Tau protein binds to the P53 E3 ubiquitin ligase MDM2

Autor: Martina Sola, Azucena Rendon-Angel, Viviana Rojo Martinez, Jacopo Sgrignani, Claudia Magrin, Ester Piovesana, Andrea Cavalli, Paolo Paganetti, Stéphanie Papin

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Tau gene mutations cause a progressive dementia and neurotoxic Tau forms deposited in neurofibrillary tangles are hallmarks of neurodegenerative tauopathies. Loss of non-canonical Tau functions may contribute to disease. In fact, Tau depleti

Externí odkaz: https://doaj.org/article/8f761c052d23454f8cdfa0b6536595c4

Tau protein modulates an epigenetic mechanism of cellular senescence in human SH-SY5Y neuroblastoma cells

Autor: Claudia Magrin, Martina Bellafante, Martina Sola, Ester Piovesana, Marco Bolis, Luciano Cascione, Sara Napoli, Andrea Rinaldi, Stéphanie Papin, Paolo Paganetti

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Introduction: Progressive Tau deposition in neurofibrillary tangles and neuropil threads is the hallmark of tauopathies, a disorder group that includes Alzheimer’s disease. Since Tau is a microtubule-associated protein, a prevalent concept to expla

Externí odkaz: https://doaj.org/article/38cfccd2d5e4432fafa2b6cbdfe9a046

The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions

Autor: Maria Dolores Perez Carrion, Silvia Marsicano, Federica Daniele, Antonella Marte, Francesca Pischedda, Eliana Di Cairano, Ester Piovesana, Felix von Zweydorf, Elisabeth Kremmer, Christian Johannes Gloeckner, Franco Onofri, Carla Perego, Giovanni Piccoli

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Abstract Mutations in the Leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial Parkinson’s disease (PD). LRRK2 protein contains several functional domains, including protein-protein interaction domains at its N- and C-termini. In

Externí odkaz: https://doaj.org/article/80d9facf1fc1460aa75b5282c4e64bdf

Detection of tumor-derived extracellular vesicles interactions with immune cells is dependent on EV-labelling methods

Autor: Luisa Loconte, Davinia Arguedas, Anna Chipont, Rojbin El, Lea Guyonnet, Coralie Guerin, Ester Piovesana, José Luis Vázquez-Ibar, Alain Joliot, Clotilde Théry, Lorena Martín-Jaular

Cell-cell communication within the complex tumor microenvironment is critical to cancer progression. Tumor-derived extracellular vesicles (TD-EVs) are key players in this process. They can interact with immune cells and modulate their activity, eithe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7459de3d6b7c603d9f5e73d91870d00f
https://doi.org/10.1101/2023.01.04.522609

Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virus

Autor: Nicolas Manel, Clotilde Théry, Olivier Schwartz, Federico Cocozza, Nathalie Névo, Mercedes Tkach, Julian Buchrieser, Xavier Lahaye, Lorena Martin-Jaular, Ester Piovesana

Publikováno v: Journal of Extracellular Vesicles
Journal of Extracellular Vesicles, Taylor & Francis, 2020, 10 (2), ⟨10.1002/jev2.12050⟩
Journal of Extracellular Vesicles, Taylor & Francis, 2020, 10 (2), pp.e12050. ⟨10.1002/jev2.12050⟩
Journal of Extracellular Vesicles, 2020, 10 (2), pp.e12050. ⟨10.1002/jev2.12050⟩

International audience; SARS-CoV-2 entry is mediated by binding of the spike protein (S) to the surface receptor ACE2 and subsequent priming by host TMPRSS2 allowing membrane fusion. Here, we produced extracellular vesicles (EVs) exposing ACE2 and de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883d341cde6204e869b5d7f719fe81ab
https://hal.archives-ouvertes.fr/hal-03367539/document