Performance of nanoScan PET/CT and PET/MR for quantitative imaging of 18F and 89Zr as compared with ex vivo biodistribution in tumor-bearing mice

Autor: Esther J.M. Kooijman, Marc C. Huisman, Marion Chomet, Albert D. Windhorst, Wissam Beaino, Alex J. Poot, Ricardo Vos, Mariska Verlaan, Guus A.M.S. van Dongen, Ronald Boellaard, Maxime Schreurs, Danielle J. Vugts

Publikováno v: EJNMMI Research, Vol 11, Iss 1, Pp 1-11 (2021)
EJNMMI Research, 11(1). Springer Berlin
EJNMMI Research, 11(1):57. Springer Berlin
Chomet, M, Schreurs, M, Vos, R, Verlaan, M, Kooijman, E J, Poot, A J, Boellaard, R, Windhorst, A D, van Dongen, G A, Vugts, D J, Huisman, M C & Beaino, W 2021, ' Performance of nanoScan PET/CT and PET/MR for quantitative imaging of F-18 and Zr-89 as compared with ex vivo biodistribution in tumor-bearing mice ', EJNMMI Research, vol. 11, no. 1, 57 . https://doi.org/10.1186/s13550-021-00799-2

Introduction The assessment of ex vivo biodistribution is the preferred method for quantification of radiotracers biodistribution in preclinical models, but is not in line with current ethics on animal research. PET imaging allows for noninvasive lon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8d796489bbc7fd5119c31e1fdc00e3
https://doaj.org/article/4f3ec609f1134052bbce1d4d7d199044

Synthesis and evaluation of [18F]cinacalcet for the imaging of parathyroid hyperplasia

Autor: Anna Pees, Esther J.M. Kooijman, Mariska Verlaan, Maxime Schreurs, Wissam Beaino, Anton F. Engelsman, Robert C. Schuit, Maria J. W. D. Vosjan, Albert D. Windhorst, Danielle J. Vugts

Publikováno v: Nuclear Medicine and Biology, 102-103, 97-105. Elsevier Inc.
Pees, A, Beaino, W, Kooijman, E J M, Schreurs, M, Verlaan, M, Schuit, R C, Vosjan, M J W D, Engelsman, A F, Windhorst, A D & Vugts, D J 2021, ' Synthesis and evaluation of [18F]cinacalcet for the imaging of parathyroid hyperplasia ', Nuclear Medicine and Biology, vol. 102-103, pp. 97-105 . https://doi.org/10.1016/j.nucmedbio.2021.10.003, https://doi.org/10.1016/j.nucmedbio.2021.10.003

Introduction Parathyroid hyperplasia is a disease characterized by overactive parathyroid glands secreting increased levels of parathyroid hormone. Surgical removal of the parathyroid glands is the standard treatment but requires precise pre-operativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6eaf11f40f5e084d849e8d20e145ddd
https://research.vumc.nl/en/publications/bf709e8c-8f70-479f-a319-c2af71def317

Evaluation of carbon-11 labeled 5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide as PET tracer for imaging of CSF-1R expression in the brain

Autor: Bin Shen, Esther J.M. Kooijman, Albert D. Windhorst, Frederick T. Chin, Madina Nezam, Samantha T. Reyes, Berend van der Wildt

Publikováno v: Bioorganic and Medicinal Chemistry, 42:116245. Elsevier Limited
van der Wildt, B, Nezam, M, Kooijman, E J M, Reyes, S T, Shen, B, Windhorst, A D & Chin, F T 2021, ' Evaluation of carbon-11 labeled 5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide as PET tracer for imaging of CSF-1R expression in the brain ', Bioorganic and Medicinal Chemistry, vol. 42, 116245 . https://doi.org/10.1016/j.bmc.2021.116245

Pharmacological targeting of tumor associated macrophages and microglia in the tumor microenvironment is a novel therapeutic strategy in the treatment of glioblastoma multiforme. As such, the colony stimulating factor-1 receptor (CSF-1R) has been ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6407f64f503e7d9f00f9d31aa43890
https://pubmed.ncbi.nlm.nih.gov/34119698

Synthesis and preclinical evaluation of [methylpiperazine-11C]brigatinib as a PET imaging agent for mutated EGFR and ALK positive tumors

Autor: Antonia Högnäsbacka, Albert D. Windhorst, Robert C. Schuit, Guus A.M.S. van Dongen, Esther J.M. Kooijman, Mariska Verlaan, Maxime Schreurs, Wissam Beaino, Danielle J. Vugts, Alex J. Poot

Publikováno v: Nuclear Medicine and Biology. :S51-S52

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5682a2796cd0fd2f830dbf6f38e44ce
https://doi.org/10.1016/s0969-8051(21)00347-4

Synthesis, radiolabeling and preclinical evaluation of a [11C]GMOM derivative as PET radiotracer for the ion channel of the N-methyl-D-aspartate receptor

Autor: Johannes A. M. Christiaans, Esther J.M. Kooijman, Bart N.M. van Berckel, Albert D. Windhorst, Pieter J. Klein, Athanasios Metaxas, Adriaan A. Lammertsma, Robert C. Schuit

Publikováno v: Klein, P J, Schuit, R C, Metaxas, A, Christiaans, J AM, Kooijman, E, Lammertsma, A A, van Berckel, B NM & Windhorst, A D 2017, ' Synthesis, radiolabeling and preclinical evaluation of a [ 11 C]GMOM derivative as PET radiotracer for the ion channel of the N-methyl-D-aspartate receptor ', Nuclear Medicine and Biology, vol. 51, pp. 25-32 . https://doi.org/10.1016/j.nucmedbio.2017.05.003
Nuclear Medicine and Biology, 51, 25-32. Elsevier Inc.

Introduction Presently available PET ligands for the NMDAr ion channel generally suffer from fast metabolism. The purpose of this study was to develop a metabolically more stable ligand for the NMDAr ion channel, taking [11C]GMOM ([11C]1) as the lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb0b4933edff4a728bc8b7ba2314f9b
https://doi.org/10.1016/j.nucmedbio.2017.05.003