Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Esther Hoste"'
Autor:
Karel F. A. Van Damme, Pieter Hertens, Arne Martens, Elisabeth Gilis, Dario Priem, Inge Bruggeman, Amelie Fossoul, Jozefien Declercq, Helena Aegerter, Andy Wullaert, Tino Hochepied, Esther Hoste, Lieselotte Vande Walle, Mohamed Lamkanfi, Savvas N. Savvides, Dirk Elewaut, Bart N. Lambrecht, Geert van Loo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract A20 serves as a critical brake on NF-κB-dependent inflammation. In humans, polymorphisms in or near the TNFAIP3/A20 gene have been linked to various inflammatory disorders, including systemic lupus erythematosus (SLE) and rheumatoid arthrit
Externí odkaz:
https://doaj.org/article/0bf2e4c99bae45e2afbc4924a4035aa2
Autor:
Sahana Srinivasan, Daliya Kancheva, Sofie De Ren, Takashi Saito, Maude Jans, Fleur Boone, Charysse Vandendriessche, Ine Paesmans, Hervé Maurin, Roosmarijn E. Vandenbroucke, Esther Hoste, Sofie Voet, Isabelle Scheyltjens, Benjamin Pavie, Saskia Lippens, Marius Schwabenland, Marco Prinz, Takaomi Saido, Astrid Bottelbergs, Kiavash Movahedi, Mohamed Lamkanfi, Geert van Loo
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundAlzheimer’s disease (AD) is the most common neurodegenerative disorder affecting memory and cognition. The disease is accompanied by an abnormal deposition of ß-amyloid plaques in the brain that contributes to neurodegeneration and is kn
Externí odkaz:
https://doaj.org/article/9176fde1a9644a96960b77fefeca6640
Autor:
Esther Hoste, Kim Lecomte, Karl Annusver, Niels Vandamme, Jana Roels, Sophia Maschalidi, Lien Verboom, Hanna-Kaisa Vikkula, Mozes Sze, Lisette Van Hove, Kevin Verstaen, Arne Martens, Tino Hochepied, Yvan Saeys, Kodi Ravichandran, Maria Kasper, Geert van Loo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
OTULIN is a deubiquitinase for linear ubiquitin chains. Here the authors show, using genetic mouse models and single-cell RNA-sequencing, that deficiency of OTULIN in keratinocytes causes skin inflammation and verrucous carcinoma via the induction of
Externí odkaz:
https://doaj.org/article/8b051a56d99b49d783afe85a0b01f20a
Autor:
Maarten A. Mees, Fleur Boone, Thomas Bouwen, Frederik Vanaerschot, Charlotte Titeca, Hanna-Kaisa Vikkula, Leen Catrysse, Anja Vananroye, Erin Koos, Stelios Alexandris, Sabine Rosenfeldt, Samuel Eyley, Joachim Koetz, Geert van Loo, Wim Thielemans, Esther Hoste
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 27 (2022)
Efficient wound repair is crucial for mammalian survival. Healing of skin wounds is severely hampered in diabetic patients, resulting in chronic non-healing wounds that are difficult to treat. High-mobility group box 1 (HMGB1) is an important signali
Externí odkaz:
https://doaj.org/article/38dc3810a7fd4ddaa23ec3da5826d916
Autor:
Leen Catrysse, Bastiaan Maes, Parul Mehrotra, Arne Martens, Esther Hoste, Liesbet Martens, Christian Maueröder, Anneleen Remmerie, Anna Bujko, Karolina Slowicka, Mozes Sze, Hanna Vikkula, Bart Ghesquière, Charlotte L. Scott, Yvan Saeys, Bart van de Sluis, Kodi Ravichandran, Sophie Janssens, Geert van Loo
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109748- (2021)
Summary: Obesity-induced inflammation is a major driving force in the development of insulin resistance, type 2 diabetes (T2D), and related metabolic disorders. During obesity, macrophages accumulate in the visceral adipose tissue, creating a low-gra
Externí odkaz:
https://doaj.org/article/8fd7d230be304c529b1a2ae294191f7d
Autor:
Lien Verboom, Arne Martens, Dario Priem, Esther Hoste, Mozes Sze, Hanna Vikkula, Lisette Van Hove, Sofie Voet, Jana Roels, Jonathan Maelfait, Laura Bongiovanni, Alain de Bruin, Charlotte L. Scott, Yvan Saeys, Manolis Pasparakis, Mathieu J.M. Bertrand, Geert van Loo
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2237-2247.e6 (2020)
Summary: Inflammatory signaling pathways are tightly regulated to avoid chronic inflammation and the development of disease. OTULIN is a deubiquitinating enzyme that controls inflammation by cleaving linear ubiquitin chains generated by the linear ub
Externí odkaz:
https://doaj.org/article/1511e219df8c4f228d716b7cc3be84c8
Autor:
Tamara Muliaditan, Jonathan Caron, Mary Okesola, James W. Opzoomer, Paris Kosti, Mirella Georgouli, Peter Gordon, Sharanpreet Lall, Desislava M. Kuzeva, Luisa Pedro, Jacqueline D. Shields, Cheryl E. Gillett, Sandra S. Diebold, Victoria Sanz-Moreno, Tony Ng, Esther Hoste, James N. Arnold
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The relationship between wound healing and cancer is intricate and complex. Here, the authors show that in breast cancer models an IL-6 driven co-expression of FAP and HO-1 in tumour-associated macrophages, similar to the wound healing response, faci
Externí odkaz:
https://doaj.org/article/8c66af37aaba412f826bf1e4aabd5fd7
Autor:
Sofie Voet, Conor Mc Guire, Nora Hagemeyer, Arne Martens, Anna Schroeder, Peter Wieghofer, Carmen Daems, Ori Staszewski, Lieselotte Vande Walle, Marta Joana Costa Jordao, Mozes Sze, Hanna-Kaisa Vikkula, Delphine Demeestere, Griet Van Imschoot, Charlotte L. Scott, Esther Hoste, Amanda Gonçalves, Martin Guilliams, Saskia Lippens, Claude Libert, Roos E. Vandenbroucke, Ki-Wook Kim, Steffen Jung, Zsuzsanna Callaerts-Vegh, Patrick Callaerts, Joris de Wit, Mohamed Lamkanfi, Marco Prinz, Geert van Loo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
As resident macrophages of the brain, microglia are important for neuroinflammatory responses. This work shows that nuclear factor kappa B regulatory protein A20 is important for microglia activation and regulation during inflammation of the central
Externí odkaz:
https://doaj.org/article/3142b0c70aa74f90b3c6f5b5f17ce066
Autor:
Esther Hoste, Christian Maueröder, Lisette van Hove, Leen Catrysse, Hanna-Kaisa Vikkula, Mozes Sze, Bastiaan Maes, Dyah Karjosukarso, Liesbet Martens, Amanda Gonçalves, Eef Parthoens, Ria Roelandt, Wim Declercq, Ignacia Fuentes, Francis Palisson, Sergio Gonzalez, Julio C. Salas-Alanis, Louis Boon, Peter Huebener, Klaas Willem Mulder, Kodi Ravichandran, Yvan Saeys, Robert Felix Schwabe, Geert van Loo
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2689-2701.e4 (2019)
Summary: Regenerative responses predispose tissues to tumor formation by largely unknown mechanisms. High-mobility group box 1 (HMGB1) is a danger-associated molecular pattern contributing to inflammatory pathologies. We show that HMGB1 derived from
Externí odkaz:
https://doaj.org/article/7a64937c6b7147c69bf52d9db0900e4f
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
In the last few decades, our understanding of Langerhans cells (LCs) has drastically changed based on novel findings regarding the developmental origin and biological functions of these epidermis-specific resident immune cells. It has become clear th
Externí odkaz:
https://doaj.org/article/b966738b0918414a9b965134d9ca545b