Výsledky vyhledávání - "Esther Redin"

Akademický článek

G9a/DNMT1 co-targeting inhibits non-small cell lung cancer growth and reprograms tumor cells to respond to cancer-drugs through SCARA5 and AOX1

Publikováno v: Cell Death and Disease, Vol 15, Iss 11, Pp 1-16 (2024)

Abstract The treatment of non-small cell lung cancer (NSCLC) patients has significantly improved with recent therapeutic strategies; however, many patients still do not benefit from them. As a result, new treatment approaches are urgently needed. In

Externí odkaz: https://doaj.org/article/6e85bcef9c6c4041a19b62d5fdc24ce3

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Akademický článek

SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing

Autor: Esther Redin, Harsha Sridhar, Yingqian A. Zhan, Barbara Pereira Mello, Hong Zhong, Vidushi Durani, Amin Sabet, Parvathy Manoj, Irina Linkov, Juan Qiu, Richard P. Koche, Elisa de Stanchina, Maider Astorkia, Doron Betel, Álvaro Quintanal-Villalonga, Charles M. Rudin

Publikováno v: Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-19 (2024)

Abstract Introduction Small Cell Lung Cancer (SCLC) can be classified into transcriptional subtypes with distinct degrees of neuroendocrine (NE) differentiation. Recent evidence supports plasticity among subtypes with a bias toward adoption of low-NE

Externí odkaz: https://doaj.org/article/863d3755b2ea4eb2a85f6bb551cf6172

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Akademický článek

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation

Publikováno v: Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-14 (2024)

Abstract Neuroendocrine (NE) transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor prognosis. Up to date, even if patients at high risk of transformation can be identified by the occurren

Externí odkaz: https://doaj.org/article/501fe4c8a5e9423ca573e0d9f455d0b2

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Akademický článek

Innate and Adaptive Responses of Intratumoral Immunotherapy with Endosomal Toll-Like Receptor Agonists

Autor: Fernando Torres Andón, Sergio Leon, Aldo Ummarino, Esther Redin, Paola Allavena, Diego Serrano, Clément Anfray, Alfonso Calvo

Publikováno v: Biomedicines, Vol 10, Iss 7, p 1590 (2022)

Toll-like receptors (TLRs) are natural initial triggers of innate and adaptive immune responses. With the advent of cancer immunotherapy, nucleic acids engineered as ligands of endosomal TLRs have been investigated for the treatment of solid tumors.

Externí odkaz: https://doaj.org/article/1f97ef01232245cdb9d2e018eb99912a

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Akademický článek

SRC family kinase (SFK) inhibitor dasatinib improves the antitumor activity of anti-PD-1 in NSCLC models by inhibiting Treg cell conversion and proliferation

Autor: Jackeline Agorreta, Ana Remirez, Ruben Pio, Luis M Montuenga, Teresa Lozano, Esther Redin, Irati Garmendia, Diego Serrano, Yaiza Senent, Miriam Redrado, Maria Villalba, Francisco Exposito, Daniel Ajona, Sergio Ortiz-Espinosa, Cristina Bertolo, Cristina Sainz, Juana Garcia-Pedrero, Juan Lasarte, Alfonso Calvo

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)

Introduction The use of immune-checkpoint inhibitors has drastically improved the management of patients with non-small cell lung cancer (NSCLC), but innate and acquired resistances are hurdles needed to be solved. Immunomodulatory drugs that can rei

Externí odkaz: https://doaj.org/article/168f0e31c2614696a5307d18a104e8ba

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Abstract 6188: Exportin 1 inhibition synergizes with lurbinectedin by altering the response to DNA damage in neuroendocrine lung tumors

Autor: Esther Redin Resano, Charles Rudin, Alvaro Quintanal-Villalonga

Publikováno v: Cancer Research. 83:6188-6188

Background: Neuroendocrine lung cancer carcinomas (Lung NECs), which include large cell neuroendocrine carcinomas (LCNECs) and small cell lung cancer (SCLC) tumors, are particularly aggressive lung neoplasms with limited clinical therapeutic options.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::200606476319ded7fe1603e1fffee8e2
https://doi.org/10.1158/1538-7445.am2023-6188

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Inhibition of adjuvant-induced TAM receptors potentiates cancer vaccine immunogenicity and therapeutic efficacy

Autor: Alfonso Calvo, Jay A. Berzofsky, Pablo Sarobe, David F. Stroncek, Josune Egea, David Repáraz, Esther Redin, Belén Aparicio, Juan José Lasarte, Leyre Silva, Matthew Angel, Diana Llopiz, Marta Ruiz

Publikováno v: Cancer Lett

Analyzing immunomodulatory elements operating during antitumor vaccination in prostate cancer patients and murine models we identified IL-10-producing DC as a subset with poorer immunogenicity and clinical efficacy. Inhibitory TAM receptors MER and A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f4ac0bb08ded356129b4b9d130903f
https://doi.org/10.1016/j.canlet.2020.11.022

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YES1 Is a Druggable Oncogenic Target in SCLC

Autor: Esther Redin, Eva M. Garrido-Martin, Karmele Valencia, Miriam Redrado, Jose Luis Solorzano, Rafael Carias, Mirari Echepare, Francisco Exposito, Diego Serrano, Irene Ferrer, Angel Nunez-Buiza, Irati Garmendia, Juana M. García-Pedrero, Alfonso Gurpide, Luis Paz-Ares, Katerina Politi, Luis M. Montuenga, Alfonso Calvo

Publikováno v: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 17(12)

SCLC is an extremely aggressive subtype of lung cancer without approved targeted therapies. Here we identified YES1 as a novel targetable oncogene driving SCLC maintenance and metastasis.Association between YES1 levels and prognosis was evaluated in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11fc206de497c5d6f6b89031a50c4340
https://pubmed.ncbi.nlm.nih.gov/35988891

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