DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity

Autor: Maria Jure-Kunkel, Homer C Adams III, Kate Sasser, Mark Fereshteh, Alexander Muik, Isil Altintas, Friederike Gieseke, Aras Toker, Özlem Türeci, Tahamtan Ahmadi, Ugur Sahin, Dennis Verzijl, Kristina B Schoedel, Jordan M Blum, Bianca Sänger, Saskia M Burm, Eliana Stanganello, Vanessa M Spires, Fulvia Vascotto, Juliane Quinkhardt, Mustafa Diken, David P E Satijn, Sebastian Kreiter, Esther C W Breij

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)

Externí odkaz: https://doaj.org/article/026b8577fc804412a127d45c0c573c04

Epcoritamab induces potent anti-tumor activity against malignant B-cells from patients with DLBCL, FL and MCL, irrespective of prior CD20 monoclonal antibody treatment

Autor: Hilma J. van der Horst, A. Vera de Jonge, Ida H. Hiemstra, Anne T. Gelderloos, Daniella R. A. I. Berry, Nathalie J. Hijmering, Hendrik F. van Essen, Daphne de Jong, Martine E. D. Chamuleau, Sonja Zweegman, Esther C. W. Breij, Margaretha G. M. Roemer, Tuna Mutis

Publikováno v: Blood Cancer Journal, Vol 11, Iss 2, Pp 1-8 (2021)

Abstract Epcoritamab (DuoBody-CD3xCD20, GEN3013) is a novel bispecific IgG1 antibody redirecting T-cells toward CD20+ tumor cells. Here, we assessed the preclinical efficacy of epcoritamab against primary tumor cells present in the lymph node biopsie

Externí odkaz: https://doaj.org/article/1763543d37b64f68b1819cf9d59358d5

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering

Autor: Simone C. Oostindie, Hilma J. van der Horst, Margaret A. Lindorfer, Erika M. Cook, Jillian C. Tupitza, Clive S. Zent, Richard Burack, Karl R. VanDerMeid, Kristin Strumane, Martine E. D. Chamuleau, Tuna Mutis, Rob N. de Jong, Janine Schuurman, Esther C. W. Breij, Frank J. Beurskens, Paul W. H. I. Parren, Ronald P. Taylor

Publikováno v: Haematologica, Vol 104, Iss 9 (2019)

CD20 monoclonal antibody therapies have significantly improved the outlook for patients with B-cell malignancies. However, many patients acquire resistance, demonstrating the need for new and improved drugs. We previously demonstrated that the natura

Externí odkaz: https://doaj.org/article/8951ab20ead14f0a871191432d4962ce

Systematic study of tissue factor expression in solid tumors

Autor: Johann S. de Bono, Jeffrey R. Harris, Saskia M. Burm, Adriaan Vanderstichele, Mischa A. Houtkamp, Saida Aarass, Ruth Riisnaes, Ines Figueiredo, Daniel Nava Rodrigues, Rossitza Christova, Siel Olbrecht, Hans W. M. Niessen, Sigrid R. Ruuls, Danita H. Schuurhuis, Jeroen J. Lammerts van Bueren, Esther C. W. Breij, Ignace Vergote

Publikováno v: de Bono, J S, Harris, J R, Burm, S M, Vanderstichele, A, Houtkamp, M A, Aarass, S, Riisnaes, R, Figueiredo, I, Nava Rodrigues, D, Christova, R, Olbrecht, S, Niessen, H W M, Ruuls, S R, Schuurhuis, D H, Lammerts van Bueren, J J, Breij, E C W & Vergote, I 2022, ' Systematic study of tissue factor expression in solid tumors ', Cancer reports (Hoboken, N.J.) . https://doi.org/10.1002/cnr2.1699
Cancer reports (Hoboken, N.J.). Wiley-Blackwell Publishing Ltd

BACKGROUND: Elevated tissue factor (TF) expression, although restricted in normal tissue, has been reported in multiple solid cancers, and expression has been associated with poor prognosis. This manuscript compares TF expression across various solid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7963355661e32638ebfa646c3038ae79
https://doi.org/10.1002/cnr2.1699

Homogeneity of active demyelinating lesions in established multiple sclerosis

Autor: Bianca P. Brink, Esther C W Breij, Christa van den Berg, R. Veerhuis, Christine D. Dijkstra, Rianka P. M. Vloet, Lars Bø, Riqiang Yan, Paul van der Valk

Publikováno v: Annals of Neurology, 63(1), 16-25. John Wiley and Sons Inc.
Breij, E C W, Brink, B P, Veerhuis, R, van den Berg, C, Vloet, R, Yan, R, Dijkstra, C D, van der Valk, P & Bo, L 2008, ' Homogeneity of active demyelinating lesions in established multiple sclerosis ', Annals of Neurology, vol. 63, no. 1, pp. 16-25 . https://doi.org/10.1002/ana.21311

Objective: Four different patterns of demyelination have been described in active demyelinating lesions of multiple sclerosis (MS) patients that were biopsied shortly after disease onset. These patterns were suggested to represent heterogeneity of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140a98630a66eb0625f028f7660a9ff9
https://doi.org/10.1002/ana.21311