Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Esther Roselló-LLetí"'
Autor:
Lorena Pérez-Carrillo, Isaac Giménez-Escamilla, Irene González-Torrent, Marta Delgado-Arija, Ignacio Sánchez-Lázaro, María García-Manzanares, Luis Martínez-Dolz, Manuel Portolés, Estefanía Tarazón, Esther Roselló-Lletí
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-5 (2024)
Abstract Long non-coding RNAs (lncRNAs) are closely implicated in biological processes and diseases with high inflammatory components. These molecules exhibit significant temporal and tissue specificity. However, the expression and function of lncRNA
Externí odkaz:
https://doaj.org/article/cd9317c670b14bbaafd5fbfba7ebb52b
Autor:
Marta Delgado-Arija, Patricia Genovés, Lorena Pérez-Carrillo, Irene González-Torrent, Isaac Giménez-Escamilla, Luis Martínez-Dolz, Manuel Portolés, Estefanía Tarazón, Esther Roselló-Lletí
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Cardiac fibroblast activation protein (FAP) has an emerging role in heart failure (HF). A paradoxical reduction in its levels in pathological conditions associated with acute processes has been observed. We aimed to identify FAP c
Externí odkaz:
https://doaj.org/article/7f007be5ed3a4a35954fc3151842bf82
Autor:
Isaac Giménez-Escamilla, Lorena Pérez-Carrillo, Irene González-Torrent, Marta Delgado-Arija, Carlota Benedicto, Manuel Portolés, Estefanía Tarazón, Esther Roselló-Lletí
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9590 (2024)
Heart failure (HF) is associated with global changes in gene expression. Alternative mRNA splicing (AS) is a key regulatory mechanism underlying these changes. However, the whole status of molecules involved in the splicing process in human HF is unk
Externí odkaz:
https://doaj.org/article/3dbf8751b6c849f6ad19e566e9e6a09c
Autor:
Alana Aragón-Herrera, Marinela Couselo-Seijas, Sandra Feijóo-Bandín, Laura Anido-Varela, Sandra Moraña-Fernández, Estefanía Tarazón, Esther Roselló-Lletí, Manuel Portolés, José Luis Martínez-Sande, Javier García-Seara, Ezequiel Álvarez, José Ramón González-Juanatey, Moisés Rodríguez-Mañero, Sonia Eiras, Francisca Lago
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Relaxin-2 exerts many favourable cardiovascular effects in pathological circumstances such as atrial fibrillation (AF) and heart failure, but the mechanisms underlying its actions are not completely understood. Since inflammation and fibrosi
Externí odkaz:
https://doaj.org/article/26b7187489d244cd8003e835c103ccd1
Autor:
Isaac Giménez-Escamilla, Carlota Benedicto, Lorena Pérez-Carrillo, Marta Delgado-Arija, Irene González-Torrent, Roger Vilchez, Luis Martínez-Dolz, Manuel Portolés, Estefanía Tarazón, Esther Roselló-Lletí
Publikováno v:
Antioxidants, Vol 13, Iss 3, p 285 (2024)
Heart failure (HF) is a disease related to bioenergetic mitochondrial abnormalities. However, the whole status of molecules involved in the oxidative phosphorylation system (OXPHOS) is unknown. Therefore, we analyzed the OXPHOS transcriptome of human
Externí odkaz:
https://doaj.org/article/4647f54cd85140c2a0e303b44a379907
Autor:
Alana Aragón-Herrera, Sandra Moraña-Fernández, Manuel Otero-Santiago, Laura Anido-Varela, Manuel Campos-Toimil, Javier García-Seara, Ana Román, José Seijas, Lucía García-Caballero, Javier Rodríguez, Estefanía Tarazón, Esther Roselló-Lletí, Manuel Portolés, Ricardo Lage, Oreste Gualillo, José Ramón González-Juanatey, Sandra Feijóo-Bandín, Francisca Lago
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 161, Iss , Pp 114535- (2023)
The pharmacological inhibition of sodium-glucose cotransporter 2 (SGLT2) has emerged as a treatment for patients with type 2 diabetes mellitus (T2DM), cardiovascular disease and/or other metabolic disturbances, although some of the mechanisms implica
Externí odkaz:
https://doaj.org/article/25810c314aa64857b4150a43206f7eb0
Autor:
Lorena Pérez-Carrillo, Isaac Giménez-Escamilla, María García-Manzanares, Juan Carlos Triviño, Sandra Feijóo-Bandín, Alana Aragón-Herrera, Francisca Lago, Luis Martínez-Dolz, Manuel Portolés, Estefanía Tarazón, Esther Roselló-Lletí
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1337 (2023)
Ischemic cardiomyopathy (ICM) is associated with abnormal microRNA expression levels that involve an altered gene expression profile. However, little is known about the underlying causes of microRNA disruption in ICM and whether microRNA maturation i
Externí odkaz:
https://doaj.org/article/5dc4d9e5dcee4e24984352897a18347d
Autor:
Alana Aragón-Herrera, Manuel Otero-Santiago, Laura Anido-Varela, Sandra Moraña-Fernández, Manuel Campos-Toimil, Tomás García-Caballero, Luis Barral, Estefanía Tarazón, Esther Roselló-Lletí, Manuel Portolés, Oreste Gualillo, Isabel Moscoso, Ricardo Lage, José Ramón González-Juanatey, Sandra Feijóo-Bandín, Francisca Lago
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcome Event Trial in patients with Type 2 Diabetes Mellitus (T2DM)) trial evidenced the potential of sodium-glucose cotransporter 2 (SGLT2) inhibitors for the treatment of patients with diabetes a
Externí odkaz:
https://doaj.org/article/0582b3904297450b8681e7c0da82b354
Autor:
Lorena Pérez-Carrillo, Alana Aragón-Herrera, Isaac Giménez-Escamilla, Marta Delgado-Arija, María García-Manzanares, Laura Anido-Varela, Francisca Lago, Luis Martínez-Dolz, Manuel Portolés, Estefanía Tarazón, Esther Roselló-Lletí
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 1996 (2022)
Despite the reduction of cardiovascular events, including the risk of death, associated with sodium/glucose cotransporter 2 inhibitors (SGLT2i), their basic action remains unclear. Sodium/hydrogen exchanger (NHE) has been proposed as the mechanism of
Externí odkaz:
https://doaj.org/article/c73748aac3504694b5fd24e2f692ac2a
Autor:
Estefanía Tarazón, Carolina Gil-Cayuela, María García Manzanares, Marta Roca, Francisca Lago, José Ramón González-Juanatey, Elena Sánchez-Lacuesta, Luis Martínez-Dolz, Manuel Portolés, Esther Roselló-Lletí
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Accumulating evidence has confirmed that the expression of sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) is downregulated in heart failure and cardiac allograft rejection. Although many SERCA2a-related genes and proteins involved in the
Externí odkaz:
https://doaj.org/article/ea18da563d0148cd86d919cef693e595