Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Esther M. Lien"'
Autor:
Shengzhe Zhang, Sung Ho Lee, Litong Nie, Yuanjian Huang, Gengyi Zou, Youn‐Sang Jung, Sohee Jun, Jie Zhang, Esther M. Lien, Junjie Chen, Jae‐Il Park
Publikováno v:
Cancer Communications, Vol 43, Iss 1, Pp 159-163 (2023)
Externí odkaz:
https://doaj.org/article/f5ab10a75cbc4938a7ae90dba61d3d84
Autor:
Shengzhe Zhang, Sung Ho Lee, Litong Nie, Youn-Sang Jung, Sohee Jun, Jie Zhang, Esther M Lien, Junjie Chen, Jae-Il Park
Publikováno v:
Cancer Research. 82:P5-08
Increasing evidence suggests that the deregulated lysosomes contribute to tumorigenesis and therapeutic resistance. However, its underlying mechanisms remain elusive. Here, we identify transmembrane protein 9 (TMEM9) as a regulator involved in lysoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fdd27d520cb298e894d6a49a20e42e9
https://doi.org/10.1158/1538-7445.sabcs21-p5-08-15
https://doi.org/10.1158/1538-7445.sabcs21-p5-08-15
Publikováno v:
Cell Reports, Vol 21, Iss 9, Pp 2571-2584 (2017)
Fine control of stem cell maintenance and activation is crucial for tissue homeostasis and regeneration. However, the mechanism of quiescence exit of Tert+ intestinal stem cells (ISCs) remains unknown. Employing a Tert knockin (TertTCE/+) mouse model
Externí odkaz:
https://doaj.org/article/1ec691de2569476b918fb9df5f3cdf24
Autor:
Sohee Jun, Youn-Sang Jung, Han Na Suh, Wenqi Wang, Moon Jong Kim, Young Sun Oh, Esther M. Lien, Xi Shen, Yoshihisa Matsumoto, Pierre D. McCrea, Lei Li, Junjie Chen, Jae-Il Park
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The Wnt/β-catenin signalling pathway contributes to radio resistance in intestinal stem cells but the underlying mechanism is currently unknown. In this study, the authors demonstrate that LIG4, a DNA ligase involved in the DNA repair process, is a
Externí odkaz:
https://doaj.org/article/581765a279824025a9bb4b79da323deb
Autor:
Sung Ho Lee, Pierre D. McCrea, Wenqi Wang, Han Na Suh, Moon Jong Kim, Jung In Yang, Sun-Hye Lee, Youn Sang Jung, Esther M. Lien, Jie Zhang, Rachel K. Miller, Sohee Jun, Ji Yuan Wu, Hong Ji, Hae Yun Jung, Jae Il Park, Scott Kopetz, Junjie Chen
Publikováno v:
Nature Cell Biology. 20:1421-1433
Vesicular acidification and trafficking are associated with various cellular processes. However, their pathologic relevance to cancer remains elusive. We identified transmembrane protein 9 (TMEM9) as a vesicular acidification regulator. TMEM9 is high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0243e1ebabaa384b296a1f6dd0153b58
https://doi.org/10.1038/s41556-018-0219-8
https://doi.org/10.1038/s41556-018-0219-8
Autor:
Youn Sang Jung, Wenqi Wang, Joan Shang, Jie Zhang, Songlin Zhang, Esther M. Lien, Mrinal Srivastava, Jae Il Park, Moon Jong Kim, Sohee Jun, Pierre D. McCrea, Junjie Chen
Publikováno v:
Nature Cell Biology. 20:1303-1314
Epithelial integrity is maintained by the cytoskeleton and through cell adhesion. However, it is not yet known how a deregulated cytoskeleton is associated with cancer. We identified cancer-related regulator of actin dynamics (CRAD) as frequently mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d603d63f4b758d52ef52994fb29819
https://doi.org/10.1038/s41556-018-0215-z
https://doi.org/10.1038/s41556-018-0215-z
Publikováno v:
Cell Reports, Vol 21, Iss 9, Pp 2571-2584 (2017)
Fine control of stem cell maintenance and activation is crucial for tissue homeostasis and regeneration. However, the mechanism of quiescence exit of Tert+ intestinal stem cells (ISCs) remains unknown. Employing a Tert knockin (TertTCE/+) mouse model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fcd2de8a043ce731859b97df0318b7
https://doi.org/10.1016/j.celrep.2017.10.118
https://doi.org/10.1016/j.celrep.2017.10.118
Autor:
Moon Jong Kim, Pierre D. McCrea, Mrianl Srivastava, Youn Sang Jung, Jie Zhang, Joan Shang, Wenqi Wang, Jae Il Park, Songlin Zhang, Esther M. Lien, Sohee Jun, Junjie Chen
Publikováno v:
Cancer Research. 78:4473-4473
Epithelial cell behavior and homeostasis are mainly modulated by the cytoskeleton and cell adhesion. However, much concerning epithelial cell deregulation in cancer remains unknown. We identified Cancer-related Regulator of Actin Dynamics (CRAD) as f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e16f96e1c84899a04be9a0869be7c9bb
https://doi.org/10.1158/1538-7445.am2018-4473
https://doi.org/10.1158/1538-7445.am2018-4473
Autor:
Young Sun Oh, Esther M. Lien, Junjie Chen, Youn Sang Jung, Han Na Suh, Yoshihisa Matsumoto, Sohee Jun, Xi Shen, Moon Jong Kim, Jae Il Park, Pierre D. McCrea, Lei Li, Wenqi Wang
Publikováno v:
Nature Communications
Nature communications, vol 7, iss 1
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature communications, vol 7, iss 1
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Despite the implication of Wnt signalling in radioresistance, the underlying mechanisms are unknown. Here we find that high Wnt signalling is associated with radioresistance in colorectal cancer (CRC) cells and intestinal stem cells (ISCs). We find t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9433abece3161d25bbd96df587dbcee
http://europepmc.org/articles/PMC4820809
http://europepmc.org/articles/PMC4820809
Autor:
Han Na Suh, Sung Ho Lee, Bo Xia, Jie Zhang, Kaifu Chen, Moon Jong Kim, Sohee Jun, Esther M. Lien, Jae Il Park
Publikováno v:
Developmental Cell. 44:582-596.e4
The underlying mechanisms of how self-renewing cells are controlled in regenerating tissues and cancer remain ambiguous. PCNA-associated factor (PAF) modulates DNA repair via PCNA. Also, PAF hyperactivates Wnt/β-catenin signaling independently of PC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d02e218c6b0ba87851c21cff2f7a5a
https://doi.org/10.1016/j.devcel.2018.02.010
https://doi.org/10.1016/j.devcel.2018.02.010