Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Esther K, Kemper"'
Publikováno v:
Nature methods. 19(3)
Proteomics has revealed that the ~20,000 human genes engender a far greater number of proteins, or proteoforms, that are diversified in large part by post-translational modifications (PTMs). How such PTMs affect protein structure and function is an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f94df497414ac127b5ceaac8ae41a237
https://pubmed.ncbi.nlm.nih.gov/35228728
https://pubmed.ncbi.nlm.nih.gov/35228728
Autor:
Luke L. Lairson, Sifei Yin, Dave Remillard, Vincent M. Crowley, Ekaterina V. Vinogradova, Gabriel M. Simon, Giulia Bianco, Megan M. Blewett, Yujia Wang, Radu M. Suciu, Michael R. Lazear, Melissa M. Dix, Stefano Forli, Yu Yamashita, Daniel C. Lazar, Maxim N. Shokhirev, Nhan Nguyen, John R. Teijaro, Benjamin F. Cravatt, Kenneth M. Lum, Esther K. Kemper, Emily N. Chin
Electrophilic compounds originating from nature or chemical synthesis have profound effects on immune cells. These compounds are thought to act by cysteine modification to alter the functions of immune-relevant proteins; however, our understanding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9699760a89f5fdcbd0e8820778a48f0a
https://doi.org/10.1101/808113
https://doi.org/10.1101/808113
Autor:
Minoru Yokoyama, Stuart L. Schreiber, Xiaoyu Zhang, Kenneth M. Lum, Benjamin F. Cravatt, Emily N. Chin, Bruno Melillo, Daniel C. Lazar, Nhan T. Nguyen, Maxim N. Shokhirev, Luke L. Lairson, Sifei Yin, Michael R. Lazear, Stefano Forli, Esther K. Kemper, Gabriel M. Simon, Vincent M. Crowley, Yu Yamashita, David Remillard, Megan M. Blewett, Michael A. Schafroth, John R. Teijaro, David B. Konrad, Giulia Bianco, Yujia Wang, Radu M. Suciu, Melissa M. Dix, Ekaterina V. Vinogradova
Publikováno v:
Cell
Summary Electrophilic compounds originating from nature or chemical synthesis have profound effects on immune cells. These compounds are thought to act by cysteine modification to alter the functions of immune-relevant proteins; however, our understa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d65673df8754b1e83ca7c8b4bfa6833
https://doi.org/10.1016/j.cell.2020.07.001
https://doi.org/10.1016/j.cell.2020.07.001
Publikováno v:
The Journal of Immunology. 204:162.7-162.7
To prime T cells to fight cancer, dendritic cells (DCs) require Type I Interferon (IFN-I) signaling. IFN-I signaling induces the transcription and translation of Interferon Stimulated Genes (ISGs), including strong induction of Usp18, which dampens f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0f983fee0b05d6db8975daa0ad7f900
https://doi.org/10.4049/jimmunol.204.supp.162.7
https://doi.org/10.4049/jimmunol.204.supp.162.7
Publikováno v:
Molecular Cancer Therapeutics. 16:PR16-PR16
The b-ZIP transcription factor NRF2 is a master regulator of the cellular antioxidant response and frequently activated in Non-Small Cell Lung Cancers (NSCLCs). While direct pharmacological inhibition of NRF2 has proven challenging, its aberrant acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a82c534270781859476a17208e4e600
https://doi.org/10.1158/1538-8514.synthleth-pr16
https://doi.org/10.1158/1538-8514.synthleth-pr16
Autor:
Ping Jiang, Enrique Saez, Benjamin D. Horning, Radu M. Suciu, Esther K. Kemper, Thomas A Paul, Keriann M. Backus, Jose Olucha, Liron Bar-Peled, Melissa M. Dix, Reuben J. Shaw, Taka-Aki Ichu, Matthew Merrill Hayward, Bernard P. Kok, Ekaterina V. Vinogradova, Nathan T. Ihle, Zhou Zhu, Max W. Chang, Robert U. Svensson, Benjamin F. Cravatt
Publikováno v:
Cell. 171:696-709.e23
The transcription factor NRF2 is a master regulator of the cellular antioxidant response, and it is often genetically activated in non-small-cell lung cancers (NSCLCs) by, for instance, mutations in the negative regulator KEAP1. While direct pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aaf7da3646d9eadb3e6a663c347c9dc
https://doi.org/10.1016/j.cell.2017.08.051
https://doi.org/10.1016/j.cell.2017.08.051