agnieszka Gembarska, Antoine de Weck, Emeline Mandon, Ralph Tiedt, Louise Barys, Esther Sutter, Michael Rugaard Jensen, Stephane Ferretti, Masato Murakami, Pierre Moulin, Joseph Lehar, Emilie A. Chapeau, Claire Estadieu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(12)
Inhibitors of double minute 2 protein (MDM2)-tumor protein 53 (TP53) interaction are predicted to be effective in tumors in which the TP53 gene is wild type, by preventing TP53 protein degradation. One such setting is represented by the frequent CDKN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f715a94c2eeaef47a25af6b4c43f33eb
https://pubmed.ncbi.nlm.nih.gov/28265066
https://pubmed.ncbi.nlm.nih.gov/28265066