Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Esther Martinborough"'
Autor:
Esther Martinborough, Donald S. Karanewsky, Francisco J. López, Robert I. Higuchi, Min Wu, William Y. Chang, Marquis L. Cummings, Lin Zhi, Thomas Lau, Yun Oliver Long, Thomas R. Caferro, Keith B. Marschke
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2967-2971
Modification on a lead series of [1,4]oxazino[3,2-g]quinolin-7-ones at the 2-position led to selective androgen receptor modulators with improved in vivo activity. The most potent analog (-)-33a exhibited full maintenance of levator ani muscle at 3mg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552333f5b43ce9586e4d20f15f4bb123
https://doi.org/10.1016/j.bmcl.2008.03.062
https://doi.org/10.1016/j.bmcl.2008.03.062
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :747-762
A series of optically active 1,1′-binaphthalene-derived receptors with N-(pyridine-2,6-diyl)acetamide [CONH(py)] H-bonding sites in the 6,6′-positions has been prepared for the enantioselective complexation of the N-carbobenzyloxy (Cbz)-protected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a1208f4f756dcb58a7d8865baa2dc91
https://doi.org/10.1039/a800233i
https://doi.org/10.1039/a800233i
Autor:
Tiziana Z. Mordasini Denti, Tara B. Wyman, Esther Martinborough, Carolyn B. Knobler, Peter P. Castro, François Diederich
Publikováno v:
Helvetica Chimica Acta. 78:1037-1066
The complexation of N-benzyloxycarbonyl (Cbz) derivatives of the excitatory amino acids L-aspartic acid (Asp; 1), L-glutamic acid (Glu; 3), and, for the first time, L-kainic acid ((2S,3S,3S)-2-carboxy-4-(1-methylethenyl)pyrrolidine-3-acetic acid; Kai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::055f2c27bb70691749e19eaf3e467522
https://doi.org/10.1002/hlca.19950780502
https://doi.org/10.1002/hlca.19950780502
Chiral Recognition of Cinchona Alkaloids at the Minor and Major Grooves of 1,1'-Binaphthyl Receptors
Autor:
Carolyn B. Knobler, Jon Reeder, Esther Martinborough, Linda Owens, François Diederich, Peter P. Castro
Publikováno v:
The Journal of Organic Chemistry. 59:3151-3160
A variety of chiral 1,1'-binaphthyl derivatives with one or two hydroxyl groups at either the 2,2'-(minor groove) or the 7,7'-positions (major groove) were prepared for enantioselective recognition of the cinchona alkaloids quinine and quinidine. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1966b68cf046cf7651731f36780a02f
https://doi.org/10.1021/jo00090a037
https://doi.org/10.1021/jo00090a037
Autor:
Hugh Rosen, John R. Teijaro, Fiona Scott, Daniel M. Fremgen, Kevin B. Walsh, Edward Roberts, Esther Martinborough, Michael B. A. Oldstone, Robert Peach, Stuart M. Cahalan
Publikováno v:
Cell
Cytokine storm during viral infection is a prospective predictor of morbidity and mortality, yet the cellular sources remain undefined. Here, using genetic and chemical tools to probe functions of the S1P(1) receptor, we elucidate cellular and signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8950d2d3a7f5df58fd2b3b4968e2239b
https://pubmed.ncbi.nlm.nih.gov/21925310
https://pubmed.ncbi.nlm.nih.gov/21925310
Autor:
Esther Martinborough, Frank P. Bell, Charles H. Spilman, Scott D. Larsen, Dac M. Dinh, Gracella J. Wilson
Publikováno v:
ChemInform. 22
A novel series of 6,7-dihydro-4H-pyrazolo [1,5-a] pyrrolo [3,4-d] pyrimidine-5,8-dione inhibitors of the enzyme acyl-CoA: cholesterol O-acyltransferase is described. A number of these derivatives were found to obe potent modulators of serum lipoprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7edc2f2a72e5c81d071796ca79848378
https://doi.org/10.1002/chin.199145196
https://doi.org/10.1002/chin.199145196
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dce3940eda64e9dd398181b9a41ccbe5
https://doi.org/10.1002/chin.199831203
https://doi.org/10.1002/chin.199831203
Publisher Summary This chapter summarizes developments within the voltage-gated sodium channel (VGSC) field focusing on the structural classes. The nine VGSCs (NaV1.1–1.9) discovered to date are members of a larger voltage-gated ion channel super-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d615f045d0e2f8b74de7595e0e41b65
https://doi.org/10.1016/s0065-7743(08)00003-1
https://doi.org/10.1016/s0065-7743(08)00003-1
Autor:
Esther Martinborough, and Andrés Negro-Vilar, Keith B. Marschke, Thomas Lau, William Y. Chang, Yixing Shen, Francisco J. López, O. Humberto Viveros, Peter J. Rix, Eric G. Vajda, Arjan van Oeveren, Yun Oliver Long, Lin Zhi
Publikováno v:
Journal of medicinal chemistry. 50(21)
The androgen receptor is a ligand inducible transcription factor that is involved in a broad range of physiological functions. Here we describe the discovery of a new class of orally available selective androgen receptor modulators. The lead compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b3a007cbb7644aace7d9a6250ceb4a
https://pubmed.ncbi.nlm.nih.gov/17887661
https://pubmed.ncbi.nlm.nih.gov/17887661
Autor:
Lin Zhi, Esther Martinborough
Publisher Summary This chapter examines the different aspects of selective androgen receptor modulators (SARMS). Testosterone (T) is an endogenous ligand for the androgen receptor (AR) and is essential for the development and maintenance of the male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a3c0638a0d190f9506eb83896f6c5d2
https://doi.org/10.1016/s0065-7743(01)36057-8
https://doi.org/10.1016/s0065-7743(01)36057-8