Accelerated long-term forgetting in healthy older adults predicts cognitive decline over 1 year

Autor: Alfie R. Wearn, Esther Saunders-Jennings, Volkan Nurdal, Emma Hadley, Michael J. Knight, Margaret Newson, Risto A. Kauppinen, Elizabeth J. Coulthard

Publikováno v: Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-9 (2020)

Abstract Background Here, we address a pivotal factor in Alzheimer’s prevention—identifying those at risk early, when dementia can still be avoided. Recent research highlights an accelerated forgetting phenotype as a risk factor for Alzheimer’s

Externí odkaz: https://doaj.org/article/c0629d0866cd4c52b30c8136d4922930

T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment

Autor: Alfie R. Wearn, Volkan Nurdal, Esther Saunders-Jennings, Michael J. Knight, Christopher R. Madan, Sean-James Fallon, Hanna K. Isotalus, Risto A. Kauppinen, Elizabeth J. Coulthard

Publikováno v: NeuroImage, Vol 238, Iss , Pp 118214- (2021)

A better understanding of early brain changes that precede loss of independence in diseases like Alzheimer's disease (AD) is critical for development of disease-modifying therapies. Quantitative MRI, such as T2 relaxometry, can identify microstructur

Externí odkaz: https://doaj.org/article/a5bdcccec8ff4f3e826402421b5b6e00

T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment

Autor: Hanna K. Isotalus, Christopher R. Madan, Volkan Nurdal, Alfie Wearn, Risto A. Kauppinen, Elizabeth Coulthard, Esther Saunders-Jennings, Sean-James Fallon, Michael J. Knight

Publikováno v: Wearn, A R, Nurdal, V, Saunders-Jennings, E, Knight, M J, Madan, C R, Fallon, S-J, Isotalus, H K, Kauppinen, R A & Coulthard, E J 2021, ' T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment ', NeuroImage, vol. 238, 118214 . https://doi.org/10.1016/j.neuroimage.2021.118214
Neuroimage
NeuroImage, Vol 238, Iss, Pp 118214-(2021)

A better understanding of early brain changes that precede loss of independence in diseases like Alzheimer's disease (AD) is critical for development of disease-modifying therapies. Quantitative MRI, such as T2 relaxometry, can identify microstructur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c95e8c0e9239092665c17e0e090842
https://hdl.handle.net/1983/a3ee033e-f026-46ae-8026-2dbddb3f1bb2

T2 heterogeneity: a novel marker of microstructural integrity associated with cognitive decline in people with mild cognitive impairment

Autor: Risto A. Kauppinen, Michael J. Knight, Alfie Wearn, Esther Saunders-Jennings, Demitra Tsivos, Volkan Nurdal, Elizabeth Coulthard, Hanna K. Isotalus, Serena Dillon

Publikováno v: Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2020)
Wearn, A R, Nurdal, V, Saunders-Jennings, E, Knight, M J, Isotalus, H K, Dillon, S, Tsivos, D, Kauppinen, R A & Coulthard, E J 2020, ' T2 heterogeneity : a novel marker of microstructural integrity associated with cognitive decline in people with mild cognitive impairment ', Alzheimer's Research and Therapy, vol. 12, 105 (2020) . https://doi.org/10.1186/s13195-020-00672-9

Background Early Alzheimer’s disease (AD) diagnosis is vital for development of disease-modifying therapies. Prior to significant brain tissue atrophy, several microstructural changes take place as a result of Alzheimer’s pathology. These include

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08964a5b938171e8177775f66937611
https://pubmed.ncbi.nlm.nih.gov/32912337