Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Estera Pawlisz"'
Autor:
Korinna Henseleit, Mark Frigerio, Antony Godwin, Jeff Edwards, XiaoBo Sheng, Matthew Bird, Martin Fisher, Kosma Jurlewicz, George Badescu, Amrita Abhilash, Penny Bryant, Estera Pawlisz, Ruslan Grygorash, Julia Swierkosz, Andrew F. Kyle, Monika Farys, Nicolas Camper, Vimal Parekh, Rita Tommasi
Publikováno v:
Bioconjugate Chemistry. 25:1124-1136
To improve both the homogeneity and the stability of ADCs, we have developed site-specific drug-conjugating reagents that covalently rebridge reduced disulfide bonds. The new reagents comprise a drug, a linker, and a bis-reactive conjugating moiety t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2e41ca810ded9c08bfb53bf05fccd1
https://doi.org/10.1021/bc500148x
https://doi.org/10.1021/bc500148x
Autor:
Steve Brocchini, Karolina Peciak, Estera Pawlisz, Claire Ginn, George Badescu, Monika Farys, Hanieh Khalili
Publikováno v:
Pharmaceutical Sciences Encyclopedia
There are many natural post-translational modifications of proteins (e.g., glycosylation, ubiquitination, acylation,and amino acid derivatization).Glycosylation is common for therapeutic proteins. Classes of proteins modified by glycosylation include
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a7fab15b045a8a4e63af1134486e393
https://doi.org/10.1002/9780470571224.pse508
https://doi.org/10.1002/9780470571224.pse508
Autor:
Antony Godwin, Emmanuelle Laurine, Yuehua Cong, Penny Bryant, Matthew Bird, Julia Swierkosz, Ji-Won Choi, Karolina Peciak, Sitara Dubey, Jeff Edwards, Mire Zloh, Ian Hodgson, Rita Tommasi, Sibylle Heidelberger, Farzad Khayrzad, Ruchi Singh, Amrita Sivasankar, Charles Heise, Estera Pawlisz, George Badescu, John Liddell, Sibu Balan, Keith Powell, Monika Farys, Maurizio Muroni, Satyanarayana Somavarapu, Steve Brocchini
Publikováno v:
Bioconjugate chemistry. 23(2)
The efficacy of protein-based medicines can be compromised by their rapid clearance from the blood circulatory system. Achieving optimal pharmacokinetics is a key requirement for the successful development of safe protein-based medicines. Protein PEG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c695e99fa036e035a072d2a6876250f8
https://pubmed.ncbi.nlm.nih.gov/22243664
https://pubmed.ncbi.nlm.nih.gov/22243664
Autor:
Penny Bryant, Sibu Balan, Ji-Won Choi, Manuchehr Porssa, Estera Pawlisz, Steve Brocchini, Yuehua Cong, Ruchi Singh, Norbert Rumpf, Antony Godwin, Keith Powell
Publikováno v:
PEGylated Protein Drugs: Basic Science and Clinical Applications ISBN: 9783764386788
Site-specific PEGylation reagents have been developed that undergo thiol-specific bis-alkylation with the two cysteine sulphur atoms from a native accessible disulphide in proteins. The process for this approach of site-specific PEGylation involves t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e303a8832e7f4dfb89fc517b0474aadd
https://doi.org/10.1007/978-3-7643-8679-5_4
https://doi.org/10.1007/978-3-7643-8679-5_4