Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Esther D. Mwaikambo"'
Autor:
Margaret A. Bush, Nicholas M. Anstey, Tsin W. Yeo, Salvatore M. Florence, Donald L. Granger, Esther D. Mwaikambo, J. Brice Weinberg
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Malaria caused by Plasmodium falciparum results in over 400,000 deaths annually, predominantly affecting African children. In addition, non-falciparum species including vivax and knowlesi cause significant morbidity and mortality. Vascular dysfunctio
Externí odkaz:
https://doaj.org/article/d8865b54113f4dfbab7a7afae15c7a09
Autor:
Matthew P Rubach, Jackson Mukemba, Salvatore Florence, Bert K Lopansri, Keith Hyland, Alicia D Volkheimer, Tsin W Yeo, Nicholas M Anstey, J Brice Weinberg, Esther D Mwaikambo, Donald L Granger
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004655 (2015)
Decreased bioavailability of nitric oxide (NO) is a major contributor to the pathophysiology of severe falciparum malaria. Tetrahydrobiopterin (BH4) is an enzyme cofactor required for NO synthesis from L-arginine. We hypothesized that systemic levels
Externí odkaz:
https://doaj.org/article/918548f14c464ea3bdd6804157ac1eb8
Autor:
Matthew P. Rubach, Donald L. Granger, Esther D. Mwaikambo, Margaret A. Bush, Nicholas M. Anstey, Tsin W. Yeo, Youwei Chen, Salvatore M. Florence, J B Weinberg, Ayam R. Kalingonji
Publikováno v:
FASEB J
A layer of glycocalyx covers the vascular endothelium serving important protective and homeostatic functions. The objective of this study was to determine if breakdown of the endothelial glycocalyx (eGC) occurs during malaria infection in children. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92bb26322e8749a148602ab0270508eb
https://doi.org/10.1096/fj.202100277rr
https://doi.org/10.1096/fj.202100277rr
Autor:
Peggy A. Bush, Sarah P. Young, Nicholas M. Anstey, Tsin W. Yeo, Esther D. Mwaikambo, Haoyue Zhang, Youwei Chen, David S. Millington, J. Brice Weinberg, Donald L. Granger
Publikováno v:
FASEB J
Cerebral malaria (CM) from Plasmodium falciparum infection is associated with endothelial dysfunction and parasite sequestration. The glycocalyx (GCX), a carbohydrate-rich layer lining the endothelium, is crucial in vascular homeostasis. To evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234d7e81ec40237aec5228405dc3e5ae
https://doi.org/10.1096/fj.201901048rr
https://doi.org/10.1096/fj.201901048rr
Autor:
Sara Nakielny, Ryan A. Simmons, Nicholas M. Anstey, Charles Langelier, Bert K. Lopansri, Jackson Mukemba, Salvatore M. Florence, Matthew P. Rubach, Keith Hyland, Esther D. Mwaikambo, Donald L. Granger, J. Brice Weinberg, Tsin W. Yeo, Joseph L. DeRisi
Publikováno v:
J Infect Dis
Background Cerebral malaria (CM) pathogenesis remains incompletely understood. Having shown low systemic levels of tetrahydrobiopterin (BH4), an enzymatic cofactor for neurotransmitter synthesis, we hypothesized that BH4 and BH4-dependent neurotransm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d797aa106305e7098ad1b0e80ae6378
https://pubmed.ncbi.nlm.nih.gov/33617646
https://pubmed.ncbi.nlm.nih.gov/33617646
Autor:
Matthew P Rubach, Jackson Mukemba, Salvatore Florence, Bernard John, Benjamin Crookston, Bert K Lopansri, Tsin W Yeo, Kim A Piera, Stephen C Alder, J Brice Weinberg, Nicholas M Anstey, Donald L Granger, Esther D Mwaikambo
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e35985 (2012)
Plasma Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) concentrations, a measure of parasite biomass, have been correlated with malaria severity in adults, but not yet in children. We measured plasma PfHRP-2 in Tanzanian children with uncomp
Externí odkaz:
https://doaj.org/article/8be4adef935346b39b6e2560fe91cb7c
Autor:
Salvatore M. Florence, Nicholas M. Anstey, Matthew P. Rubach, Ayam R. Kalingonji, Haoyue Zhang, Bert K. Lopansri, J. Will Thompson, Tsin W. Yeo, Sarah P. Young, Jackson Mukemba, Donald L. Granger, Esther D. Mwaikambo, David S. Millington, J. Brice Weinberg
The low bioavailability of nitric oxide (NO) and its precursor, arginine, contributes to the microvascular pathophysiology of severe falciparum malaria. To better characterize the mechanisms underlying hypoargininemia in severe malaria, we measured t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb391775a43971ea903ce62bcbd8db67
https://hdl.handle.net/10356/85330
https://hdl.handle.net/10356/85330
Autor:
J. Brice Weinberg, Matthew P. Rubach, Salvatore M. Florence, Youwei Chen, Donald L. Granger, Nicholas M. Anstey, Ayam R. Kalingonji, Tsin W. Yeo, Margaret A. Bush, Esther D. Mwaikambo
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::616afb71cf6a18b89c1f92a49b3f329c
https://doi.org/10.1096/fasebj.2020.34.s1.09367
https://doi.org/10.1096/fasebj.2020.34.s1.09367
Autor:
Youwei Chen, Ayam R. Kalingonji, Esther D. Mwaikambo, Donald L. Granger, Tsin W. Yeo, J. Brice Weinberg, Salvatore M. Florence, Nicholas M. Anstey
Publikováno v:
Open Forum Infectious Diseases
Microvascular function and oxygen consumption affect oxygen homeostasis but have not been assessed in African children with malaria. Microvascular function in Tanzanian children with severe malaria (SM) or uncomplicated malaria were 39% and 72%, resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8da5e805c245b608c5cff34406ac02
https://pubmed.ncbi.nlm.nih.gov/28852670
https://pubmed.ncbi.nlm.nih.gov/28852670
Autor:
Esther D. Mwaikambo, Donald L. Granger, David J. Sullivan, Jackson Mukemba, Salvatore M. Florence, Kim A. Piera, Nicholas M. Anstey, Kiran T. Thakur, J. Brice Weinberg, Carlos A. Pardo, Kei Mikita
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 91:486-492
A cerebrospinal fluid (CSF) biomarker for cerebral malaria (CM) has not been validated. We examined the detection, semiquantification, and clinical use of the Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) as a parasite antigen biomarker fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06fa0c844740f4653d5b43980e9c74f
https://doi.org/10.4269/ajtmh.14-0210
https://doi.org/10.4269/ajtmh.14-0210