Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Esther Roitman"'
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 82:225-232
Patients with Smith-Lemli-Opitz syndrome have impaired ability to synthesize cholesterol due to attenuated activity of 7-dehydrosterol-delta(7)-reductase which catalyses the final step in cholesterol synthesis. Accumulation of 7- and 8-dehydrocholest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e59cae1ae5cf06ca84c878338b8570
https://doi.org/10.1016/s0960-0760(02)00155-3
https://doi.org/10.1016/s0960-0760(02)00155-3
Publikováno v:
Prenatal Diagnosis. 21:207-212
Gas chromatographic/mass spectrometric (GC/MS) analysis of maternal urine and serum steroids from 13 pregnancies at 25% risk for Smith-Lemli-Opitz syndrome (SLOS) was undertaken. All patients were between 12 and 31 weeks' gestational age From dehydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::880407618921d41325e3bdb897f267db
https://doi.org/10.1002/1097-0223(200103)21:3<207::aid-pd27>3.0.co
https://doi.org/10.1002/1097-0223(200103)21:3<207::aid-pd27>3.0.co
Autor:
Marilyn B. Renfree, Esther Roitman, Michael W. Leihy, Jean D. Wilson, Geoffrey Shaw, Cedric H.L. Shackleton
Publikováno v:
Proceedings of the National Academy of Sciences. 97:12256-12259
Development of the male urogenital tract in mammals is mediated by testicular androgens. It has been tacitly assumed that testosterone acts through its intracellular metabolite dihydrotestosterone (DHT) to mediate this process, but levels of these an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8db1118fd3eeeabf249a6be1844aff
https://doi.org/10.1073/pnas.220412297
https://doi.org/10.1073/pnas.220412297
Publikováno v:
Steroids. 64:446-452
Smith-Lemli-Opitz syndrome (SLOS) is a malformation syndrome associated with 7-dehydrocholesterol (7DHC) 7-reductase deficiency. Although SLOS can be detected in an affected fetus before midpregnancy by measurement of 7DHC levels in amniotic fluid or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5719c0d3c0e88ed990455f602cba131
https://doi.org/10.1016/s0039-128x(99)00026-4
https://doi.org/10.1016/s0039-128x(99)00026-4
Publikováno v:
Steroids. 64:481-490
The biosynthetic abnormality in Smith-Lemli-Opitz syndrome (SLOS) is a deficiency of 7-dehydrocholesterol (7DHC) reductase, the enzyme responsible for catalyzing the final step in the Kandutsch-Russell pathway for cholesterol synthesis. Because the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16c37cd4f97b612592796e2e4dababc
https://doi.org/10.1016/s0039-128x(99)00022-7
https://doi.org/10.1016/s0039-128x(99)00022-7
Autor:
Tony Chang, Larry J. Shapiro, Ian A. Glass, Russell C. Lam, Esther Roitman, Cedric H.L. Shackleton
Publikováno v:
Prenatal Diagnosis. 18:789-800
A method for determining whether a pregnant woman with an extremely low serum oestriol (ELSE) measurement of mid-trimester is carrying a fetus with steroid sulphatase deficiency or another more serious disorder is described. We undertook GC/MS analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::937192956f433dcd1f7aee65dd50717d
https://doi.org/10.1002/(sici)1097-0223(199808)18:8<789::aid-pd345>3.0.co
https://doi.org/10.1002/(sici)1097-0223(199808)18:8<789::aid-pd345>3.0.co
Autor:
Renee K. Emerson, Esther Roitman, Cedric H.L. Shackleton, Cynthia F. Bearer, Mary Ann O'Riordan
Publikováno v:
Environmental Health Perspectives
We propose that in utero exposure to tobacco smoke products places a newborn at risk for persistent pulmonary hypertension of the newborn (PPHN). To test this hypothesis, infants with PPHN were identified. Healthy newborns of similar ethnicity were i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fa6c645bbe712bbf3c95f99e17ff34
http://europepmc.org/articles/PMC1469798
http://europepmc.org/articles/PMC1469798
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 45:571-580
Treatment of 19-[oxygenated]-androst-4-ene-3,17-dione with Mn(AcO) 3 and ClCH 2 COOH in benzene gave epimeric mixtures of the corresponding 2ξ-chloroacetates and 2ξ-acetates. The products were processed to give the title compound. For the synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9518e99bc88bc7dcd1e87efe8c2fc9
https://doi.org/10.1016/0960-0760(93)90174-u
https://doi.org/10.1016/0960-0760(93)90174-u
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :1191-1195
Current evidence is consistent with the view that biosynthesis of estrogens by human microsomal placental aromatase proceeds through several different pathways. One of the proposed mechanisms of aromatization of androgens involves the intermediacy of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c8a8f4118b69a7c93f805052c5dca19
https://doi.org/10.1039/p19930001191
https://doi.org/10.1039/p19930001191
Autor:
Eliahu Caspi, Esther Roitman, H. Ranjith W. Dharmaratne, James. L. Kilgore, Cedric H. L. Shackleton
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :1529-1535
The 16- 2H 2 title compound 5b constituted a significant amount of the non-aromatic metabolites recovered from incubations of 3,17-dioxo-[16,16,19- 2H 3]androst-4-en-19-al 1 with placental aromatase. For the evaluation of the role of compound 5b in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a64844be2e68045d3114c6ea26552adf
https://doi.org/10.1039/p19930001529
https://doi.org/10.1039/p19930001529