Unmasking Arrhythmogenic Hubs of Reentry Driving Persistent Atrial Fibrillation for Patient‐Specific Treatment

Autor: Brian J. Hansen, Jichao Zhao, Katelynn M. Helfrich, Ning Li, Alexander Iancau, Alexander M. Zolotarev, Stanislav O. Zakharkin, Anuradha Kalyanasundaram, Megan Subr, Nawshin Dastagir, Roshan Sharma, Esthela J. Artiga, Nicholas Salgia, Mustafa M. Houmsse, Omar Kahaly, Paul M. L. Janssen, Peter J. Mohler, Nahush A. Mokadam, Bryan A. Whitson, Muhammad R. Afzal, Orlando P. Simonetti, John D. Hummel, Vadim V. Fedorov

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 19 (2020)

Background Atrial fibrillation (AF) driver mechanisms are obscured to clinical multielectrode mapping approaches that provide partial, surface‐only visualization of unstable 3‐dimensional atrial conduction. We hypothesized that transient modulati

Externí odkaz: https://doaj.org/article/8f6472004e244b198cbef26b3fa05dbc

Comprehensive evaluation of electrophysiological and 3D structural features of human atrial myocardium with insights on atrial fibrillation maintenance mechanisms

Autor: Jichao Zhao, Brian J. Hansen, Anuradha Kalyanasundaram, Aleksei Mikhailov, Vadim V. Fedorov, Shane S. Scott, Ning Li, John D. Hummel, Esthela J. Artiga, Megan Subr

Publikováno v: J Mol Cell Cardiol

Atrial fibrillation (AF) occurrence and maintenance is associated with progressive remodeling of electrophysiological (repolarization and conduction) and 3D structural (fibrosis, fiber orientations, and wall thickness) features of the human atria. Si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edca7790b4b032b9eb09e7e0b8accfa6
https://doi.org/10.1016/j.yjmcc.2020.10.012

Abstract 14223: Identifying Pro-fibrotic Long Non-coding RNAs Ii Fibroblasts From the Failing and Non-failing Human Sinoatrial Node

Autor: Mike Freitas, Nahush A. Mokadam, Miranda L. Gardner, Paul M.L. Janssen, Ning Li, Vadim V. Fedorov, Maciej Pietrzak, Bryan A. Whitson, Brian J. Hansen, Esthela J. Artiga, Anuradha Kalyanasundaram, Peter J. Mohler, Katelynn M. Helfrich

Publikováno v: Circulation. 142

Introduction: Dense fibrous connective tissue is inherently found in the human sinoatrial node (hSAN), which further increases in heart failure (HF) leading to sinoatrial node dysfunction (SND). While several factors contribute to cardiac fibrosis, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40c399d8374f82f9d21a71425d8a217c
https://doi.org/10.1161/circ.142.suppl_3.14223

Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

Autor: Vadim V. Fedorov, Jichao Zhao, Ning Li, Brian J. Hansen, Peter J. Mohler, Sándor Györke, Roshan Sharma, Galina Rozenberg, Paul M.L. Janssen, Katelynn M. Helfrich, Stanislav O. Zakharkin, Bryan A. Whitson, Halina Dobrzynski, Pei Jung Wu, Anuradha Kalyanasundaram, Suhaib H. Abudulwahed, Esthela J. Artiga, John D. Hummel, Federica Accornero, Brandon J. Biesiadecki, Nahush A. Mokadam

Publikováno v: Li, N, Kalyanasundaram, A, Hansen, B J, Artiga, E J, Sharma, R, Abudulwahed, S H, Helfrich, K M, Rozenberg, G, Wu, P-J, Zakharkin, S, Gyorke, S, Janssen, P, Whitson, B A, Mokadam, N A, Biesiadecki, B J, Accornero, F, Hummel, J D, Jichao Zhao, J, Mohler, P J, Dobrzynski, H & Fedorov, V V 2020, ' Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node ', Nature Communications, vol. 11, no. 1, 512, pp. 512 . https://doi.org/10.1038/s41467-019-14039-8
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications

Mechanisms for human sinoatrial node (SAN) dysfunction are poorly understood and whether human SAN excitability requires voltage-gated sodium channels (Nav) remains controversial. Here, we report that neuronal (n)Nav blockade and selective nNav1.6 bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a93e9c4e29410729a773cc9c04368c
https://doi.org/10.1038/s41467-019-14039-8

Defining the SAN fibrotic content in failing hearts

Autor: Esthela J. Artiga, Ning Li, Nahush A. Mokadam, Bryan A. Whitson, Michael A. Freitas, Peter J. Mohler, Paul M.L. Janssen, Anuradha Kalyanasundaram, Vadim V. Fedorov, Brian J. Hansen, Amy Webb, Maciej Pietrzak, Miranda L. Gardner

Publikováno v: Circulation

Background: Up to 50% of the adult human sinoatrial node (SAN) is composed of dense connective tissue. Cardiac diseases including heart failure (HF) may increase fibrosis within the SAN pacemaker complex, leading to impaired automaticity and conducti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8086b5366b022118491945867b70fe49
https://doi.org/10.1038/s41569-021-00565-w