An Explorative Study on Monocyte Reprogramming in the Context of Periodontitis In Vitro and In Vivo

Autor: Marlies P. Noz, Adelina S. Plachokova, Esther M.M. Smeets, Erik H. J. G. Aarntzen, Siroon Bekkering, Prya Vart, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

AimsPeriodontitis is an independent risk factor for cardiovascular disease, but the mechanistic link is not fully understood. In atherosclerotic cardiovascular disease, monocytes can adopt a persistent hyperresponsive phenotype, termed trained immuni

Externí odkaz: https://doaj.org/article/4f758402748d43c2af5f182ff74e45a4

Arterial Wall Inflammation and Increased Hematopoietic Activity in Patients With Primary Aldosteronism

Autor: Leo A. B. Joosten, Jaap Deinum, Alexander Hoischen, Charlotte D C C van der Heijden, Mihai G. Netea, Marlies P. Noz, Charlotte Kaffa, Esther M.M. Smeets, Simone Kersten, Erik H.J.G. Aarntzen, Houshang Monajemi, Niels P. Riksen

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 105, 5
Journal of Clinical Endocrinology and Metabolism, 105
The Journal of Clinical Endocrinology and Metabolism

Context Primary aldosteronism (PA) confers an increased risk of cardiovascular disease (CVD), independent of blood pressure. Animal models have shown that aldosterone accelerates atherosclerosis through proinflammatory changes in innate immune cells;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63c89ad2b6c093d5938603f99e3db88
https://doi.org/10.1210/clinem/dgz306

Growth differentiation factor 15 levels are similar in primary aldosteronism and essential hypertension and do not predict arterial inflammation

Autor: Niels P. Riksen, Charlotte D C C van der Heijden, Saskia C.A. de Jager, Esther M.M. Smeets, Erik H.J.G. Aarntzen, Marian Wesseling

Publikováno v: Journal of Hypertension, 39, 593-596
Journal of Hypertension, 39, 3, pp. 593-596

Item does not contain fulltext

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8dfb375d4cbfd54562b3b1d2f4de92
https://pubmed.ncbi.nlm.nih.gov/33543888

Reprogramming of bone marrow myeloid progenitor cells in patients with severe coronary artery disease

Autor: Siroon Bekkering, Manita E J Bremmers, Leo A. B. Joosten, Laszlo Groh, Niels van Royen, Niels P. Riksen, Tim Mj Nielen, Erik H.J.G. Aarntzen, Erik Huys, Andreas Schlitzer, Frank Preijers, Marc E. Gomes, Harry Dolstra, Mihai G. Netea, Yang Li, Marlies P. Noz, Evert Jp Lamfers, Saloua El Messaoudi, Esther M.M. Smeets, Walter J.F.M. van der Velden, Bowen Zhang

Publikováno v: eLife
Elife, 9
International
England
eLife 9, e60939 (2020). doi:10.7554/eLife.60939
eLife, Vol 9 (2020)

Atherosclerosis is the major cause of cardiovascular disease (CVD). Monocyte-derived macrophages are the most abundant immune cells in atherosclerotic plaques. In patients with atherosclerotic CVD, leukocytes have a hyperinflammatory phenotype. We hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005eb50e2ac8dbccb328ff6ffbec0a2c
https://pubmed.ncbi.nlm.nih.gov/33168134

Optimal respiratory-gated [18F]FDG PET/CT significantly impacts the quantification of metabolic parameters and their correlation with overall survival in patients with pancreatic ductal adenocarcinoma

Autor: Esther M.M. Smeets, Kees van Laarhoven, Willem Grootjans, Martin Gotthardt, John J. Hermans, Lioe-Fee de Geus-Oei, Dominique S. Withaar, Erik H.J.G. Aarntzen

Publikováno v: EJNMMI Research, 9:24. Springer
Ejnmmi Research, 9
EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)
EJNMMI Research, 9

Purpose Metabolic parameters are increasingly being used to characterize tumors. Motion artifacts due to patient respiration introduce uncertainties in quantification of metabolic parameters during positron emission tomography (PET) image acquisition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af37cdeb403a0b5d7093cab8eca02cec
https://research.utwente.nl/en/publications/fd615702-a32c-46da-8d18-a065d62c6930