Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.

Autor: Estevam GO; Tetrad Graduate Program, University of California, San Francisco, San Francisco, United States.; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, United States., Linossi EM; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States., Macdonald CB; Tetrad Graduate Program, University of California, San Francisco, San Francisco, United States., Espinoza CA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, United States.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States., Michaud JM; Tetrad Graduate Program, University of California, San Francisco, San Francisco, United States., Coyote-Maestas W; Tetrad Graduate Program, University of California, San Francisco, San Francisco, United States.; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, United States., Collisson EA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, United States.; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, United States., Jura N; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States.; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, United States., Fraser JS; Tetrad Graduate Program, University of California, San Francisco, San Francisco, United States.; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, United States.

Publikováno v: ELife [Elife] 2024 Sep 13; Vol. 12. Date of Electronic Publication: 2024 Sep 13.

Rosace: a robust deep mutational scanning analysis framework employing position and mean-variance shrinkage.

Autor: Rao J; Department of Computer Science, UCLA, Los Angeles, CA, USA., Xin R; Computational and Systems Biology Interdepartmental Program, UCLA, Los Angeles, CA, USA., Macdonald C; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA, USA., Howard MK; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA, USA.; Tetrad Graduate Program, UCSF, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, UCSF, San Francisco, CA, USA., Estevam GO; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA, USA.; Tetrad Graduate Program, UCSF, San Francisco, CA, USA., Yee SW; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA, USA., Wang M; Department of Mathematics, Baruch College, CUNY, New York, NY, USA., Fraser JS; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA, USA.; Quantitative Biosciences Institute, UCSF, San Francisco, CA, USA., Coyote-Maestas W; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA, USA. willow.coyote-maestas@ucsf.edu.; Quantitative Biosciences Institute, UCSF, San Francisco, CA, USA. willow.coyote-maestas@ucsf.edu., Pimentel H; Department of Computer Science, UCLA, Los Angeles, CA, USA. hjp@ucla.edu.; Department of Computational Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. hjp@ucla.edu.; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. hjp@ucla.edu.

Publikováno v: Genome biology [Genome Biol] 2024 May 24; Vol. 25 (1), pp. 138. Date of Electronic Publication: 2024 May 24.

MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation.

Autor: Guérin C, Vinchent A, Fernandes M, Damour I, Laratte A, Tellier R, Estevam GO, Meneboo JP, Villenet C, Descarpentries C, Fraser JS, Figeac M, Cortot AB, Rouleau E, Tulasne D

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 07. Date of Electronic Publication: 2023 Nov 07.