Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy.

Autor: Bianca C Bernardo, Xiao-Ming Gao, Yow Keat Tham, Helen Kiriazis, Catherine E Winbanks, Jenny Y Y Ooi, Esther J H Boey, Susanna Obad, Sakari Kauppinen, Paul Gregorevic, Xiao-Jun Du, Ruby C Y Lin, Julie R McMullen

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e90337 (2014)

Therapeutic inhibition of the miR-34 family (miR-34a,-b,-c), or miR-34a alone, have emerged as promising strategies for the treatment of cardiac pathology. However, before advancing these approaches further for potential entry into the clinic, a more

Externí odkaz: https://doaj.org/article/8b902a46757b434fbe7761cf030d6d9f

Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling

Autor: Kate L. Weeks, Nelly Cemerlang, Hongwei Qian, Xiao-Jun Du, Helen Kiriazis, Xiao-Ming Gao, Yow Keat Tham, Paul Gregorevic, Thawin Pongsukwechkul, Bianca C. Bernardo, Esther J. H. Boey, Chad Johnson, Julie R. McMullen

Publikováno v: Clinical science (London, England : 1979). 132(3)

We previously showed that medium chain acyl-coenzyme A dehydrogenase (MCAD, key regulator of fatty acid oxidation) is positively modulated in the heart by the cardioprotective kinase, phosphoinositide 3-kinase (PI3K(p110α)). Disturbances in cardiac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95058dfd06fca486c109e2107c6d684
https://pubmed.ncbi.nlm.nih.gov/29358507

Phosphoinositide 3-Kinase p110α Is a Master Regulator of Exercise-Induced Cardioprotection and PI3K Gene Therapy Rescues Cardiac Dysfunction

Autor: Aya Matsumoto, Marie A. Bogoyevitch, Nelly Cemerlang, Xiao-Jun Du, Helen Kiriazis, Xiao-Ming Gao, Elizabeth A. Woodcock, Joon Win Tan, Julie R. McMullen, Thomas F. Franke, Esther J. H. Boey, Paul Gregorevic, Bianca C. Bernardo, Kate L. Weeks, Mark A. Febbraio, Hongwei Qian, Yow Keat Tham

Publikováno v: Circulation: Heart Failure. 5:523-534

Background— Numerous molecular and biochemical changes have been linked with the cardioprotective effects of exercise, including increases in antioxidant enzymes, heat shock proteins, and regulators of cardiac myocyte proliferation. However, a mast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c09da5ddf669032aec91c7fc75eb68
https://doi.org/10.1161/circheartfailure.112.966622

Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy

Autor: Esther J. H. Boey, Enzo R. Porrello, Julie R. McMullen, Paul Gregorevic, Sindhu Igoor, Ruby C.Y. Lin, Jenny Ying Ying Ooi, Yow Keat Tham, Bianca C. Bernardo, Catherine E. Winbanks, Xiao-Jun Du, Helen Kiriazis, Xiao-Ming Gao, Colleen J. Thomas, Sally S. Nguyen

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(12)

Expression of microRNA-652 (miR-652) increases in the diseased heart, decreases in a setting of cardioprotection, and is inversely correlated with heart function. The aim of this study was to assess the therapeutic potential of inhibiting miR-652 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c04f9a218307d3ce7169886f0a8f07
https://pubmed.ncbi.nlm.nih.gov/25145628

Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy

Autor: Susanna Obad, Paul Gregorevic, Yow Keat Tham, Jenny Ying Ying Ooi, Sakari Kauppinen, Ruby C.Y. Lin, Catherine E. Winbanks, Xiao-Jun Du, Xiao-Ming Gao, Bianca C. Bernardo, Helen Kiriazis, Julie R. McMullen, Esther J. H. Boey

Publikováno v: Bernardo, B C, Gao, X-M, Tham, Y K, Kiriazis, H, Winbanks, C E, Ooi, J Y Y, Boey, E J H, Obad, S, Kauppinen, S, Gregorevic, P, Du, X-J, Lin, R C Y & McMullen, J R 2014, ' Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy ', P L o S One, vol. 9, no. 2, e90337 . https://doi.org/10.1371/journal.pone.0090337
PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e90337 (2014)

Therapeutic inhibition of the miR-34 family (miR-34a,-b,-c), or miR-34a alone, have emerged as promising strategies for the treatment of cardiac pathology. However, before advancing these approaches further for potential entry into the clinic, a more

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf2c1a83dc880692ff744a8c5150529
https://vbn.aau.dk/da/publications/4fba6df1-8983-4d31-b6dd-40faecfbf2fe