Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Esther B E, Becker"'
Autor:
Max J. van Essen, Elizabeth J. Apsley, Joey Riepsaame, Ruijie Xu, Paul A. Northcott, Sally A. Cowley, John Jacob, Esther B. E. Becker
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/6dd8bd19ab6c4c6d90c14eaf46139909
Autor:
Bethan A. Cole, Esther B. E. Becker
Publikováno v:
Cells, Vol 12, Iss 18, p 2215 (2023)
Canonical transient receptor potential 3 (TRPC3) channel is a non-selective cation permeable channel that plays an essential role in calcium signalling. TRPC3 is highly expressed in the brain and also found in endocrine tissues and smooth muscle cell
Externí odkaz:
https://doaj.org/article/886b0c08b1934b4889cf1e99abe63f93
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Current protocols for producing cerebellar neurons from human pluripotent stem cells (hPSCs) often rely on animal co-culture and mostly exist as monolayers, limiting their capability to recapitulate the complex processes in the developing ce
Externí odkaz:
https://doaj.org/article/bef6046921e74ab3991c714a8e11396e
Publikováno v:
Cells, Vol 11, Iss 18, p 2918 (2022)
Despite their homogeneous appearance, Purkinje cells are remarkably diverse with respect to their molecular phenotypes, physiological properties, afferent and efferent connectivity, as well as their vulnerability to insults. Heterogeneity in Purkinje
Externí odkaz:
https://doaj.org/article/ef61444df3104bc2b7e9550e4bada425
Publikováno v:
PLoS Genetics, Vol 16, Iss 4, p e1008630 (2020)
The cerebellum is a pivotal centre for the integration and processing of motor and sensory information. Its extended development into the postnatal period makes this structure vulnerable to a variety of pathologies, including neoplasia. These propert
Externí odkaz:
https://doaj.org/article/a769b56466644a36a930919be7a005f7
Autor:
Maggie M. K. Wong, Stephanie D. Hoekstra, Jane Vowles, Lauren M. Watson, Geraint Fuller, Andrea H. Németh, Sally A. Cowley, Olaf Ansorge, Kevin Talbot, Esther B. E. Becker
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Spinocerebellar ataxia type 14 (SCA14) is a subtype of the autosomal dominant cerebellar ataxias that is characterized by slowly progressive cerebellar dysfunction and neurodegeneration. SCA14 is caused by mutations in the PRKCG gene, encodi
Externí odkaz:
https://doaj.org/article/d36835a4edd448ddb8d5f839cc6adf53
SummaryPatched 1 (PTCH1) is the primary receptor for Sonic Hedgehog (SHH) ligand and negatively regulates SHH signalling, an essential pathway in human embryogenesis. Loss-of-function mutations inPTCH1are associated with altered neuronal development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8406be046014c426aa39438eb60a2ac5
https://doi.org/10.1101/2023.05.10.540200
https://doi.org/10.1101/2023.05.10.540200
Publikováno v:
Essentials of Cerebellum and Cerebellar Disorders ISBN: 9783031150692
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28245ccf5bc60585b3db980651c200b3
https://doi.org/10.1007/978-3-031-15070-8_69
https://doi.org/10.1007/978-3-031-15070-8_69
Autor:
Samuel P. Nayler, Esther B. E. Becker
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
The cerebellum is a fascinating brain structure, containing more neurons than the rest of the brain combined. The cerebellum develops according to a highly orchestrated program into a well-organized laminar structure. Much has been learned about the
Externí odkaz:
https://doaj.org/article/e22d285e5f064cd2ba3470fca3ecaba8
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
Current protocols for producing cerebellar neurons from human pluripotent stem cells (hPSCs) often rely on animal co-culture and mostly exist as monolayers, limiting their capability to recapitulate the complex processes in the developing cerebellum.