Výsledky vyhledávání

Autophagy Is Differentially Regulated in Leukocyte and Nonleukocyte Foam Cells During Atherosclerosis

Autor: Sabrina Robichaud, Adil Rasheed, Antonietta Pietrangelo, Anne Doyoung Kim, Dominique M. Boucher, Christina Emerton, Viyashini Vijithakumar, Lara Gharibeh, Garrett Fairman, Esther Mak, My-Anh Nguyen, Michele Geoffrion, Robert Wirka, Katey J. Rayner, Mireille Ouimet

Publikováno v: Circ Res

Rationale: Atherosclerosis is characterized by an accumulation of foam cells within the arterial wall, resulting from excess cholesterol uptake and buildup of cytosolic lipid droplets (LDs). Autophagy promotes LD clearance by freeing stored cholester

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00aa5059b87fa789fffff2b6079635e
https://doi.org/10.1161/circresaha.121.320047

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Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells

Autor: Alexander R. Pelletier, Viyashini Vijithakumar, Sabrina Robichaud, Sylvain Huard, Mathieu Lavallée-Adam, Daniel Figeys, David P. Cook, Barbara C. Vanderhyden, Garrett Fairman, Mireille Ouimet, Esther Mak, Kristin Baetz

Publikováno v: Autophagy
article-version (VoR) Version of Record

Macrophage autophagy is a highly anti-atherogenic process that promotes the catabolism of cytosolic lipid droplets (LDs) to maintain cellular lipid homeostasis. Selective autophagy relies on tags such as ubiquitin and a set of selectivity factors inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41003c5a761b6a6fdaf67d63af57fc37
https://doi.org/10.1080/15548627.2021.1886839

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Abstract 207: Autophagy Is Differentially Regulated In Leukocyte And Nonleukocyte Foam Cells During Atherosclerosis

Autor: Sabrina Robichaud, Adil Rasheed, Antonietta Pietrangelo, Anne Kim, Dominique Boucher, Chrissy Emerton, Viyashini Vijithakumar, Lara Gharibeh, Garrett Fairman, Esther Mak, My-anh Nguyen, Michele Geoffrion, Robert Wirka, Katey J Rayner, Mireille I Ouimet

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 42

Atherosclerosis is characterized by a build-up of foam cells in the arterial wall, resulting from excess cholesterol uptake and accumulation of cytosolic lipid droplets (LDs). Autophagy has been shown to be atheroprotective in part by promoting the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::122d4f857f772e9ab70e43afa71da7be
https://doi.org/10.1161/atvb.42.suppl_1.207

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Abstract 102: Autophagy Is Differentially Regulated In Leukocyte And Nonleukocyte Foam Cells During Atherosclerosis

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 42

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0d884b30d67de0fd356e4e511dfbfac
https://doi.org/10.1161/atvb.42.suppl_1.102

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Expression of murine muscle-enriched A-type lamin-interacting protein (MLIP) is regulated by tissue-specific alternative transcription start sites

Autor: Esther Mak, Jonathan J. Weldrick, Gayashan Tennakoon, Patrick G. Burgon, Rishi B Gupta, Marie-Elodie Cattin, Shelley A. Deeke, Sarah A. Dick, Cassandra L. Roeske, Lynn A. Megeney, Zachary J.A. Verret-Borsos

Publikováno v: Journal of Biological Chemistry. 293:19761-19770

Muscle-enriched lamin-interacting protein (Mlip) is an alternatively spliced gene whose splicing specificity is dictated by tissue type. MLIP is most abundantly expressed in brain, cardiac, and skeletal muscle. In the present study, we systematically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b5b26360c62e65d97cfe40cc9f3a74
https://doi.org/10.1074/jbc.ra118.003758

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Akademický článek

Rural livelihoods and land reform in South Africa: An intersectional perspective on women's lived experiences

Autor: Esther Makhetha

Publikováno v: Social Sciences and Humanities Open, Vol 10, Iss , Pp 101037- (2024)

Through racialised discrimination under colonialism and apartheid, black people in South Africa were dispossessed of their land. They were often forced into cheap labour for the new mining economic complex and industrial sector. Land dispossession wa

Externí odkaz: https://doaj.org/article/16c110e3697f426db764039866a2963d

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Deletion of MLIP (Muscle-enriched A-type Lamin-interacting Protein) Leads to Cardiac Hyperactivation of Akt/Mammalian Target of Rapamycin (mTOR) and Impaired Cardiac Adaptation

Autor: Patrick G. Burgon, Jessica Wang, Marie-Elodie Cattin, Esther Mak, Jonathan J. Weldrick, Aldon J. Lusis, Jean N. DaSilva, Stephanie Thorn, Yibin Wang, Cassandra L. Roeske

Publikováno v: The Journal of biological chemistry, vol 290, iss 44

Aging and diseases generally result from tissue inability to maintain homeostasis through adaptation. The adult heart is particularly vulnerable to disequilibrium in homeostasis because its regenerative abilities are limited. Here, we report that MLI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc5d24c9cea13fad010efd5dd00f830
https://doi.org/10.1074/jbc.m115.678433

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Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

Autor: Esther Mak, Xianghai Liao, Vivian Franklin, Mireille Ouimet, Yves L. Marcel, Ira Tabas

Publikováno v: Cell Metabolism. 13:655-667

SummaryThe lipid droplet (LD) is the major site of cholesterol storage in macrophage foam cells and is a potential therapeutic target for the treatment of atherosclerosis. Cholesterol, stored as cholesteryl esters (CEs), is liberated from this organe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f2fec95ace589b6de56310a448a18e
https://doi.org/10.1016/j.cmet.2011.03.023

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p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation

Autor: Stephen J. Tapscott, Kai Ge, LiFang Li, F. Jeffrey Dilworth, Shravanti Rampalli, Esther Mak, Marjorie Brand

Publikováno v: Nature Structural & Molecular Biology. 14:1150-1156

Cell-specific patterns of gene expression are established through the antagonistic functions of trithorax group (TrxG) and Polycomb group (PcG) proteins. Several muscle-specific genes have previously been shown to be epigenetically marked for repress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85709c843dfa20afbe3bf79f0f8e9ed9
https://doi.org/10.1038/nsmb1316

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Abstract 205: Mlip is a New Integrator of Physiological Stress Required For Proper Cardiac Adaptation

Autor: Marie-Elodie Cattin, Jessica Wang, Cassandra Roeske, Esther Mak, Stephanie L Thorn, Jean N DaSilva, Yibin Wang, Aldon J Lusis, Patrick G Burgon

Publikováno v: Circulation Research. 117

Aging and diseases are generally a result of the inability of tissues to properly adapt to stress. The heart is particularly vulnerable to disequilibrium in homeostasis as its regenerative capacities are limited. Many molecular players have been iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c18563c8f03926b7c5ef2ade7888380
https://doi.org/10.1161/res.117.suppl_1.205

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