Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Esther P. Jane"'
Autor:
Esther P. Jane, Matthew C. Reslink, Taylor A. Gatesman, Matthew E. Halbert, Tracy A. Miller, Brian J. Golbourn, Stephanie M. Casillo, Steven J. Mullett, Stacy G. Wendell, Udochukwu Obodo, Dinesh Mohanakrishnan, Riya Dange, Antony Michealraj, Charles Brenner, Sameer Agnihotri, Daniel R. Premkumar, Ian F. Pollack
Publikováno v:
Molecular Oncology, Vol 17, Iss 9, Pp 1821-1843 (2023)
In previous studies, we demonstrated that panobinostat, a histone deacetylase inhibitor, and bortezomib, a proteasomal inhibitor, displayed synergistic therapeutic activity against pediatric and adult high‐grade gliomas. Despite the remarkable init
Externí odkaz:
https://doaj.org/article/855c1c665c7544d3830b200c1e512815
Autor:
Stephanie M. Casillo, Taylor A. Gatesman, Akanksha Chilukuri, Srinidhi Varadharajan, Brenden J. Johnson, Daniel R. David Premkumar, Esther P. Jane, Tritan J. Plute, Robert F. Koncar, Ann-Catherine J. Stanton, Carlos A.O. Biagi-Junior, Callie S. Barber, Matthew E. Halbert, Brian J. Golbourn, Katharine Halligan, Andrea F. Cruz, Neveen M. Mansi, Allison Cheney, Steven J. Mullett, Clinton Van’t Land, Jennifer L. Perez, Max I. Myers, Nishant Agrawal, Joshua J. Michel, Yue-Fang Chang, Olena M. Vaske, Antony MichaelRaj, Frank S. Lieberman, James Felker, Sruti Shiva, Kelsey C. Bertrand, Nduka Amankulor, Costas G. Hadjipanayis, Kalil G. Abdullah, Pascal O. Zinn, Robert M. Friedlander, Taylor J. Abel, Javad Nazarian, Sriram Venneti, Mariella G. Filbin, Stacy L. Gelhaus, Stephen C. Mack, Ian F. Pollack, Sameer Agnihotri
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113557- (2024)
Summary: Metabolic reprogramming in pediatric diffuse midline glioma is driven by gene expression changes induced by the hallmark histone mutation H3K27M, which results in aberrantly permissive activation of oncogenic signaling pathways. Previous stu
Externí odkaz:
https://doaj.org/article/a1cfb726d57743518bf0449e2947643f
Autor:
Esther P. Jane, Daniel R. Premkumar, Dhivyaa Rajasundaram, Swetha Thambireddy, Matthew C. Reslink, Sameer Agnihotri, Ian F. Pollack
Publikováno v:
Molecular Oncology, Vol 16, Iss 1, Pp 219-249 (2022)
Acquired resistance to conventional chemotherapeutic agents limits their effectiveness and can cause cancer treatment to fail. Because enzymes in the aurora kinase family are vital regulators of several mitotic events, we reasoned that targeting thes
Externí odkaz:
https://doaj.org/article/3cd2313c7d254eaab053411dfc37ad9e
Autor:
Ian F. Pollack, Andrew M. Stern, Mark E. Schurdak, D. Lansing Taylor, Ansuman Chattopadhyay, Max I. Myers, Stephen C. Mack, Kelsey C. Bertrand, Sameer Agnihotri, Brian Golbourn, Swetha Thambireddy, Daniel R. Premkumar, Esther P. Jane
Supplemental File 2: Genes common to all resistant U87 cell lines compared to drug naive control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f7077cb773aa084ad299586693d6ac
https://doi.org/10.1158/1541-7786.22514064
https://doi.org/10.1158/1541-7786.22514064
Autor:
Ian F. Pollack, Andrew M. Stern, Mark E. Schurdak, D. Lansing Taylor, Ansuman Chattopadhyay, Max I. Myers, Stephen C. Mack, Kelsey C. Bertrand, Sameer Agnihotri, Brian Golbourn, Swetha Thambireddy, Daniel R. Premkumar, Esther P. Jane
Supplemental File 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa56ff9776a3bec668f53c229ce01fd5
https://doi.org/10.1158/1541-7786.22514055
https://doi.org/10.1158/1541-7786.22514055
Autor:
Ian F. Pollack, Andrew M. Stern, Mark E. Schurdak, D. Lansing Taylor, Ansuman Chattopadhyay, Max I. Myers, Stephen C. Mack, Kelsey C. Bertrand, Sameer Agnihotri, Brian Golbourn, Swetha Thambireddy, Daniel R. Premkumar, Esther P. Jane
Supplemental Figure 4. Volcano plot representing differentially expressed genes for U87 naive versus resistant cells with a minimum of a 1.5-fold change, P-value < 0.05 and FDR < 0.10 between control and A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fc6e09dc92a9d4ceb7c99fb2ce7fac
https://doi.org/10.1158/1541-7786.22514082
https://doi.org/10.1158/1541-7786.22514082
Previous studies have shown that the tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) has significant apoptosis-inducing activity in some glioma cell lines, although many lines are either moderately or completely resistant, which has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9b12780be3b65abe1db363eb057a12b
https://doi.org/10.1158/1535-7163.c.6535389
https://doi.org/10.1158/1535-7163.c.6535389
Autor:
Ian F. Pollack, Andrew M. Stern, Mark E. Schurdak, D. Lansing Taylor, Ansuman Chattopadhyay, Max I. Myers, Stephen C. Mack, Kelsey C. Bertrand, Sameer Agnihotri, Brian Golbourn, Swetha Thambireddy, Daniel R. Premkumar, Esther P. Jane
Supplemental Figure 1. Schematic of the approach taken to achieve drug resistance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e28665fbf234b5a3b0cd1d5862b6aa
https://doi.org/10.1158/1541-7786.22514091.v1
https://doi.org/10.1158/1541-7786.22514091.v1
Autor:
Ian F. Pollack, Shi-Yuan Cheng, Bo Hu, Joseph D. DiDomenico, Daniel R. Premkumar, Esther P. Jane
PDF file - 69K, Effect of YM-155 and ABT-737 on human astrocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e58b0159ea954593122bb589f18180
https://doi.org/10.1158/1535-7163.22497721.v1
https://doi.org/10.1158/1535-7163.22497721.v1
Autor:
Ian F. Pollack, Andrew M. Stern, Mark E. Schurdak, D. Lansing Taylor, Ansuman Chattopadhyay, Max I. Myers, Stephen C. Mack, Kelsey C. Bertrand, Sameer Agnihotri, Brian Golbourn, Swetha Thambireddy, Daniel R. Premkumar, Esther P. Jane
Supplemental Figure 3. Drug naive U87 or panobinostat-resistant, bortezomib-resistant, or panobinostat and bortezomib-resistant (P + B) cells were cotreated with panobinostat (25 nmol/L) plus bortezomib (2.5 nmol/L) for 24 h.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779a7a10817c7974c156afe0f62f268a
https://doi.org/10.1158/1541-7786.22514085.v1
https://doi.org/10.1158/1541-7786.22514085.v1