Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Esther E. Widgren"'
Autor:
Michael G. O'Rand, Richard T. Richardson, Esther E. Widgren, Erick J. R. Silva, Katherine G. Hamil
Publikováno v:
Journal of Andrology. 32:698-704
The Laboratories for Reproductive Biology at the University of North Carolina at Chapel Hill began collaboration with Human Genome Sciences (Rockville, Maryland) to sequence a human epididymal library and identify epididymal-specific genes. Among the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7126bfba8cf4293430beb752e2d9a5
https://doi.org/10.2164/jandrol.110.012781
https://doi.org/10.2164/jandrol.110.012781
Publikováno v:
Biology of Reproduction. 80:279-285
Epididymal protease inhibitor (eppin [official symbol, SPINLW1]) is of interest as a male contraceptive target because of its specificity and location on the human sperm surface. We have examined the effect of anti-eppin antibodies from infertile mal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c337c7fc2c456633011ae31ef88fbc5a
https://doi.org/10.1095/biolreprod.108.072942
https://doi.org/10.1095/biolreprod.108.072942
Publikováno v:
Biology of Reproduction. 77:476-484
Eppin (SPINLW1; serine peptidase inhibitor-like with Kunitz and WAP domains 1 (eppin); epididymal protease inhibitor) coats the surface of human ejaculate spermatozoa and originates from Sertoli and epididymal epithelial cells. In this study, we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ac30081fbd74569b6a47d7b93136b20
https://doi.org/10.1095/biolreprod.107.060194
https://doi.org/10.1095/biolreprod.107.060194
Autor:
Michael G. O'Rand, William F. Marzluff, Eric J. Wagner, Gail Grossman, Oleg M. Alekseev, Kelly D. Sullivan, Randy J. Thresher, Esther E. Widgren, Richard T. Richardson
Publikováno v:
Journal of Biological Chemistry. 281:21526-21534
A multichaperone nucleosome-remodeling complex that contains the H1 linker histone chaperone nuclear autoantigenic sperm protein (NASP) has recently been described. Linker histones (H1) are required for the proper completion of normal development, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19b533d7627895a2c8256a18cdf8671
https://doi.org/10.1074/jbc.m603816200
https://doi.org/10.1074/jbc.m603816200
Autor:
Perumal Sivashanmugam, Michael G. O'Rand, Richard T. Richardson, Zengjun Wang, Esther E. Widgren
Publikováno v:
Biology of Reproduction. 72:1064-1070
Eppin (SPINLW1; GeneID, 57119) is a single-copy gene encoding a cysteine-rich protein found only in the testis and epididymis, which contains both Kunitz-type and WAP-type four disulfide core protease inhibitor consensus sequences. This study demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd9e019bc3b607ab520daf3902800390
https://doi.org/10.1095/biolreprod.104.036483
https://doi.org/10.1095/biolreprod.104.036483
Publikováno v:
Journal of Biological Chemistry. 280:2904-2911
NASP (nuclear autoantigenic sperm protein) is a linker histone-binding protein found in all dividing cells that is regulated by the cell cycle (Richardson, R. T., Batova, I. N., Widgren, E. E., Zheng, L. X., Whitfield, M., Marzluff, W. F., and O'Rand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::949d7a56a55c2eb9d20e098f79bb297d
https://doi.org/10.1074/jbc.m410397200
https://doi.org/10.1074/jbc.m410397200
Autor:
Oleg M. Alekseev, Michael G. O'Rand, Richard T. Richardson, Esther E. Widgren, David C. Bencic
Publikováno v:
Journal of Biological Chemistry. 278:8846-8852
NASP is an H1 histone-binding protein that is cell cycle-regulated and occurs in two major forms: tNASP, found in gametes, embryonic cells, and transformed cells; and sNASP, found in all rapidly dividing somatic cells (Richardson, R. T., Batova, I. N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6b3858c34e25fc3a41d81fbbcfbd25
https://doi.org/10.1074/jbc.m210352200
https://doi.org/10.1074/jbc.m210352200
Publikováno v:
Clinical and Experimental Immunology. 121:201-209
SUMMARYThe human nuclear autoantigenic sperm protein, NASP, is a testicular histone-binding protein of 787 amino acids to which most vasectomized men develop autoantibodies. In this study to define the boundaries of antigenic regions and epitope reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b395cb5545768f77890c8d82d587a4
https://doi.org/10.1046/j.1365-2249.2000.01303.x
https://doi.org/10.1046/j.1365-2249.2000.01303.x
Autor:
Esther E. Widgren, Isabel A. Lea, Ying Wen, M. J. C. van Lierop, A.J. Grootenhuis, M. van Duin, Michael G. O'Rand
Publikováno v:
Biology of Reproduction. 59:527-536
The development of a contraceptive vaccine based on a gamete-specific antigen requires knowledge of the ability of the antigen to elicit an immune response that inhibits fertilization. A well-defined immune response, as elicited by a synthetic peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc15fc496e0ecdec24c0f5139a1148f4
https://doi.org/10.1095/biolreprod59.3.527
https://doi.org/10.1095/biolreprod59.3.527
Publikováno v:
Molecular Reproduction and Development. 47:66-71
In this study, cDNAs encoding the sperm protein Sp17 from the baboon (Papio papio) have been cloned and sequenced. Three clones, differing in the lengths of their 3' untranslated regions, were identified, which were encoded by mRNA transcripts of 0.8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7963e31b75dd058089a08f4b7686d3b
https://doi.org/10.1002/(sici)1098-2795(199705)47:1<66::aid-mrd9>3.0.co
https://doi.org/10.1002/(sici)1098-2795(199705)47:1<66::aid-mrd9>3.0.co