Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver DiseaseSummary

Autor: Emmelie Cansby, Esther Nuñez-Durán, Elin Magnusson, Manoj Amrutkar, Sheri L. Booten, Nagaraj M. Kulkarni, L. Thomas Svensson, Jan Borén, Hanns-Ulrich Marschall, Mariam Aghajan, Margit Mahlapuu

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 597-618 (2019)

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide. Currently, no specific pharmacologic therapy is available for NAFLD/NASH, which has been re

Externí odkaz: https://doaj.org/article/9be6ef8a91c74cad8b389b66aebc0dd6

Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver

Autor: Annika, Nerstedt, Yeshwant, Kurhe, Emmelie, Cansby, Mara, Caputo, Lei, Gao, Egor, Vorontsov, Marcus, Ståhlman, Esther, Nuñez-Durán, Jan, Borén, Hanns-Ulrich, Marschall, Douglas G, Mashek, Darren N, Saunders, Carina, Sihlbom, Andrew J, Hoy, Margit, Mahlapuu

Publikováno v: J Lipid Res

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide and have been recognized as one of the major unmet medical needs of the 21st century. Our recent translational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3f055d0a1e4e28ef0d8e52d9a3315674
https://pubmed.ncbi.nlm.nih.gov/31857389

STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue

Autor: Silva Sütt, Brian W. Howell, Esther Nuñez-Durán, Jurga Laurencikiene, Sven Enerbäck, Jan Borén, Margit Mahlapuu, Manoj Amrutkar, Nagaraj M. Kulkarni, Alexandra Paul, Marcus Ståhlman, Emmelie Cansby

Whole-body energy homeostasis at over-nutrition critically depends on how well adipose tissue remodels in response to excess calories. We recently identified serine/threonine protein kinase (STK)25 as a critical regulator of ectopic lipid storage in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236089ae488cf371b37971685c446083
http://hdl.handle.net/10852/71658

Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle

Autor: Margit Mahlapuu, Maria E. Johansson, Jan Borén, Silva Sütt, Urszula Chursa, Emmelie Cansby, Carina Sihlbom, Manoj Amrutkar, Esther Nuñez-Durán, Bengt Johansson, Fredrik Bäckhed, Britt-Marie Olsson, Marcus Ståhlman

Publikováno v: Chursa, U, Nuñez-Durán, E, Cansby, E, Amrutkar, M, Sütt, S, Ståhlman, M, Olsson, B-M, Borén, J, Johansson, M E, Bäckhed, G F, Johansson, B R, Sihlbom, C & Mahlapuu, M 2017, ' Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle ', Diabetologia, vol. 60, no. 3, pp. 553-567 . https://doi.org/10.1007/s00125-016-4171-5
Diabetologia

Aims/hypothesis Understanding the molecular networks controlling ectopic lipid deposition and insulin responsiveness in skeletal muscle is essential for developing new strategies to treat type 2 diabetes. We recently identified serine/threonine prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e350f8fe787675410ccb10637c693c8d
https://curis.ku.dk/portal/da/publications/overexpression-of-protein-kinase-stk25-in-mice-exacerbates-ectopic-lipid-accumulation-mitochondrial-dysfunction-and-insulin-resistance-in-skeletal-muscle(10f50b19-be50-46e6-8657-bca85733686f).html

STK25 is a critical determinant in nonalcoholic steatohepatitis

Autor: Matthias Kern, Margit Mahlapuu, Marcus Ståhlman, Hanns-Ulrich Marschall, Esther Nuñez-Durán, Urszula Chursa, Manoj Amrutkar, Bengt Johansson, Matthias Blüher, Silva Sütt, Jan Borén

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30(10)

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and 10-20% of patients with NAFLD progress to nonalcoholic steatohepatitis (NASH) with a high risk of cirrhosis, liver failure, and hepatocellular carcinoma. Despite i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d12154a61e5d3eebc7b90ba5e7603d
https://pubmed.ncbi.nlm.nih.gov/27421788