Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Esther, Tijchon"'
1
Akademický článek
Inducible MLL-AF9 Expression Drives an AML Program during Human Pluripotent Stem Cell-Derived Hematopoietic Differentiation
Autor: Branco M. H. Heuts, Saioa Arza-Apalategi, Sinne G. Alkema, Esther Tijchon, Laura Jussen, Saskia M. Bergevoet, Bert A. van der Reijden, Joost H. A. Martens
Publikováno v: Cells, Vol 12, Iss 8, p 1195 (2023)
A t(9;11)(p22;q23) translocation produces the MLL-AF9 fusion protein, which is found in up to 25% of de novo AML cases in children. Despite major advances, obtaining a comprehensive understanding of context-dependent MLL-AF9-mediated gene programs du
Externí odkaz: https://doaj.org/article/27d347a2f29245cab22550f2fa2c38ab
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2
Akademický článek
The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model.
Autor: Esther Tijchon, Guoqiang Yi, Amit Mandoli, Jos G A Smits, Francesco Ferrari, Branco M H Heuts, Falco Wijnen, Bowon Kim, Eva M Janssen-Megens, Jan Jacob Schuringa, Joost H A Martens
Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0226435 (2019)
Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect normal hematopoiesis. The analysis of human AMLs has mostly been performed using end-point materials, such as cell lines and patient derived AMLs that also carry additio
Externí odkaz: https://doaj.org/article/c2d8cbfea6314d7495286f1c3efb457d
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3
Inducible MLL-AF9 expression drives an AML program during human pluripotent stem cell-derived hematopoietic differentiation
Autor: Branco Heuts, Saioa Arza-Apalategi, Sinna Alkema, Esther Tijchon, Laura Jussen, Saskia Bergevoet, Bert van der Reijden, Joost H. A. Martens
A t(9;11)(p22;q23) translocation produces the MLL-AF9 fusion protein, which is found in up to 25% of de novo AML cases in children. Despite major advances, obtaining a comprehensive understanding of context-dependent MLL-AF9-mediated gene programs du
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af6664e2950a51ae1d66deb9b6d711c1
https://doi.org/10.21203/rs.3.rs-2521405/v1
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4
Akademický článek
Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients
Autor: Blanca Scheijen, Judith M. Boer, René Marke, Esther Tijchon, Dorette van Ingen Schenau, Esmé Waanders, Liesbeth van Emst, Laurens T. van der Meer, Rob Pieters, Gabriele Escherich, Martin A. Horstmann, Edwin Sonneveld, Nicola Venn, Rosemary Sutton, Luciano Dalla-Pozza, Roland P. Kuiper, Peter M. Hoogerbrugge, Monique L. den Boer, Frank N. van Leeuwen
Publikováno v: Haematologica, Vol 102, Iss 3 (2017)
Deletions and mutations affecting lymphoid transcription factor IKZF1 (IKAROS) are associated with an increased relapse risk and poor outcome in B-cell precursor acute lymphoblastic leukemia. However, additional genetic events may either enhance or n
Externí odkaz: https://doaj.org/article/4b9e33dbdf0346af888f8b42df273b6a
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6
Akademický článek
Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton.
Autor: Esther Tijchon, Dorette van Ingen Schenau, Fred van Opzeeland, Felice Tirone, Peter M Hoogerbrugge, Frank N Van Leeuwen, Blanca Scheijen
Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0131481 (2015)
Btg1 and Btg2 encode highly homologous proteins that are broadly expressed in different cell lineages, and have been implicated in different types of cancer. Btg1 and Btg2 have been shown to modulate the function of different transcriptional regulato
Externí odkaz: https://doaj.org/article/99908c2bce9342849a4752f2671e8943
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7
CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1
Autor: Marten Hansen, Esther Tijchon, Laura Jussen, Pascal W. T. C. Jansen, Luan Nguyen, Guoqiang Yi, Jonathan Bond, Michiel Vermeulen, Bert A. van der Reijden, Joost H.A. Martens, Emile van den Akker, Maaike G.J.M. van Bergen, Amit Mandoli, Gaëlle Cordonnier, Bowon Kim
Publikováno v: Blood Cancer Journal, Vol 9, Iss 3, Pp 1-13 (2019)
Blood Cancer Journal, 9, 33
Blood Cancer Journal
Blood cancer journal, 9(3):33. Nature Publishing Group
Blood Cancer Journal, 9, 3, pp. 33
The inv(16) acute myeloid leukemia-associated CBFβ-MYH11 fusion is proposed to block normal myeloid differentiation, but whether this subtype of leukemia cells is poised for a unique cell lineage remains unclear. Here, we surveyed the functional con
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700acae5b654a82e9a9bdd5289960f87
http://link.springer.com/article/10.1038/s41408-019-0194-8
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8
Akademický článek
The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME.
Autor: Adalberto Costessi, Nawel Mahrour, Vikram Sharma, Rieka Stunnenberg, Marieke A Stoel, Esther Tijchon, Joan W Conaway, Ronald C Conaway, Hendrik G Stunnenberg
Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42822 (2012)
The human tumour antigen PRAME (preferentially expressed antigen in melanoma) is frequently overexpressed during oncogenesis, and high PRAME levels are associated with poor clinical outcome in a variety of cancers. However, the molecular pathways in
Externí odkaz: https://doaj.org/article/83a38e0689f5471b9000667dd21d99a6
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9
RUNX1 mutations enhance self-renewal and block granulocytic differentiation in human in vitro models and primary AMLs
Autor: Edo Vellenga, Esther Tijchon, Mylène Gerritsen, Joost H.A. Martens, Guoqiang Yi, Jorren Kuster, Jan Jacob Schuringa
Publikováno v: Blood Advances, 3, 3, pp. 320-332
Blood Advances, 3, 320-332
Blood, 3(3), 320-332. AMER SOC HEMATOLOGY
To unravel molecular mechanisms by which Runt-related transcription factor 1 (RUNX1) mutations contribute to leukemic transformation, we introduced the RUNX1-S291fs300X mutation in human CD34+ stem/progenitor cells and in human induced pluripotent st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0555057859d01e73ab5b81303a9f2e
https://hdl.handle.net/2066/201413
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10
The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model
Autor: Guoqiang Yi, Branco M. H. Heuts, Francesco Ferrari, Jan Jacob Schuringa, Eva M. Janssen-Megens, Esther Tijchon, Amit Mandoli, Jos G. A. Smits, Bowon Kim, Falco Wijnen, Joost H.A. Martens
Publikováno v: PLoS One, 14
PLoS ONE, Vol 14, Iss 12, p e0226435 (2019)
PLoS One, 14, 12
PLoS ONE
PLoS ONE, 14(12):0226435. PUBLIC LIBRARY SCIENCE
Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect normal hematopoiesis. The analysis of human AMLs has mostly been performed using end-point materials, such as cell lines and patient derived AMLs that also carry additio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca67d382a738dc1f542cb251b0e26df
http://hdl.handle.net/2066/219175
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