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Atroxlysin-III, A Metalloproteinase from the Venom of the Peruvian Pit Viper Snake Bothrops atrox (Jergón) Induces Glycoprotein VI Shedding and Impairs Platelet Function.

Autor: Oliveira LS; Research and Development Center, Ezequiel Dias Foundation, 30510-010 Belo Horizonte, MG, Brazil. luciana.oliveira@funed.mg.gov.br., Estevão-Costa MI; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, 48149 Münster, Germany. mina.estevao@gmail.com., Alvarenga VG; Research and Development Center, Ezequiel Dias Foundation, 30510-010 Belo Horizonte, MG, Brazil. valeria.alvarenga@funed.mg.gov.br., Vivas-Ruiz DE; Laboratorio de Biología Molecular-Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos, Av. Venezuela Cdra 34 S/N, Ciudad Universitaria, Lima 01, Lima 14-0576, Peru. dvivasr@unmsm.edu.pe., Yarleque A; Laboratorio de Biología Molecular-Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos, Av. Venezuela Cdra 34 S/N, Ciudad Universitaria, Lima 01, Lima 14-0576, Peru. ayarlequec@unmsm.edu.pe., Lima AM; Laboratory of Hemodynamics and Cardiovascular Technology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. augusto.martinslima@epfl.ch., Cavaco A; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, 48149 Münster, Germany. acmcavaco@gmail.com., Eble JA; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, 48149 Münster, Germany. johannes.eble@uni-muenster.de., Sanchez EF; Research and Development Center, Ezequiel Dias Foundation, 30510-010 Belo Horizonte, MG, Brazil. eladio.flores@funed.mg.gov.br.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2019 Sep 26; Vol. 24 (19). Date of Electronic Publication: 2019 Sep 26.

The spatial molecular pattern of integrin recognition sites and their immobilization to colloidal nanobeads determine α2β1 integrin-dependent platelet activation.

Autor: Lima AM; Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Waldeyerstr. 15, 48149 Muenster, Germany., Wegner SV; Department of Biophysical Chemistry, University of Heidelberg, Heidelberg, Germany, and Max Plank-Institute for Polymer Research, Mainz, Germany., Martins Cavaco AC; Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Waldeyerstr. 15, 48149 Muenster, Germany., Estevão-Costa MI; Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Waldeyerstr. 15, 48149 Muenster, Germany., Sanz-Soler R; Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Waldeyerstr. 15, 48149 Muenster, Germany., Niland S; Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Waldeyerstr. 15, 48149 Muenster, Germany., Nosov G; Institute for Physical Medicine and Biophysics, University of Muenster, Muenster, Germany., Klingauf J; Institute for Physical Medicine and Biophysics, University of Muenster, Muenster, Germany., Spatz JP; Department of Biophysical Chemistry, University of Heidelberg, Heidelberg, Germany, and Max Planck-Institute for Medical Research, Department of Cellular Biophysics, Heidelberg, Germany., Eble JA; Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Waldeyerstr. 15, 48149 Muenster, Germany. Electronic address: johannes.eble@uni-muenster.de.

Publikováno v: Biomaterials [Biomaterials] 2018 Jun; Vol. 167, pp. 107-120. Date of Electronic Publication: 2018 Mar 16.

Dramatic and concerted conformational changes enable rhodocetin to block α2β1 integrin selectively.

Autor: Eble JA; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany., McDougall M; Departments of Chemistry & Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., Orriss GL; Departments of Chemistry & Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., Niland S; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany., Johanningmeier B; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany., Pohlentz G; Institute of Hygiene, University of Münster, Münster, Germany., Meier M; Departments of Chemistry & Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., Karrasch S; Departments of Chemistry & Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., Estevão-Costa MI; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany., Martins Lima A; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany., Stetefeld J; Departments of Chemistry & Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.

Publikováno v: PLoS biology [PLoS Biol] 2017 Jul 13; Vol. 15 (7), pp. e2001492. Date of Electronic Publication: 2017 Jul 13 (Print Publication: 2017).