Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Esther M. Speer"'
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Akademický článek
A Neonatal Murine Escherichia coli Sepsis Model Demonstrates That Adjunctive Pentoxifylline Enhances the Ratio of Anti- vs. Pro-inflammatory Cytokines in Blood and Organ Tissues
Autor: Esther M. Speer, Elizabet Diago-Navarro, Lukasz S. Ozog, Mahnoor Raheel, Ofer Levy, Bettina C. Fries
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Introduction: Neonatal sepsis triggers an inflammatory response that contributes to mortality and multiple organ injury. Pentoxifylline (PTX), a phosphodiesterase inhibitor which suppresses pro-inflammatory cytokines, is a candidate adjunctive therap
Externí odkaz: https://doaj.org/article/1d1e849025ad4ae58935abd260aed09f
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3
A Neonatal Murine Escherichia coli Sepsis Model Demonstrates That Adjunctive Pentoxifylline Enhances the Ratio of Anti- vs. Pro-inflammatory Cytokines in Blood and Organ Tissues
Autor: Ofer Levy, Esther M. Speer, Bettina C Fries, Elizabet Diago-Navarro, Lukasz S. Ozog, Mahnoor Raheel
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Introduction: Neonatal sepsis triggers an inflammatory response that contributes to mortality and multiple organ injury. Pentoxifylline (PTX), a phosphodiesterase inhibitor which suppresses pro-inflammatory cytokines, is a candidate adjunctive therap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef9a4a2e85497182036277a35e22270
https://doi.org/10.3389/fimmu.2020.577878
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4
A Neonatal Murine
Autor: Esther M, Speer, Elizabet, Diago-Navarro, Lukasz S, Ozog, Mahnoor, Raheel, Ofer, Levy, Bettina C, Fries
Publikováno v: Frontiers in Immunology
Introduction: Neonatal sepsis triggers an inflammatory response that contributes to mortality and multiple organ injury. Pentoxifylline (PTX), a phosphodiesterase inhibitor which suppresses pro-inflammatory cytokines, is a candidate adjunctive therap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c2bfc8e088d7a4959b71ff0f86692dd
https://pubmed.ncbi.nlm.nih.gov/33072121
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5
Pentoxifylline inhibits lipopolysaccharide-induced inflammatory mediators in human second trimester placenta explants
Autor: Nazeeh Hanna, Xinhua Lin, Shahidul Islam, Amitasrigowri Murthy, Wei Hou, Esther M. Speer
Publikováno v: Placenta. 58:60-66
Background Intrauterine infection and inflammation during pregnancy, which leads to up-regulation of inflammatory cytokines and prostaglandin synthesis, has been implicated in the pathogenesis of preterm delivery and other pregnancy complications. Ef
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebb4e0294d8ff7a10266da9df9462b0
https://doi.org/10.1016/j.placenta.2017.08.006
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6
Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns
Autor: Lukasz S. Ozog, Esther M. Speer, David J. Dowling, Jie Yang, Ofer Levy, Geetika Kennady, Jianjin Xu
Publikováno v: Pediatric Research. 81:806-816
Toll-like receptor (TLR)-mediated inflammation may contribute to neonatal sepsis, for which pentoxifylline (PTX), a phosphodiesterase inhibitor that raises intracellular cAMP, is a candidate adjunctive therapy. We characterized the anti-inflammatory
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fb671f6564c3cfdce3971f89a1a0bf
https://doi.org/10.1038/pr.2017.6
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7
Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro
Autor: Avinash Chander, Donglei Yin, Esther M. Speer, Jianjin Xu, Ofer Levy, Lukasz S. Ozog, Jaime A. Mathew, David J. Dowling
Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0196352 (2018)
Introduction Neonatal inflammation, mediated in part through Toll-like receptor (TLR) and inflammasome signaling, contributes to adverse outcomes including organ injury. Pentoxifylline (PTX), a phosphodiesterase inhibitor which potently suppresses cy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8dba4093e1f681e1b7557d5309da96
http://europepmc.org/articles/PMC5929513
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8
Akademický článek
Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro.
Autor: Esther M Speer, David J Dowling, Jianjin Xu, Lukasz S Ozog, Jaime A Mathew, Avinash Chander, Donglei Yin, Ofer Levy
Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0196352 (2018)
Neonatal inflammation, mediated in part through Toll-like receptor (TLR) and inflammasome signaling, contributes to adverse outcomes including organ injury. Pentoxifylline (PTX), a phosphodiesterase inhibitor which potently suppresses cytokine produc
Externí odkaz: https://doaj.org/article/84edc266cb8b42bd83c2789ada13676f
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