Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Esther Castellano"'
Autor:
Fernando C. Baltanás, Rósula García-Navas, Pablo Rodríguez-Ramos, Nuria Calzada, Cristina Cuesta, Javier Borrajo, Rocío Fuentes-Mateos, Andrea Olarte-San Juan, Nerea Vidaña, Esther Castellano, Eugenio Santos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The impact of genetic ablation of SOS1 or SOS2 is evaluated in a murine model of KRASG12D-driven lung adenocarcinoma (LUAD). SOS2 ablation shows some protection during early stages but only SOS1 ablation causes significant, specific long ter
Externí odkaz:
https://doaj.org/article/5990be63516441ab98c1c249dd88b37d
Autor:
Esther Castellano, Miriam Molina-Arcas, Agata Adelajda Krygowska, Philip East, Patricia Warne, Alastair Nicol, Julian Downward
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Ras signalling through PI3K kinase has an important role in tumour initiation and progression. Here, the authors show that the interaction of Ras with PI3-Kinase p110α and the subsequent activation of Rac-GTPase impairs cell -cell interaction by blo
Externí odkaz:
https://doaj.org/article/2bae102d12544abe85cdc59962e710f8
Publikováno v:
Genes
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Genes, Vol 12, Iss 819, p 819 (2021)
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Genes, Vol 12, Iss 819, p 819 (2021)
© 2021 by the authors.
Ras and Rho proteins are GTP-regulated molecular switches that control multiple signaling pathways in eukaryotic cells. Ras was among the first identified oncogenes, and it appears mutated in many forms of human cancer. I
Ras and Rho proteins are GTP-regulated molecular switches that control multiple signaling pathways in eukaryotic cells. Ras was among the first identified oncogenes, and it appears mutated in many forms of human cancer. I
Publikováno v:
Genes, Vol 12, Iss 1094, p 1094 (2021)
Genes
Genes
© 2021 by the authors
Ras proteins are essential mediators of a multitude of cellular processes, and its deregulation is frequently associated with cancer appearance, progression, and metastasis. Ras-driven cancers are usually aggressive and di
Ras proteins are essential mediators of a multitude of cellular processes, and its deregulation is frequently associated with cancer appearance, progression, and metastasis. Ras-driven cancers are usually aggressive and di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63572d69dccf73a9b7cf3ecd76675bb7
http://hdl.handle.net/10261/262272
http://hdl.handle.net/10261/262272
Autor:
Laura Otero-García, Eva Durán-Martín, Esther Castellanos-Torres, Belén Sanz-Barbero, Carmen Vives-Cases
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0297886 (2024)
IntroductionIntimate partner violence (IPV) is common among young people, but the use of IPV resources among young adult women and teenagers is limited. This study aims to analyze professionals' perceptions about the main barriers and facilitators en
Externí odkaz:
https://doaj.org/article/64b38bd6ee0b4a08bd130f480669a9da
Publikováno v:
Gaceta Sanitaria, Vol 38, Iss , Pp 102371- (2024)
Resumen: Objetivo: Analizar las percepciones y experiencias de la población joven en España sobre la violencia sexual (VS), sus posibles causas, víctimas y perpetradores. Método: Estudio cualitativo basado en entrevistas semiestructuradas a 22 j
Externí odkaz:
https://doaj.org/article/9cae0a64dfa942258e4e67c51a65c382
Autor:
Julian Downward, Patricia H. Warne, Agata Adelajda Krygowska, Miriam Molina-Arcas, Alastair Nicol, Esther Castellano, Philip East
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications
RAS signalling through phosphoinositide 3-kinase (PI3-Kinase) has been shown to have an essential role in tumour initiation and maintenance. RAS also regulates cell motility and tumour invasiveness, but the role of direct RAS binding to PI3-Kinase in
Autor:
Gordon Stamp, Santiago Zelenay, Miguel M. Murillo, Julian Downward, Francois Lassailly, Emma Nye, Esther Castellano
Publikováno v:
Journal of Clinical Investigation. 124:3601-3611
Direct interaction of RAS with the P13K p110 alpha subunit mediates RAS-driven tumor development: however, it is not clear how p110 alpha/RAS-dependant signaling mediates interactions between tumors and host tissues. Here, using a murine tumor cell t
Autor:
Esther Castellano, Markus E. Diefenbacher, Christopher Moore, Madhu S. Kumar, Francois Lassailly, Bradley Spencer-Dene, Clare Sheridan, Julian Downward, Eva Grönroos, Gordon Stamp, Miguel M. Murillo, May Zaw Thin, Emma Nye
Publikováno v:
Cancer Cell
Summary RAS proteins directly activate PI3-kinases. Mice bearing a germline mutation in the RAS binding domain of the p110α subunit of PI3-kinse are resistant to the development of RAS-driven tumors. However, it is unknown whether interaction of RAS
Autor:
Eva Durán‐Martín, Carmen Vives‐Cases, Laura Otero‐García, Esther Castellanos‐Torres, Belen Sanz‐Barbero
Publikováno v:
Health Expectations, Vol 25, Iss 3, Pp 1058-1068 (2022)
Abstract Introduction Women experiencing intimate partner violence (IPV) do not tend to go very frequently to formal support services. The objective of this study is to identify barriers related to the accessibility, acceptability, equity, appropriat
Externí odkaz:
https://doaj.org/article/d6feb5d52ce743f8ab015bf212e1bb25