Výsledky vyhledávání - "Esther J Cooke"

Defective TAFI activation in hemophilia A mice is a major contributor to joint bleeding

Autor: Niels Behrendt, Laurent O. Mosnier, Esther J Cooke, Annette von Drygalski, Paul Declerck, Tine Wyseure, Joost C. M. Meijers

Publikováno v: Wyseure, T, Cooke, E J, Declerck, P J, Behrendt, N, Meijers, J C M, Von Drygalski, A & Mosnier, L O 2018, ' Defective TAFI activation in hemophilia a mice is a major contributor to joint bleeding ', Blood, vol. 132, no. 15, pp. 1593-1603 . https://doi.org/10.1182/blood-2018-01-828434
Blood, 132(15), 1593-1603. American Society of Hematology

Joint bleeds are common in congenital hemophilia but rare in acquired hemophilia A (aHA) for reasons unknown. To identify key mechanisms responsible for joint-specific bleeding in congenital hemophilia, bleeding phenotypes after joint injury and tail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627dde41492b27e85fd2d2867cc7facb
https://doi.org/10.1182/blood-2018-01-828434

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Gene Expression after Hemarthrosis Differs between FVIII-Deficient Mice Treated with Recombinant FVIII or FVIII-Fc Fusion Protein

Autor: Samantha Ruiz, Esther J Cooke, Annette von Drygalski, Jenny Y Zhou, Bilgimol Chumappumkal Joseph, Sonha Nguyen

Publikováno v: Blood. 138:3175-3175

Introduction Local and systemic molecular responses to hemarthroses in hemophilia are not well understood. Emerging clinical evidence suggests that treatment with FVIII-Fc Fusion protein (FcFVIII), using the Fc-portion of immunoglobulin for half-life

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::461de036bb1d1a9cff08815d42ad723a
https://doi.org/10.1182/blood-2021-149923

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TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding

Autor: John Morser, Merissa Olmer, Bettina Wanko, Yosuke Morodomi, Martin Lotz, Jenny Y Zhou, Ruchi Agashe, Tingyi Yang, Annette von Drygalski, Laurent O. Mosnier, Tine Wyseure, Niels Behrendt, Esther J Cooke

Publikováno v: Wyseure, T, Yang, T, Zhou, J Y, Cooke, E J, Wanko, B, Olmer, M, Agashe, R, Morodomi, Y, Behrendt, N, Lotz, M, Morser, J, von Drygalski, A & Mosnier, L O 2019, ' TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding ', JCI Insight, vol. 4, no. 19, e128379, pp. 1-19 . https://doi.org/10.1172/jci.insight.128379

Excessive vascular remodeling is characteristic of hemophilic arthropathy (HA) and may contribute to joint bleeding and the progression of HA. Mechanisms for pathological vascular remodeling after hemophilic joint bleeding are unknown. In hemophilia,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb10a836c1f60300f560639f8266238d
https://doi.org/10.1172/jci.insight.128379

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Efficacy and safety of point-of-care ultrasound-guided intra-articular corticosteroid joint injections in patients with haemophilic arthropathy

Autor: S. Holle, Richard F. W. Barnes, Randy E. Moore, A Ceponis, A. von Drygalski, Colleen M. Moran, Tudor H. Hughes, Esther J Cooke, E. J. Martin

Publikováno v: Haemophilia. 23:135-143

Introduction and Objectives Intra-articular corticosteroid injections are standard of care for managing joint pain secondary to osteoarthritis or rheumatoid arthritis but are rarely used in haemophilic arthropathy. We have introduced and evaluated th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f10fe44c873506a3c958b4e19fe7d92
https://doi.org/10.1111/hae.13057

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Lymphatic Remodeling Associated with Hemophilic Joint Bleeding in FVIII-Deficient Mice

Autor: Chanond A Nasamran, Kathleen M. Fisch, Esther J Cooke, Annette von Drygalski

Publikováno v: Blood. 136:20-20

Introduction Hemophilic joint bleeding leads to toxic synovial iron accumulation, contributing to synovitis. Mechanisms of blood and iron clearance from the joint remain largely unknown. This study aimed to explore synovial lymphatic vessel remodelin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea1e0f4947b7ba178fa86317e9e6d209
https://doi.org/10.1182/blood-2020-143369

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Vascular Permeability and Remodelling Coincide with Inflammatory and Reparative Processes after Joint Bleeding in Factor VIII-Deficient Mice

Autor: Shweta Joshi, Vikas Bhat, Annette von Drygalski, Esther J Cooke, Laurent O. Mosnier, Jenny Y Zhou, Donald L. Durden, Tine Wyseure

Publikováno v: Thrombosis and haemostasis. 118(6)

Vascular remodelling is a prominent feature of haemophilic arthropathy (HA) that may underlie re-bleeding, yet the nature of vascular changes and underlying mechanisms remain largely unknown. Here, we aimed to characterize synovial vascular remodelli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4cd0a504193b80a6a7a65c8ac7d6463
https://pubmed.ncbi.nlm.nih.gov/30071568

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Mechanisms of Iron Clearance from the Joint in FVIII-Deficient Mice after Induced Hemarthrosis

Autor: Kathleen M. Fisch, Chanond A Nasamran, Esther J Cooke, Annette von Drygalski

Publikováno v: Blood. 134:157-157

Introduction Hemarthrosis in hemophilia causes toxic iron accumulation in the joint, which contributes to synovitis. This study aimed to explore mechanisms and timing of iron clearance from the joint space in mouse models of induced hemarthrosis. Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c714552a07ee33516a4b022e8693bb2a
https://doi.org/10.1182/blood-2019-131576

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