Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis

Autor: Oliver Waidmann, Thomas Pleli, Andreas Weigert, Esther Imelmann, Bianca Kakoschky, Christian Schmithals, Claudia Döring, Matthias Frank, Thomas Longerich, Verena Köberle, Martin-Leo Hansmann, Bernhard Brüne, Stefan Zeuzem, Albrecht Piiper, Ivan Dikic

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)

Abstract The nuclear factor kappa beta (NFκB) signaling pathway plays an important role in liver homeostasis and cancer development. Tax1-binding protein 1 (Tax1BP1) is a regulator of the NFκB signaling pathway, but its role in the liver and hepato

Externí odkaz: https://doaj.org/article/740d319af09b47b9b936f1021dead416

miRNA miR-21 Is Largely Dispensable for Intrathymic T-Cell Development

Autor: Heike Kunze-Schumacher, Samantha J. Winter, Esther Imelmann, Andreas Krueger

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Development of T cells in the thymus is tightly controlled to continually produce functional, but not autoreactive, T cells. miRNAs provide a layer of post-transcriptional gene regulation to this process, but the role of many individual miRNAs in T-c

Externí odkaz: https://doaj.org/article/e18e993922404b7b9078731e841e81fe

MicroRNA miR-181a/b-1 controls MAIT cell development

Autor: Esther Imelmann, Heike Kunze-Schumacher, Zoe Grewers, Samantha J. Winter, Tabea Osthues, Andreas Krueger

Publikováno v: Immunology and Cell Biology. 97:190-202

Mucosal-associated invariant T (MAIT) cells constitute a major fraction of innate-like T cells in humans with critical roles in defense against microbial pathogens and in maintaining mucosal integrity. However, the molecular mechanisms underlying MAI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048f51ca057b3d6140968d2ff63087b1
https://doi.org/10.1111/imcb.12211

miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity

Autor: Jonas Blume, Lisa Föhse, Solaiman Raha, Siegfried Weiss, Andreas Krueger, Rebecca J. Brownlie, Rose Zamoyska, Esther Imelmann, Samantha J. Winter, Takashi Sekiya, Jochen T. Frueh, Nikita A. Verheyden, Heike Kunze-Schumacher, Akihiko Yoshimura, Maximiliano G. Gutierrez, Evelyn Ullrich, Jochen Huehn, Immo Prinz, Marcin Łyszkiewicz, Katrin Witzlau, Natalia Ziętara, Jacek Puchałka

Publikováno v: PLoS Biology
PLoS Biology, Vol 17, Iss 3, p e2006716 (2019)
PLoS biology
Łyszkiewicz, M, Winter, S J, Witzlau, K, Föhse, L, Brownlie, R, Puchałka, J, Verheyden, N A, Kunze-Schumacher, H, Imelmann, E, Blume, J, Raha, S, Sekiya, T, Yoshimura, A, Frueh, J T, Ullrich, E, Huehn, J, Weiss, S, Gutierrez, M G, Prinz, I, Zamoyska, R, Ziętara, N & Krueger, A 2019, ' mir-181A/B-1 controls thymic selection of treg cells and tunes their suppressive capacity ', PLoS Biology, vol. 17, no. 3, e2006716 . https://doi.org/10.1371/journal.pbio.2006716

The interdependence of selective cues during development of regulatory T cells (Treg cells) in the thymus and their suppressive function remains incompletely understood. Here, we analyzed this interdependence by taking advantage of highly dynamic cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a74bb7ab18b85d54babb5a692ae0ff2
https://doi.org/10.1371/journal.pbio.2006716