Season of sampling and season of birth influence serotonin metabolite levels in human cerebrospinal fluid.

Autor: Jurjen J Luykx, Steven C Bakker, Eef Lentjes, Marco P M Boks, Nan van Geloven, Marinus J C Eijkemans, Esther Janson, Eric Strengman, Anne M de Lepper, Herman Westenberg, Kai E Klopper, Hendrik J Hoorn, Harry P M M Gelissen, Julian Jordan, Noortje M Tolenaar, Eric P A van Dongen, Bregt Michel, Lucija Abramovic, Steve Horvath, Teus Kappen, Peter Bruins, Peter Keijzers, Paul Borgdorff, Roel A Ophoff, René S Kahn

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e30497 (2012)

BACKGROUND: Animal studies have revealed seasonal patterns in cerebrospinal fluid (CSF) monoamine (MA) turnover. In humans, no study had systematically assessed seasonal patterns in CSF MA turnover in a large set of healthy adults. METHODOLOGY/PRINCI

Externí odkaz: https://doaj.org/article/f131df95cc434aeb9294f7983f15bdae

Hippocampal gene expression analysis highlights Ly6a/Sca-1 as candidate gene for previously mapped novelty induced behaviors in mice.

Autor: Simone de Jong, Martien J H Kas, Jeffrey Kiernan, Annetrude G de Mooij-van Malsen, Hugo Oppelaar, Esther Janson, Igor Vukobradovic, Charles R Farber, William L Stanford, Roel A Ophoff

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e20716 (2011)

In this study, we show that the covariance between behavior and gene expression in the brain can help further unravel the determinants of neurobehavioral traits. Previously, a QTL for novelty induced motor activity levels was identified on murine chr

Externí odkaz: https://doaj.org/article/bef945617f9a4f0cb28eeeacb080d89c

Imaging gene and environmental effects on cerebellum in Attention-Deficit/Hyperactivity Disorder and typical development

Autor: Esther Janson, Janna van Belle, Bobby P. C. Koeleman, Herman van Engeland, Juliette Weusten, Sarai van Dijk, Sarah Durston, Patrick de Zeeuw

Publikováno v: NeuroImage : Clinical

This study investigates the effects of XKR4, a recently identified candidate gene for Attention-Deficit/Hyperactivity Disorder (ADHD), birth weight, and their interaction on brain volume in ADHD. XKR4 is expressed in cerebellum and low birth weight h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673f339f30ed9b626859e928a2d16d1a
https://doi.org/10.1016/j.nicl.2012.11.010

Investigation of the involvement of MIR185 and its target genes in the development of schizophrenia

Autor: Eric Strengman, Lutz Priebe, Marcella Rietschel, Anne C. Böhmer, David M. Hougaard, Xavier Miró, Stefan Herms, Andreas Zimmer, Roel A. Ophoff, Markus M. Nöthen, Josef Frank, F. B. Basmanav, Per Hoffmann, Dan Rujescu, Stephanie H. Witt, Franziska Degenhardt, Anders D. Børglum, Manuel Mattheisen, Sven Cichon, Rainald Mössner, Andreas J. Forstner, Preben Bo Mortensen, Wolfgang Maier, Susanne Moebus, Mads V. Hollegaard, Esther Janson

Publikováno v: Journal of psychiatry & neuroscience : JPN, vol 39, iss 6
Europe PubMed Central
Forstner, A J, Basmanav, F B, Mattheisen, M, Böhmer, A C, Hollegaard, M V, Janson, E, Strengman, E, Priebe, L, Degenhardt, F, Hoffmann, P, Herms, S, Maier, W, Mössner, R, Rujescu, D, Ophoff, R A, Moebus, S, Mortensen, P B, Børglum, A D, Hougaard, D M, Frank, J, Witt, S H, Rietschel, M, Zimmer, A, Nöthen, M M, Miró, X, Cichon, S & GROUP Investigators 2014, ' Investigation of the involvement of MIR185 and its target genes in the development of schizophrenia ', Journal of Psychiatry and Neuroscience, vol. 39, no. 6, pp. 386-396 . https://doi.org/10.1503/jpn.130189

BACKGROUND: Schizophrenia is a complex neuropsychiatric disorder of unclear etiology. The strongest known genetic risk factor is the 22q11.2 microdeletion. Research has yet to confirm which genes within the deletion region are implicated in schizophr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51fc3dba13904cdd0150d519aa60649f
https://pubmed.ncbi.nlm.nih.gov/24936775

Common inversion polymorphism at 17q21.31 affects expression of multiple genes in tissue-specific manner

Autor: Jan H. Veldink, Simone de Jong, Roel A. Ophoff, Eric Strengman, Esther Janson, Leonard H. van den Berg, Iouri Chepelev

Publikováno v: BMC Genomics, Vol 13, Iss 1, p 458 (2012)
BMC Genomics
de Jong, Simone; Chepelev, Iouri; Janson, Esther; Strengman, Eric; van den Berg, Leonard H; Veldink, Jan H; et al.(2012). Common inversion polymorphism at 17q21.31 affects expression of multiple genes in tissue-specific manner. BMC Genomics, 13(1), 458. doi: http://dx.doi.org/10.1186/1471-2164-13-458. Retrieved from: http://www.escholarship.org/uc/item/2v51t767

Background Chromosome 17q21.31 contains a common inversion polymorphism of approximately 900 kb in populations with European ancestry. Two divergent MAPT haplotypes, H1 and H2 are described with distinct linkage disequilibrium patterns across the reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b326f4f101e673760299e29aa3eb9790
http://www.biomedcentral.com/1471-2164/13/458