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pro vyhledávání: '"Esther Giesselmann"'
Publikováno v:
Microbial Cell Factories, Vol 16, Iss 1, Pp 1-9 (2017)
Abstract Background Virus infected killer strains of the baker’s yeast Saccharomyces cerevisiae secrete protein toxins such as K28, K1, K2 and Klus which are lethal to sensitive yeast strains of the same or related species. K28 is somewhat unique a
Externí odkaz:
https://doaj.org/article/338e3ab9c3dc439bb9893bca6c26fa02
Publikováno v:
Microbial Cell Factories, Vol 16, Iss 1, Pp 1-9 (2017)
Microbial Cell Factories
Microbial Cell Factories
Background Virus infected killer strains of the baker’s yeast Saccharomyces cerevisiae secrete protein toxins such as K28, K1, K2 and Klus which are lethal to sensitive yeast strains of the same or related species. K28 is somewhat unique as it repr
Autor:
Domenik Rammo, Emilia Tschacksch, Manfred J. Schmitt, Jenny Spindler, Jens Rettig, Miriam Steimer, Ute Becherer, Julia Dausend, Andrea Blum, Nina C. Müller, Frank Breinig, Esther Gießelmann, Björn Becker
Publikováno v:
Scientific Reports
A/B toxins such as cholera toxin, Pseudomonas exotoxin and killer toxin K28 contain a KDEL-like amino acid motif at one of their subunits which ensures retrograde toxin transport through the secretory pathway of a target cell. As key step in host cel
Autor:
Esther Gießelmann, Susheela Carroll, Manfred J. Schmitt, David G. Drubin, Helen E. M. Stimpson, Peter C. Stirling
Publikováno v:
Developmental Cell. (4):552-560
SummaryLike Ricin, Shiga, and Cholera toxins, yeast K28 is an A/B toxin that depends on endocytosis and retrograde trafficking for toxicity. Knowledge of the specific proteins, lipids, and mechanisms required for trafficking and killing by these toxi