Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Esther K. Schmitt"'
Autor:
Deyun Qiu, Jinxin V. Pei, James E. O. Rosling, Vandana Thathy, Dongdi Li, Yi Xue, John D. Tanner, Jocelyn Sietsma Penington, Yi Tong Vincent Aw, Jessica Yi Han Aw, Guoyue Xu, Abhai K. Tripathi, Nina F. Gnadig, Tomas Yeo, Kate J. Fairhurst, Barbara H. Stokes, James M. Murithi, Krittikorn Kümpornsin, Heath Hasemer, Adelaide S. M. Dennis, Melanie C. Ridgway, Esther K. Schmitt, Judith Straimer, Anthony T. Papenfuss, Marcus C. S. Lee, Ben Corry, Photini Sinnis, David A. Fidock, Giel G. van Dooren, Kiaran Kirk, Adele M. Lehane
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
In a recent clinical trial for oral administration of cipargamin in individuals with malaria, there was an emergence of recrudescent parasites with a G358S mutation in PfATP4. In this work, the authors investigate the effect of this mutation on the f
Externí odkaz:
https://doaj.org/article/7abacde286514d8b929ffa3fbc4d3a0f
Autor:
Gilles Ndayisaba, Adoke Yeka, Kwaku Poku Asante, Martin P. Grobusch, Etienne Karita, Henry Mugerwa, Stephen Asiimwe, Abraham Oduro, Bakary Fofana, Seydou Doumbia, Jay Prakash Jain, Sarita Barsainya, Gerd A. Kullak-Ublick, Guoqin Su, Esther K. Schmitt, Katalin Csermak, Preetam Gandhi, David Hughes
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021)
Abstract Background The novel anti-malarial cipargamin (KAE609) has potent, rapid activity against Plasmodium falciparum. Transient asymptomatic liver function test elevations were previously observed in cipargamin-treated subjects in two trials: one
Externí odkaz:
https://doaj.org/article/890ef9801b434e61bb32253a0c40d2ec
Autor:
Adoke Yeka, Judith Straimer, Guoqin Su, Martin P. Grobusch, Kwaku Poku Asante, Vinay Kumar Venishetty, Sarfaraz Sayyed, Stephen Asiimwe, Gilles F. Ndayisaba, Sarita Barsainya, Abraham Oduro, Caroline Boulton, Henry Mugerwa, Esther K. Schmitt, Etienne Karita, Katalin Csermak Renner, Seydou Doumbia, P. Gandhi, Ivan Demin, Bakary Fofana
Publikováno v:
Clinical infectious diseases. Oxford University Press
Background Cipargamin (KAE609) is a potent antimalarial in a phase II trial. Here we report efficacy, pharmacokinetics, and resistance marker analysis across a range of cipargamin doses. These were secondary endpoints from a study primarily conducted
Publikováno v:
The Journal of infectious diseases. 225(8)
In Southeast Asia, mutations in the Plasmodium falciparum K13 gene have led to delayed parasite clearance and treatment failures in patients with malaria receiving artemisinin combination therapies. Until recently, relevant K13 mutations had been mos
The early preclinical and clinical development of cipargamin (KAE609), a novel antimalarial compound
Autor:
Martin P. Grobusch, Suzan A. M. Bouwman, Rella Zoleko-Manego, Ghyslain Mombo-Ngoma, Esther K. Schmitt, Katalin Csermak Renner
Publikováno v:
Travel medicine and infectious disease, 36:101765. Elsevier USA
Background Cipargamin (KAE609) is a novel spiroindolone class drug for the treatment of malaria, currently undergoing phase 2 clinical development. This review provides an overview and interpretation of the pre-clinical and clinical data of this poss
Autor:
Esther K. Schmitt, Christian Studer, Patrick Rollin, Madeleine Livendahl, Beatrice Ranieri, Marion Rusch, Carsten Spanka, Arnaud Thevenon, Thomas Aust, Maude Patoor, Laure C. Bouchez, Karl Gademann, Dominic Hoepfner
Publikováno v:
ChemBioChem.
Selective and specific inhibitors of Plasmodium falciparum lysyl-tRNA synthetase represent promising therapeutic antimalarial avenues. Cladosporin was identified as a potent P. falciparum lysyl-tRNA synthetase inhibitor, with an activity against para
Autor:
Holed Juboi, Phil Arnold, Jean-Jacques Sanglier, Ann Anni Basik, Esther K. Schmitt, Sunita Sara Gill Shamsul, Tiong Chia Yeo
Publikováno v:
International Journal of Systematic and Evolutionary Microbiology. 65:4113-4120
The taxonomic position of an actinobacterium strain, C296001T, isolated from a soil sample collected in Sarawak, Malaysia, was established using a polyphasic approach. Phylogenetically, strain C296001Twas closely associated with the genusLuteipulvera
Autor:
Patrick Caffrey, Renzo Kottmann, Eriko Takano, Sean Doyle, Axel A. Brakhage, Matthew Cummings, Juan Pablo Gomez-Escribano, Yvonne Mast, Ryan F. Seipke, Rob Lavigne, Markus Nett, Hans-Wilhelm Nützmann, Jan Claesen, David H. Sherman, Daniel Petras, Pablo Cruz-Morales, Carl J. Balibar, Anne Osbourn, Oscar P. Kuipers, Leonilde M. Moreira, Xinyu Liu, Marcia S. Osburne, Bohdan Ostash, David P. Fewer, Changsheng Zhang, Pelin Yilmaz, Mohamed S. Donia, Anja Greule, Hyun Uk Kim, Nicholas J. Tobias, Frank Oliver Glöckner, Christoph Geiger, Chia Y. Lee, William H. Gerwick, Philipp Wiemann, Bertolt Gust, Susan E. Jensen, Wilfred A. van der Donk, Jan Kormanec, Ben Shen, Christopher M. Thomas, Jason Micklefield, Srikanth Duddela, R. Cameron Coates, René De Mot, Anthony S. Haines, Neha Garg, Guohui Pan, Roderich D. Süssmuth, Hyung Jin Kwon, Jonathan D. Walton, Lena Gerwick, Jörn Piel, Monika Ehling-Schulz, Zhenhua Tian, Jonathan L. Klassen, Xiaohui Yan, Emily A. Monroe, Yunchang Xie, Russell J. Cox, Keishi Ishida, Grace Yim, Stefano Donadio, Nadine Ziemert, Yuta Tsunematsu, Matthew L. Hillwig, Miroslav Petricek, Sylvie Lautru, Tilmann Weber, Andrew W. Truman, Rainer Breitling, Peter Kötter, Nikos C. Kyrpides, Stephanie Düsterhus, Christian Hertweck, Hideaki Oikawa, Sean F. Brady, Christopher T. Walsh, Adam C. Jones, Marcus A. Moore, Bradley S. Moore, Barrie Wilkinson, Simone M. Mantovani, Nathan A. Moss, Elizabeth E. Wyckoff, Emily P. Balskus, Kapil Tahlan, Fengan Yu, Monica Höfte, Jos M. Raaijmakers, Taifo Mahmud, Yit-Heng Chooi, Yi Tang, Andreas Bechthold, Douglas A. Mitchell, Joanne M. Willey, Helge B. Bode, John B. Biggins, Margherita Sosio, Yi-Qiang Cheng, Carmen Méndez, Leonard Kaysser, Joleen Masschelein, Daniel Krug, Federico Rosconi, Marnix H. Medema, Kaarina Sivonen, Tomohisa Kuzuyama, Mikko Metsä-Ketelä, Esther K. Schmitt, Carsten Kegler, Andriy Luzhetskyy, Gilles P. van Wezel, Bai Linquan, Kai Blin, Jens Nielsen, Bertrand Aigle, Amrita Pati, Harald Gross, Muriel Viaud, Pieter C. Dorrestein, Carla S. Jones, Michael A. Fischbach, Shelley M. Payne, Zhe Rui, Gerard D. Wright, Wen Liu, Alexey V. Melnik, Barry Scott, Brett A. Neilan, Nancy P. Keller, Rainer Borriss, Katrin Jungmann, Michalis Hadjithomas, Evi Stegmann, Daniel J. Edwards, F. Jerry Reen, Alexander Kristian Apel, Wolfgang Wohlleben, Michael J. Smanski, Leonard Katz, Fergal O'Gara, Eric J. N. Helfrich, Sergey B. Zotchev, Olivier Ploux, Arnold J. M. Driessen, Rolf Müller, Jean-Luc Pernodet, K. D. Entian, José A. Salas, Irene de Bruijn, Francisco Barona-Gómez, Jianhua Ju, Jon Clardy
Publikováno v:
Nature Chemical Biology, 11(9), 625-631. Nature Publishing Group
Nature Chemical Biology 11 (2015), Nr. 9
Medema, M H, Kottmann, R, Yilmaz, P, Cummings, M, Biggins, J B, Blin, K, Bruijn, I D, Chooi, Y H, Claesen, J, Coates, R C, Cruz-Morales, P, Duddela, S, Düsterhus, S, Edwards, D J, Fewer, D P, Garg, N, Geiger, C, Gomez-Escribano, J P, Greule, A, Hadjithomas, M, Haines, A S, Helfrich, E J N, Hillwig, M L, Ishida, K, Jones, A C, Jones, C S, Jungmann, K, Kegler, C, Kim, H U, Kötter, P, Krug, D, Masschelein, J, Melnik, A V, Mantovani, S M, Monroe, E A, Moore, M, Moss, N, Nützmann, H-W, Pan, G, Pati, A, Petras, D, Reen, F J, Rosconi, F, Rui, Z, Tian, Z, Tobias, N J, Tsunematsu, Y, Wiemann, P, Wyckoff, E, Yan, X, Yim, G, Yu, F, Xie, Y, Aigle, B, Apel, A K, Balibar, C J, Balskus, E P, Barona-Gómez, F, Bechthold, A, Bode, H B, Borriss, R, Brady, S F, Brakhage, A A, Caffrey, P, Cheng, Y-Q, Clardy, J, Cox, R J, Mot, R D, Donadio, S, Donia, M S, Donk, W A V D, Dorrestein, P C, Doyle, S, Driessen, A J M, Ehling-Schulz, M, Entian, K-D, Fischbach, M A, Gerwick, L, Gerwick, W H, Gross, H, Gust, B, Hertweck, C, Höfte, M, Jensen, S E, Ju, J, Katz, L, Kaysser, L, Klassen, J L, Keller, N P, Kormanec, J, Kuipers, O P, Kuzuyama, T, Kyrpides, N C, Kwon, H-J, Lautru, S, Lavigne, R, Lee, C Y, Linquan, B, Liu, X, Liu, W, Luzhetskyy, A, Mahmud, T, Mast, Y, Méndez, C, Metsä-Ketelä, M, Micklefield, J, Mitchell, D A, Moore, B S, Moreira, L M, Müller, R, Neilan, B A, Nett, M, Nielsen, J, O'Gara, F, Oikawa, H, Osbourn, A, Osburne, M S, Ostash, B, Payne, S M, Pernodet, J-L, Petricek, M, Piel, J, Ploux, O, Raaijmakers, J M, Salas, J A, Schmitt, E K, Scott, B, Seipke, R F, Shen, B, Sherman, D H, Sivonen, K, Smanski, M J, Sosio, M, Stegmann, E, Süssmuth, R D, Tahlan, K, Thomas, C M, Tang, Y, Truman, A W, Viaud, M, Walton, J D, Walsh, C T, Weber, T, Wezel, G P V, Wilkinson, B, Willey, J M, Wohlleben, W, Wright, G D, Ziemert, N, Zhang, C, Zotchev, S B, Breitling, R, Takano, E & Glöckner, F O 2015, ' Minimum Information about a Biosynthetic Gene cluster ', Nature chemical biology, vol. 11, pp. 625-631 . https://doi.org/10.1038/nchembio.1890
Medema, M H, Kottmann, R, Yilmaz, P, Cummings, M, Biggins, J B, Blin, K, de Bruijn, I, Kim, H U, Nielsen, J & Weber, T 2015, ' Minimum Information about a Biosynthetic Gene cluster ', Nature Chemical Biology, vol. 11, no. 9, pp. 625-631 . https://doi.org/10.1038/nchembio.1890
ResearcherID
Nature Chemical Biology
Nature Chemical Biology, 2015, 11 (9), pp.625-31. ⟨10.1038/nchembio.1890⟩
Nature Chemical Biology, Nature Publishing Group, 2015, 11 (9), pp.625-31. ⟨10.1038/nchembio.1890⟩
Nature Chemical Biology, 11(9), 625-631
Nature Chemical Biology 11 (2015) 9
Scopus
Medema, M H, Kottmann, R, Yilmaz, P, Cummings, M, Biggins, J B, Blin, K, Bruijn, I D, Chooi, Y H, Claesen, J, Coates, R C, Cruz-Morales, P, Duddela, S, Düsterhus, S, Edwards, D J, Fewer, D P, Garg, N, Geiger, C, Gomez-Escribano, J P, Greule, A, Hadjithomas, M, Haines, A S, Helfrich, E J N, Hillwig, M L, Ishida, K, Jones, A C, Jones, C S, Jungmann, K, Kegler, C, Kim, H U, Kötter, P, Krug, D, Masschelein, J, Melnik, A V, Mantovani, S M, Monroe, E A, Moore, M, Moss, N, Nützmann, H-W, Pan, G, Pati, A, Petras, D, Reen, F J, Rosconi, F, Rui, Z, Tian, Z, Tobias, N J, Tsunematsu, Y, Wiemann, P, Wyckoff, E, Yan, X, Yim, G, Yu, F, Xie, Y, Aigle, B, Apel, A K, Balibar, C J, Balskus, E P, Barona-Gómez, F, Bechthold, A, Bode, H B, Borriss, R, Brady, S F, Brakhage, A A, Caffrey, P, Cheng, Y-Q, Clardy, J, Cox, R J, Mot, R D, Donadio, S, Donia, M S, Donk, W A V D, Dorrestein, P C, Doyle, S, Driessen, A J M, Ehling-Schulz, M, Entian, K-D, Fischbach, M A, Gerwick, L, Gerwick, W H, Gross, H, Gust, B, Hertweck, C, Höfte, M, Jensen, S E, Ju, J, Katz, L, Kaysser, L, Klassen, J L, Keller, N P, Kormanec, J, Kuipers, O P, Kuzuyama, T, Kyrpides, N C, Kwon, H-J, Lautru, S, Lavigne, R, Lee, C Y, Linquan, B, Liu, X, Liu, W, Luzhetskyy, A, Mahmud, T, Mast, Y, Méndez, C, Metsä-Ketelä, M, Micklefield, J, Mitchell, D A, Moore, B S, Moreira, L M, Müller, R, Neilan, B A, Nett, M, Nielsen, J, O'Gara, F, Oikawa, H, Osbourn, A, Osburne, M S, Ostash, B, Payne, S M, Pernodet, J-L, Petricek, M, Piel, J, Ploux, O, Raaijmakers, J M, Salas, J A, Schmitt, E K, Scott, B, Seipke, R F, Shen, B, Sherman, D H, Sivonen, K, Smanski, M J, Sosio, M, Stegmann, E, Süssmuth, R D, Tahlan, K, Thomas, C M, Tang, Y, Truman, A W, Viaud, M, Walton, J D, Walsh, C T, Weber, T, Wezel, G P V, Wilkinson, B, Willey, J M, Wohlleben, W, Wright, G D, Ziemert, N, Zhang, C, Zotchev, S B, Breitling, R, Takano, E & Glöckner, F O 2015, ' Minimum Information about a Biosynthetic Gene cluster ' Nature chemical biology, vol. 11, pp. 625-631 . https://doi.org/10.1038/nchembio.1890
Nature Chemical Biology, Nature Publishing Group, 2015, 11 (9), pp.625-31. 〈10.1038/nchembio.1890〉
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Nature Chemical Biology 11 (2015), Nr. 9
Medema, M H, Kottmann, R, Yilmaz, P, Cummings, M, Biggins, J B, Blin, K, Bruijn, I D, Chooi, Y H, Claesen, J, Coates, R C, Cruz-Morales, P, Duddela, S, Düsterhus, S, Edwards, D J, Fewer, D P, Garg, N, Geiger, C, Gomez-Escribano, J P, Greule, A, Hadjithomas, M, Haines, A S, Helfrich, E J N, Hillwig, M L, Ishida, K, Jones, A C, Jones, C S, Jungmann, K, Kegler, C, Kim, H U, Kötter, P, Krug, D, Masschelein, J, Melnik, A V, Mantovani, S M, Monroe, E A, Moore, M, Moss, N, Nützmann, H-W, Pan, G, Pati, A, Petras, D, Reen, F J, Rosconi, F, Rui, Z, Tian, Z, Tobias, N J, Tsunematsu, Y, Wiemann, P, Wyckoff, E, Yan, X, Yim, G, Yu, F, Xie, Y, Aigle, B, Apel, A K, Balibar, C J, Balskus, E P, Barona-Gómez, F, Bechthold, A, Bode, H B, Borriss, R, Brady, S F, Brakhage, A A, Caffrey, P, Cheng, Y-Q, Clardy, J, Cox, R J, Mot, R D, Donadio, S, Donia, M S, Donk, W A V D, Dorrestein, P C, Doyle, S, Driessen, A J M, Ehling-Schulz, M, Entian, K-D, Fischbach, M A, Gerwick, L, Gerwick, W H, Gross, H, Gust, B, Hertweck, C, Höfte, M, Jensen, S E, Ju, J, Katz, L, Kaysser, L, Klassen, J L, Keller, N P, Kormanec, J, Kuipers, O P, Kuzuyama, T, Kyrpides, N C, Kwon, H-J, Lautru, S, Lavigne, R, Lee, C Y, Linquan, B, Liu, X, Liu, W, Luzhetskyy, A, Mahmud, T, Mast, Y, Méndez, C, Metsä-Ketelä, M, Micklefield, J, Mitchell, D A, Moore, B S, Moreira, L M, Müller, R, Neilan, B A, Nett, M, Nielsen, J, O'Gara, F, Oikawa, H, Osbourn, A, Osburne, M S, Ostash, B, Payne, S M, Pernodet, J-L, Petricek, M, Piel, J, Ploux, O, Raaijmakers, J M, Salas, J A, Schmitt, E K, Scott, B, Seipke, R F, Shen, B, Sherman, D H, Sivonen, K, Smanski, M J, Sosio, M, Stegmann, E, Süssmuth, R D, Tahlan, K, Thomas, C M, Tang, Y, Truman, A W, Viaud, M, Walton, J D, Walsh, C T, Weber, T, Wezel, G P V, Wilkinson, B, Willey, J M, Wohlleben, W, Wright, G D, Ziemert, N, Zhang, C, Zotchev, S B, Breitling, R, Takano, E & Glöckner, F O 2015, ' Minimum Information about a Biosynthetic Gene cluster ', Nature chemical biology, vol. 11, pp. 625-631 . https://doi.org/10.1038/nchembio.1890
Medema, M H, Kottmann, R, Yilmaz, P, Cummings, M, Biggins, J B, Blin, K, de Bruijn, I, Kim, H U, Nielsen, J & Weber, T 2015, ' Minimum Information about a Biosynthetic Gene cluster ', Nature Chemical Biology, vol. 11, no. 9, pp. 625-631 . https://doi.org/10.1038/nchembio.1890
ResearcherID
Nature Chemical Biology
Nature Chemical Biology, 2015, 11 (9), pp.625-31. ⟨10.1038/nchembio.1890⟩
Nature Chemical Biology, Nature Publishing Group, 2015, 11 (9), pp.625-31. ⟨10.1038/nchembio.1890⟩
Nature Chemical Biology, 11(9), 625-631
Nature Chemical Biology 11 (2015) 9
Scopus
Medema, M H, Kottmann, R, Yilmaz, P, Cummings, M, Biggins, J B, Blin, K, Bruijn, I D, Chooi, Y H, Claesen, J, Coates, R C, Cruz-Morales, P, Duddela, S, Düsterhus, S, Edwards, D J, Fewer, D P, Garg, N, Geiger, C, Gomez-Escribano, J P, Greule, A, Hadjithomas, M, Haines, A S, Helfrich, E J N, Hillwig, M L, Ishida, K, Jones, A C, Jones, C S, Jungmann, K, Kegler, C, Kim, H U, Kötter, P, Krug, D, Masschelein, J, Melnik, A V, Mantovani, S M, Monroe, E A, Moore, M, Moss, N, Nützmann, H-W, Pan, G, Pati, A, Petras, D, Reen, F J, Rosconi, F, Rui, Z, Tian, Z, Tobias, N J, Tsunematsu, Y, Wiemann, P, Wyckoff, E, Yan, X, Yim, G, Yu, F, Xie, Y, Aigle, B, Apel, A K, Balibar, C J, Balskus, E P, Barona-Gómez, F, Bechthold, A, Bode, H B, Borriss, R, Brady, S F, Brakhage, A A, Caffrey, P, Cheng, Y-Q, Clardy, J, Cox, R J, Mot, R D, Donadio, S, Donia, M S, Donk, W A V D, Dorrestein, P C, Doyle, S, Driessen, A J M, Ehling-Schulz, M, Entian, K-D, Fischbach, M A, Gerwick, L, Gerwick, W H, Gross, H, Gust, B, Hertweck, C, Höfte, M, Jensen, S E, Ju, J, Katz, L, Kaysser, L, Klassen, J L, Keller, N P, Kormanec, J, Kuipers, O P, Kuzuyama, T, Kyrpides, N C, Kwon, H-J, Lautru, S, Lavigne, R, Lee, C Y, Linquan, B, Liu, X, Liu, W, Luzhetskyy, A, Mahmud, T, Mast, Y, Méndez, C, Metsä-Ketelä, M, Micklefield, J, Mitchell, D A, Moore, B S, Moreira, L M, Müller, R, Neilan, B A, Nett, M, Nielsen, J, O'Gara, F, Oikawa, H, Osbourn, A, Osburne, M S, Ostash, B, Payne, S M, Pernodet, J-L, Petricek, M, Piel, J, Ploux, O, Raaijmakers, J M, Salas, J A, Schmitt, E K, Scott, B, Seipke, R F, Shen, B, Sherman, D H, Sivonen, K, Smanski, M J, Sosio, M, Stegmann, E, Süssmuth, R D, Tahlan, K, Thomas, C M, Tang, Y, Truman, A W, Viaud, M, Walton, J D, Walsh, C T, Weber, T, Wezel, G P V, Wilkinson, B, Willey, J M, Wohlleben, W, Wright, G D, Ziemert, N, Zhang, C, Zotchev, S B, Breitling, R, Takano, E & Glöckner, F O 2015, ' Minimum Information about a Biosynthetic Gene cluster ' Nature chemical biology, vol. 11, pp. 625-631 . https://doi.org/10.1038/nchembio.1890
Nature Chemical Biology, Nature Publishing Group, 2015, 11 (9), pp.625-31. 〈10.1038/nchembio.1890〉
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
M.H.M. was supported by a Rubicon fellowship of the Netherlands Organization for Scientific Research (NWO;Rubicon 825.13.001). The work of R.K. was supported by the European Union’s Seventh Framework Programme(Joint Call OCEAN.2011–2: Marine micr
Autor:
Christopher Quinn, Pascal D. Fortin, Christina A. Kirby, Heather Sadlish, Christian Studer, Franklin Chung, Douglas Frederick Quinn, Jinyun Chen, Wenlai Zhou, Raymond Pagliarini, D. Randal Kipp, Travis Stams, Yaoyu Chen, N. Rao Movva, Esther K. Schmitt, Frank Petersen, Ralph Riedl, Tim Schuhmann, Roman Kityk, Dominic Hoepfner, Anne Schitter, Jason Baird, A. Quamrul Hassan, Matthias P. Mayer
Publikováno v:
Chemistry & Biology. 22(1):87-97
Summary The highly conserved 70 kDa heat shock proteins (Hsp70) play an integral role in proteostasis such that dysregulation has been implicated in numerous diseases. Elucidating the precise role of Hsp70 family members in the cellular context, howe