Výsledky vyhledávání - "Estera Touboul"

Potent antihyperglycaemic property of a new imidazoline derivative S-22068 (PMS 847) in a rat model of NIDDM

Autor: Xuan Wang, Agnès Pelé-Tounian, Bruno Pfeiffer, Sylvie Marc, Frédéric Rondu, Alain Ktorza, Beatrice Guardiola-Lemaitre, Luc Pénicaud, Dominique Manechez, Pierre Renard, Azzdine Lamouri, Estera Touboul, Raymond Dokhan, Jean-Jacques Godfroid

Publikováno v: British Journal of Pharmacology. 124:1591-1596

Recent data suggest that some imidazoline derivatives can lower plasma glucose in experimental animal models of diabetes. We studied the activity of an imidazoline S-22068, in rat model of non-insulin-dependent diabetes mellitus (NIDDM) produced with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::568f620ef306c5d628fc658728cdd25a
https://doi.org/10.1038/sj.bjp.0701989

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Design and modeling of new platelet-activating factor antagonists. 2. Synthesis and biological activity of 1,4-bis-(3′,4′,5′-trimethoxybenzoyl)-2-alkyl and 2-alkyloxymethylpiperazines

Autor: Georges Dive, Estera Touboul, Nicole Blavet, Aazdine Lamouri, Fabrice Tavet, Françoise Heymans, Jean-Jacques Godfroid

Publikováno v: Journal of Lipid Mediators and Cell Signalling. 15:145-159

In the continuation of our investigations on the structure of platelet-activating factor (PAF)-receptor, 25 additional 2-substituted 1,4-bis-(poly- and mono methoxybenzoyl)-piperazines were synthesized and their in vitro biological activities measure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63179c1f5810fd19d6f2cf527461a58f
https://doi.org/10.1016/s0929-7855(96)00551-2

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ChemInform Abstract: Remote Stereochemical Control of the Ring Conformation of 2-Bromo-3- methyl-4-alkyl-butyrolactones

Autor: Estera Touboul, Mariam Mellot-Srour, Gilbert Dana

Publikováno v: ChemInform. 23

The lactones 2a and 2b are different only by the configurationof the carbon C5 of the side-chain, but present quite different features in the ring conformation. Inspection of the NMR spectra of 2b , compared to 2a , shows a evident flattening of the

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https://doi.org/10.1002/chin.199224150

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Remote stereochemical control of the ring conformation of 2-bromo-3-methyl-4-alkyl-butyrolactones

Autor: Estera Touboul, Mariam Mellot-Srour, Gilbert Dana

Publikováno v: Tetrahedron. 48:1617-1626

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1da5ea8f0f93e744bea67d6b629f35fb
https://doi.org/10.1016/s0040-4020(01)88720-2

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Anomeric and steric effects of bromine, chlorine and methoxy-group in conformational analysis and anomerization of hindered tetrahydrofurans

Autor: Odile Convert, Gilbert Dana, Estera Touboul

Publikováno v: Tetrahedron. 46:5621-5632

The NMR spectra of a series of hindered tetrahydrofuran compounds, disubstituted in C5 and with two polar groups in C2 (Br, Cl or OMe in the anomeric position) and C3 (Br or Cl) have been examined. When the two polar groups are cis, the anomeric grou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b16cf435fa82385dbcfa3cd46c4708cd
https://doi.org/10.1016/s0040-4020(01)87762-0

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Anomeric effect and infra-red υCD stretching frequency in tetrahydropyran compounds

Autor: Gilbert Dana, Estera Touboul

Publikováno v: Tetrahedron Letters. 31:3549-3552

The stretching frequencies of equatorial and axial fused tetrahydropen C 2 -D bonds appear around 2190 and 2100 cm −1 , with a wide multiplicity. These frequencies are lowered by 20 to 70 cm −1 when an OR group is added on C2. An sp 2 hybridizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d51339e9e03f1b118144be9a7923bcc
https://doi.org/10.1016/s0040-4039(00)94439-3

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Structure-activity relationships in platelet-activating factor (PAF). 11-From PAF-antagonism to phospholipase A(2) inhibition: syntheses and structure-activity relationships in 1-arylsulfamido-2-alkylpiperazines

Autor: Chang-Zhi Dong, Jack Huet, Françoise Heymans, Léon Assogba, Catherine Redeuilh, Carine Mounier, Carine Binisti, Estera Touboul, Jean-Edouard Ombetta, Jean-Jacques Godfroid

Publikováno v: European journal of medicinal chemistry. 36(10)

1-Benzoyl-2-alkyl piperazines are strong inhibitors of Group I and II secreted PLA2s. An improvement of their activity was obtained by replacing the amide function by a sulfamide and by introduction of electrodonor substituents on the para position o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ac7d887e9ad441ea3d58153e717547
https://pubmed.ncbi.nlm.nih.gov/11738488

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Effect of the new imidazoline derivative S-22068 (PMS 847) on insulin secretion in vitro and glucose turnover in vivo in rats

Autor: Beatrice Guardiola-Lemaitre, Susan L.F. Chan, Agnès Pelé-Tounian, Dominique Manechez, Frédéric Rondu, Noel G. Morgan, Azzdine Lamouri, Estera Touboul, Alain Ktorza, Marie-Hélène Giroix, Luc Pénicaud, Jean-Jacques Godfroid, Bruno Pfeiffer, Pierre Renard, Gaëlle Le Bihan

Publikováno v: European Journal of Pharmacology
European Journal of Pharmacology, Elsevier, 1999, 377 (1), pp.81-7

We have investigated the possible mechanisms underlying the antihyperglycaemic effect of the imidazoline derivative S-22068. In vitro, in the presence of 5 mmol/l glucose, S-22068 (100 micromol/l) induced a significant and sustained increase in insul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e190ab8df70e520b68c8b7937a23b3
https://hal.archives-ouvertes.fr/hal-00394147

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A new phospholipase A2 inhibitor, unrelated to substrate analogues: kinetic characterization of the inhibition of secretory phospholipases A2 by PMS 832

Autor: Carine Mounier, Carine Binisti, Cassian Bon, Estera Touboul, Françoise Heymans, Jean-Jacques Godfroid

Publikováno v: Journal of lipid mediators and cell signalling. 16(3)

Starting from a series of compounds which were known to be PAF antagonists, we have synthesized molecules that are good inhibitors of PLA2s of groups I or II, with IC50 in the micromolar range (Binisti et al., 1997). In this report we investigate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723cf5a22e41b3c992576d9285e5e943
https://pubmed.ncbi.nlm.nih.gov/9246606

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