Opposed Aromatic Surfaces Behave as Independent Binding Sites for Carbohydrate Stacking: Analysis of Sandwich-like CH/π/CH Complexes

Autor: Laura Díaz-Casado, Enrique Mann, Ester Jiménez-Moreno, Alejandro Villacampa, Laura Montalvillo-Jiménez, Claudia Sánchez-García, Francisco Corzana, Jesús Jiménez-Barbero, Ana María Gómez, Andrés G. Santana, Juan Luis Asensio

Publikováno v: JACS Au, Vol 4, Iss 11, Pp 4466-4473 (2024)

Externí odkaz: https://doaj.org/article/85f7c6f6bd204aecb6766b5c0f94911c

Stable Pyrrole‐Linked Bioconjugates through Tetrazine‐Triggered Azanorbornadiene Fragmentation

Autor: Enrique Gil de Montes, Alena Istrate, Claudio D. Navo, Ester Jiménez‐Moreno, Emily A. Hoyt, Francisco Corzana, Inmaculada Robina, Gonzalo Jiménez‐Osés, Antonio J. Moreno‐Vargas, Gonçalo J. L. Bernardes

Publikováno v: Angewandte Chemie. 132:6255-6259

An azanorbornadiene bromovinyl sulfone reagent for cysteine‐selective bioconjugation has been developed. Subsequent reaction with dipyridyl tetrazine leads to bond cleavage and formation of a pyrrole‐linked conjugate. The latter involves ligation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a95329f7e059fc84038e28db2d478b8
https://doi.org/10.1002/ange.201914529

Controlled In-Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging

Autor: Jason Day, Laura Rodríguez Pérez, Juraj Konč, Eloah Latocheski, Josiel B. Domingos, Ester Jiménez-Moreno, Valerio Sabatino, Gonçalo J. L. Bernardes

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
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© 2021 Wiley-VCH GmbH
Owing to their bioorthogonality, transition metals have become very popular in the development of biocompatible bond-cleavage reactions. However, many approaches require design and synthesis of complex ligands or formulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de001d4228d84b45405f9fd395acedc
https://pubmed.ncbi.nlm.nih.gov/34739737

Aromatic Interactions in Glycochemistry: From Molecular Recognition to Catalysis

Autor: Laura Díaz-Casado, Ester Jiménez-Moreno, Juan Luis Asensio, Andrés G. Santana, Laura Montalvillo, Enrique Mann

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Aromatic platforms are ubiquitous recognition motifs occurring in protein carbohydrate-binding domains (CBDs), RNA receptors and enzymes. They stabilize the glycoside/ receptor complexes by participating in stacking CH/π interactions with either the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44568067a36fae2de7fa8682d53ff300
https://pubmed.ncbi.nlm.nih.gov/34254906

Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment

Autor: Jesús H. Busto, Iris A. Bermejo, Elena M. Sánchez Fernández, Francisco Corzana, Carmen Ortiz Mellet, Hiroshi Hinou, Ramon Hurtado-Guerrero, José M. García Fernández, Shin-Ichiro Nishimura, Alberto Avenoza, Jorge Castro-López, Jesús M. Peregrina, Gonçalo J. L. Bernardes, Fayna Garcia-Martin, Ester Jiménez-Moreno, Claudio D. Navo, Ana Guerreiro

Publikováno v: Bermejo, I A, Navo, C D, Castro-López, J, Guerreiro, A, Jiménez-Moreno, E, Fernández, E M S, García-Martín, F, Hinou, H, Nishimura, S-I, Fernández, J M G, Mellet, C O, Avenoza, A, Busto, J H, Bernardes, G J L, Hurtado-Guerrero, R, Peregrina, J M & Corzana, F 2020, ' Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp 2-iminosugar fragment ', Chemical Science, vol. 11, no. 15, pp. 3996-4006 . https://doi.org/10.1039/c9sc06334j
Digital.CSIC. Repositorio Institucional del CSIC
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idUS. Depósito de Investigación de la Universidad de Sevilla
RIUR. Repositorio Institucional de la Universidad de La Rioja
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

This journal is © The Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d425b95d85347381933be4f1d2224897
https://curis.ku.dk/portal/da/publications/synthesis-conformational-analysis-and-in-vivo-assays-of-an-anticancer-vaccine-that-features-an-unnatural-antigen-based-on-an-sp2iminosugar-fragment(4b462479-354d-4598-a525-e622d8a47f80).html