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Akademický článek

Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells

Autor: Bahar Mirshekar-Syahkal, Esther Haak, Gillian M. Kimber, Kevin van Leusden, Kirsty Harvey, John O'Rourke, Jorge Laborda, Steven R. Bauer, Marella F. T. R. de Bruijn, Anne C. Ferguson-Smith, Elaine Dzierzak, Katrin Ottersbach

Publikováno v: Haematologica, Vol 98, Iss 2 (2013)

The first mouse adult-repopulating hematopoietic stem cells emerge in the aorta-gonad-mesonephros region at embryonic day (E) 10.5. Their numbers in this region increase thereafter and begin to decline at E12.5, thus pointing to the possible existenc

Externí odkaz: https://doaj.org/article/0e2e28f91c7d4a36b92c84d783536705

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Akademický článek

Interleukin-1 regulates hematopoietic progenitor and stem cells in the midgestation mouse fetal liver

Autor: Claudia Orelio, Marian Peeters, Esther Haak, Karin van der Horn, Elaine Dzierzak

Publikováno v: Haematologica, Vol 94, Iss 4 (2009)

Background Hematopoietic progenitors are generated in the yolk sac and aorta-gonad-mesonephros region during early mouse development. At embryonic day 10.5 the first hematopoietic stem cells emerge in the aorta-gonad-mesonephros. Subsequently, hemato

Externí odkaz: https://doaj.org/article/fb0c917c44d74675a688f93c64b277f1

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TGF-beta 2 is involved in the preservation of the chondrocyte phenotype under hypoxic conditions

Autor: Ruud Das, Esther Haak, Holger Jahr, U.T. Timur, Harrie Weinans, S. Edip, Christoph Jan Wruck

Publikováno v: Annals of Anatomy, 198, 1. Urban und Fischer Verlag Jena
Annals of Anatomy-Anatomischer Anzeiger, 198, 1-10. Elsevier GmbH

Culturing chondrocytes under oxygen tension closely resembling their in vivo environment has been shown to have positive effects on matrix synthesis. In redifferentiation of expanded chondrocytes, hypoxia increased collagen type II expression. Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3773ed6beef2e389685bc1ffda2a48da
https://doi.org/10.1016/j.aanat.2014.11.003

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Inhibiting calcineurin activity under physiologic tonicity elevates anabolic but suppresses catabolic chondrocyte markers

Autor: Nicole Kops, Esther Haak, Holger Jahr, Anna E. van der Windt, Harrie Weinans, Jan A N Verhaar

Publikováno v: Arthritis & Rheumatism, 64(6), 1929-1939. John Wiley & Sons Ltd.

Objective The physiologic interstitial tonicity of healthy articular cartilage (350480 mOsm) is lowered to 280350 mOsm in osteoarthritis (OA). This results in loss of tissue prestress, altered compressive behavior, and, thus, inferior tissue properti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc6471ccdf91c77c8f7d29fa21eb6a7
https://doi.org/10.1002/art.34369

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Human Placenta Is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells throughout Development

Autor: Ivoune Lauw, Mihaela Crisan, Sandra Mendes, Manfred Kayser, Tom Cupedo, Karine Bollerot, Monique M.A. Verstegen, Natalie Papazian, Eric A.P. Steegers, Parisa Imanirad, Mark Vermeulen, Francesco Cerisoli, Esther Haak, Catherine Robin, Reinier van der Linden, Polynikis Kaimakis, Ruud Jorna, Humaira Nawaz-Yousaf, Elaine Dzierzak

Publikováno v: Cell Stem Cell, 5(4), 385-395. Cell Press

SummaryHematopoietic stem cells (HSCs) are responsible for the life-long production of the blood system and are pivotal cells in hematologic transplantation therapies. During mouse and human development, the first HSCs are produced in the aorta-gonad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dccbb2f23c3aeb2bda8918f7dbbbb7f
https://hdl.handle.net/1765/17228

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Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo

Autor: Esther Haak, Marian Peeters, Elaine Dzierzak, Claudia Orelio

Publikováno v: Blood, 112(13), 4895-4904. American Society of Hematology

Hematopoiesis during development is a dynamic process, with many factors involved in the emergence and regulation of hematopoietic stem cells (HSCs) and progenitor cells. Whereas previous studies have focused on developmental signaling and transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a89c0dc936d41553202a10835d94fda
https://hdl.handle.net/1765/28793

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Maternal retinoids control innate lymphoid cells and set the immune fitness of the progeny

Publikováno v: Nature (in press).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=erc_________::864d60386c8f32780eecd56f6e704f06

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Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

Publikováno v: Nature
van de Pavert, S A, Ferreira, M, Domingues, R G, Ribeiro, H, Molenaar, R, Moreira-Santos, L, Almeida, F F, Ibiza, S, Barbosa, I, Goverse, G, Labao-Almeida, C, Godinho-Silva, C, Konijn, T, Schooneman, D, O'Toole, T G, Mizee, M R, Habani, Y, Haak, E, Santori, F R, Littman, D R, Schulte-Merker, S, Dzierzak, E, Simas, J P, Mebius, R E & Veiga-Fernandes, H 2014, ' Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity ', Nature, vol. 508, no. 7494, pp. 123-127 . https://doi.org/10.1038/nature13158
ResearcherID
Nature, 508(7494), 123-+. Nature Publishing Group
Nature, 508(7494), 123-7. Nature Publishing Group
Nature, 508(7494), 123-127. Nature Publishing Group

The impact of nutritional status during fetal life on the overall health of adults has been recognized(1); however, dietary effects on the developing immune system are largely unknown. Development of secondary lymphoid organs occurs during embryogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce7050a044ed4e059bf1076dbaeb067f

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