Výsledky vyhledávání - "Ester M Weijers"

Akademický článek

A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants.

Autor: Sonja E M Boas, Joao Carvalho, Marloes van den Broek, Ester M Weijers, Marie-José Goumans, Pieter Koolwijk, Roeland M H Merks

Publikováno v: PLoS Computational Biology, Vol 14, Iss 7, p e1006239 (2018)

In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary scaffold formed during wound healing, the type and composition of fibrin impacts the level of sprouting. More sprouts form on high molecular weight (HMW) than on

Externí odkaz: https://doaj.org/article/f197f1914af8400786be1b39adc27ccc

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Akademický článek

HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells.

Autor: Tessa D Nauta, Monique C A Duyndam, Ester M Weijers, Victor M W van Hinsbergh, Pieter Koolwijk

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0160700 (2016)

During short-term hypoxia, Hypoxia Inducible Factors (particular their subunits HIF-1α and HIF-2α) regulate the expression of many genes including the potent angiogenesis stimulator VEGF. However, in some pathological conditions chronic hypoxia occ

Externí odkaz: https://doaj.org/article/64a9546ae5e0470da414d4893da81869

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Akademický článek

Correction: HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells.

Autor: Tessa D Nauta, Monique C A Duyndam, Ester M Weijers, Victor W M van Hinsbergh, Pieter Koolwijk

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0163840 (2016)

[This corrects the article DOI: 10.1371/journal.pone.0160700.].

Externí odkaz: https://doaj.org/article/6bdf9b7183004a9e9bfc4139805825fc

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Akademický článek

Extensive Characterization and Comparison of Endothelial Cells Derived from Dermis and Adipose Tissue: Potential Use in Tissue Engineering.

Autor: Hanneke N Monsuur, Ester M Weijers, Frank B Niessen, Amit Gefen, Pieter Koolwijk, Susan Gibbs, Lenie J van den Broek

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0167056 (2016)

Tissue-engineered constructs need to become quickly vascularized in order to ensure graft take. One way of achieving this is to incorporate endothelial cells (EC) into the construct. The adipose tissue stromal vascular fraction (adipose-SVF) might pr

Externí odkaz: https://doaj.org/article/9c6cc4da6c994cd690cbf7572e22bfc7

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Akademický článek

Long-Term Expansion in Platelet Lysate Increases Growth of Peripheral Blood-Derived Endothelial-Colony Forming Cells and Their Growth Factor-Induced Sprouting Capacity.

Autor: Dimitar Tasev, Michiel H van Wijhe, Ester M Weijers, Victor W M van Hinsbergh, Pieter Koolwijk

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129935 (2015)

Efficient implementation of peripheral blood-derived endothelial-colony cells (PB-ECFCs) as a therapeutical tool requires isolation and generation of a sufficient number of cells in ex vivo conditions devoid of animal-derived products. At present, li

Externí odkaz: https://doaj.org/article/d0b19da6947840c281476f38aa27c6a6

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Skin substitutes are more potent than dermal or epidermal substitutes in stimulating endothelial cell sprouting

Autor: Susan Gibbs, Ester M. Weijers, Hanneke N. Monsuur, Lenie J. van den Broek

Publikováno v: BMC Biomedical Engineering, Vol 1, Iss 1, Pp 1-7 (2019)
BMC Biomedical Engineering

Background Therapy resistant ulcers are wounds that remain open for a long time period and often arise from chronic venous disease, prolonged pressure or diabetes. For healing of chronic wounds, revitalization of the inert wound bed, which is achieve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd07e58d11ff1c4527a4c1398e69441
http://link.springer.com/article/10.1186/s42490-019-0018-8

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JNK2 in myeloid cells impairs insulin's vasodilator effects in muscle during early obesity development through perivascular adipose tissue dysfunction

Autor: Etto C. Eringa, Tom J. A. Kokhuis, Rick I. Meijer, John S Yudkin, Yvo M. Smulders, Femke P. M. Hoevenaars, Victor W.M. van Hinsbergh, Ester M Weijers, E.H. Serné

Publikováno v: Meijer, R I, Hoevenaars, F P M, Serné, E H, Yudkin, J S, Kokhuis, T J A, Weijers, E M, van Hinsbergh, V W M, Smulders, Y M & Eringa, E C 2019, ' JNK2 in myeloid cells impairs insulin's vasodilator effects in muscle during early obesity development through perivascular adipose tissue dysfunction ', American Journal of Physiology. Heart and Circulatory Physiology, vol. 317, no. 2, pp. H364-H374 . https://doi.org/10.1152/ajpheart.00663.2018
American Journal of Physiology-Heart and Circulatory Physiology, 317(2), H364-H374. American Physiological Society
American Journal of Physiology. Heart and Circulatory Physiology, 317(2), H364-H374. American Physiological Society

Reduced vasodilator properties of insulin in obesity are caused by changes in perivascular adipose tissue and contribute to microvascular dysfunction in skeletal muscle. The causes of this dysfunction are unknown. The effects of a short-term Western

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864db71855b445cfaaaa40c6386a8859
https://hdl.handle.net/1765/119068

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Matrix Remodeling and Osteogenic Differentiation of Human Adipose-Derived Stem Cells Increases with Higher Fibrin Matrix Stiffness

Autor: Thijs de Jong, Astrid D. Bakker, Pieter Koolwijk, Ester M. Weijers, Theo H. Smit

Publikováno v: de Jong, T, Weijers, E M, Bakker, A D, Koolwijk, P & Smit, T H 2016, ' Matrix remodeling and osteogenic differentiation of human adipose-derived stem cells increases with higher fibrin matrix stiffness ', Journal of Biomaterials and Tissue Engineering, vol. 6, no. 9, pp. 729-738 . https://doi.org/10.1166/jbt.2016.1494
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 6(9), 729-738. American Scientific Publishers
de Jong, T, Weijers, E M, Bakker, A D, Koolwijk, P & Smit, T H 2016, ' Matrix Remodeling and Osteogenic Differentiation of Human Adipose-Derived Stem Cells Increases with Higher Fibrin Matrix Stiffness ', JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, vol. 6, no. 9, pp. 729-738 . https://doi.org/10.1166/jbt.2016.1494
Journal of Biomaterials and Tissue Engineering, 6(9), 729-738. American Scientific Publishers

Introduction: Fibrin-matrices of different stiffness can be used for tissue engineering. The differentiation and extracellular matrix (ECM) remodeling properties of mesenchymal stem cells can be influenced by matrix stiffness. We hypothesized that st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31202ce49909084ecaaddd5374816631
https://doi.org/10.1166/jbt.2016.1494

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A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants

Autor: Pieter Koolwijk, Roeland M. H. Merks, Marloes van den Broek, João Carvalho, Marie-José Goumans, Ester M. Weijers, Sonja E. M. Boas

Publikováno v: PLoS Computational Biology, 14(7)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
PLoS Computational Biology, 14(7), e1006239
PLoS Computational Biology, Vol 14, Iss 7, p e1006239 (2018)
PLoS Computational Biology
Boas, S E M, Carvalho, J, van den Broek, M, Weijers, E M, Goumans, M-J, Koolwijk, P & Merks, R M H 2018, ' A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants ', PLoS Computational Biology, vol. 14, no. 7, e1006239 . https://doi.org/10.1371/journal.pcbi.1006239
PLoS Computational Biology, 14(7), e1006239. PUBLIC LIBRARY SCIENCE
PLoS Computational Biology, 14(7):e1006239. Public Library of Science

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3e0ca7f6be5c7254c7ced712782e51
https://hdl.handle.net/10316/81285

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Specific Effects of Fibrinogen and the γA and γ′-Chain Fibrinogen Variants on Angiogenesis and Wound Healing

Autor: Moniek P.M. de Maat, Bastiaan Tuk, Pieter Koolwijk, Reinilde Scheffer, Frank W.G. Leebeek, Johan W. van Neck, Ester M. Weijers, Elim Y. L. Cheung

Publikováno v: Tissue Engineering Part A, 21(1-2), 106-114. Mary Ann Liebert Inc.
Cheung, E Y L, Weijers, E M, Tuk, B, Scheffer, R, Leebeek, F W, van Neck, J W, Koolwijk, P & de Maat, M P M 2015, ' Specific Effects of Fibrinogen and the gamma A and gamma '-Chain Fibrinogen Variants on Angiogenesis and Wound Healing ', Tissue Engineering Part A, vol. 21, no. 1-2, pp. 106-114 . https://doi.org/10.1089/ten.tea.2014.0020

In a newly formed wound, the natural fibrin network provides the first temporary matrix for tissue repair. Topical application of fibrin to a new wound may improve wound healing. A matrix of the common natural gamma ' fibrin variant may further impro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b621ccad245ce8401c901cb0c980e360
https://doi.org/10.1089/ten.tea.2014.0020

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