Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Esther Johann"'
Autor:
Patricia Parris, Geraldine Whelan, Anders Burild, Jessica Whritenour, Uma Bruen, Joel Bercu, Courtney Callis, Jessica Graham, Esther Johann, Troy Griffin, Martin Kohan, Elizabeth A. Martin, Melisa Masuda-Herrera, Brad Stanard, Eric Tien, Maureen Cruz, Lee Nagao
Publikováno v:
Critical Reviews in Toxicology. 52:125-138
During the toxicological assessment of extractables and leachables in drug products, localized hazards such as irritation or sensitization may be identified. Typically, because of the low concentration at which leachables occur in pharmaceuticals, ir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a6a7a140e0285b747a1ffba19dc2da
https://doi.org/10.1080/10408444.2022.2065966
https://doi.org/10.1080/10408444.2022.2065966
Autor:
Mohamed Elmasry, Cerys A. Lovatt, Julie C. Holder, Christopher E. Goldring, Hélène Aerts, Christopher A. Schofield, Helga H.J. Gerets, Delphine Hoët, Richard J. Weaver, Eliane Alexandre, Lysiane Richert, Gilles Labbe, Esther Johann, Sébastien Anthérieu, Martina Dorau, Magnus Ingelman-Sundberg, B. Kevin Park, Neil R. Kitteringham, Robert P. Jones, Simone H. Stahl, Philip G. Hewitt, Rowena Sison-Young, Volker M. Lauschke
Publikováno v:
Archives of Toxicology
Assessing the potential of a new drug to cause drug-induced liver injury (DILI) is a challenge for the pharmaceutical industry. We therefore determined whether cell models currently used in safety assessment (HepG2, HepaRG, Upcyte and primary human h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d335b3454c1138eac7bb8f92772b62d0
https://doi.org/10.1007/s00204-016-1745-4
https://doi.org/10.1007/s00204-016-1745-4
Autor:
David R. Mottram, Esther Johann, Eliane Alexandre, Neil R. Kitteringham, Dimitra Mitsa, Robert P. Jones, Philip G. Hewitt, Christopher E. Goldring, Lysiane Richert, Magnus Ingelman-Sundberg, Hélène Aerts, Richard J. Weaver, Rowena Sison-Young, Rosalind E. Jenkins, B. Kevin Park
Publikováno v:
Toxicological Sciences
In vitro preclinical models for the assessment of drug-induced liver injury (DILI) are usually based on cryopreserved primary human hepatocytes (cPHH) or human hepatic tumor-derived cell lines; however, it is unclear how well such cell models reflect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb5a1c22768b6a5df4ceed1503030c5
https://doi.org/10.1093/toxsci/kfv136
https://doi.org/10.1093/toxsci/kfv136
Autor:
Esther Johann, Philip Hewitt
Publikováno v:
Predictive Toxicology: From Vision to Reality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d114288f559359a0f80f16a501c96e56
https://doi.org/10.1002/9783527674183.ch05
https://doi.org/10.1002/9783527674183.ch05
