Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Esther A. Epum"'
Publikováno v:
PLoS Genetics, Vol 16, Iss 2, p e1008608 (2020)
DNA double-strand breaks (DSBs) are toxic forms of DNA damage that must be repaired to maintain genome integrity. Telomerase can act upon a DSB to create a de novo telomere, a process that interferes with normal repair and creates terminal deletions.
Externí odkaz:
https://doaj.org/article/f7c7607b01844026a0659c2e56e471f4
Autor:
James E. Haber, Esther A. Epum
Publikováno v:
Trends Cell Biol
The failure to complete DNA replication is one of the major sources of genome instability that leads to aneuploidy, chromosome breakage, and chromosome rearrangements associated with human cancer. One of the surprising revelations of the past decade
Publikováno v:
Curr Genet
DNA double-strand break repair allows cells to survive both exogenous and endogenous insults to the genome. In yeast, the recombinases Rad51 and Rad52 are central to multiple forms of homology-dependent repair. Classically, Rad51 and Rad52 are though
Interaction of yeast Rad51 and Rad52 relieves Rad52-mediated inhibition of de novo telomere addition
Publikováno v:
PLoS Genetics, Vol 16, Iss 2, p e1008608 (2020)
PLoS Genetics
PLoS Genetics
DNA double-strand breaks (DSBs) are toxic forms of DNA damage that must be repaired to maintain genome integrity. Telomerase can act upon a DSB to create a de novo telomere, a process that interferes with normal repair and creates terminal deletions.
Autor:
Elizabeth O’Brien, Katherine L. Friedman, Jacqueline K. Barton, Esther A. Epum, Walter J. Chazin, Lauren E. Salay
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 52
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Redox switching driven by [4Fe4S] cluster cofactors modulates DNA binding affinity in proteins, providing a rapid, efficient method of substrate binding and dissociation. Our study establishes an essential redox switch with an aromatic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611850616987a9703587091902fa51b9
https://escholarship.org/uc/item/4v81c584
https://escholarship.org/uc/item/4v81c584
Autor:
Udochukwu C. Obodo, Shira R. Paul, Nicole A. Dahlson, Margaret H. Platts, Jacob Seloff, Esther A. Epum, Stoycho M. Velkovsky, Katherine L. Friedman
Publikováno v:
Molecular and cellular biology. 36(12)
DNA double-strand breaks (DSBs) pose a threat to genome stability and are repaired through multiple mechanisms. Rarely, telomerase, the enzyme that maintains telomeres, acts upon a DSB in a mutagenic process termed telomere healing. The probability o