Zobrazeno 1 - 10 of 38 pro vyhledávání: '"Ester Gonzalez-Sanchez"'
1
Akademický článek
Iron chelation as a new therapeutic approach to prevent senescence and liver fibrosis progression
Autor: Josep Amengual, Ania Alay, Javier Vaquero, Ester Gonzalez-Sanchez, Esther Bertran, Aránzazu Sánchez, Blanca Herrera, Kathleen Meyer, Mate Maus, Manuel Serrano, María Luz Martínez-Chantar, Isabel Fabregat
Publikováno v: Cell Death and Disease, Vol 15, Iss 9, Pp 1-13 (2024)
Abstract Iron overload and cellular senescence have been implicated in liver fibrosis, but their possible mechanistic connection has not been explored. To address this, we have delved into the role of iron and senescence in an experimental model of c
Externí odkaz: https://doaj.org/article/1102712af685433bb4149790f52627d9
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2
Akademický článek
Protective potential of the gallbladder in primary sclerosing cholangitis
Autor: Nora Cazzagon, Ester Gonzalez-Sanchez, Haquima El-Mourabit, Dominique Wendum, Dominique Rainteau, Lydie Humbert, Christophe Corpechot, Olivier Chazouillères, Lionel Arrivé, Chantal Housset, Sara Lemoinne
Publikováno v: JHEP Reports, Vol 5, Iss 4, Pp 100649- (2023)
Background & Aims: Gallbladder enlargement is common in patients with primary sclerosing cholangitis (PSC). The gallbladder may confer hepatoprotection against bile acid overload, through the sequestration and cholecystohepatic shunt of bile acids. T
Externí odkaz: https://doaj.org/article/4757adb6b76b4c48a591d51f829263ac
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3
Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis
Autor: Lin Lei, Alix Bruneau, Haquima El Mourabit, Justine Guégan, Trine Folseraas, Sara Lemoinne, Tom Hemming Karlsen, Bénédicte Hoareau, Romain Morichon, Ester Gonzalez‐Sanchez, Claire Goumard, Vlad Ratziu, Pierre Charbord, Jérémie Gautheron, Frank Tacke, Thierry Jaffredo, Axelle Cadoret, Chantal Housset
Publikováno v: Hepatology
Hepatology, In press, ⟨10.1002/hep.32456⟩
International audience; Background and Aims: In liver fibrosis, myofibroblasts derive from HSCs and as yet undefined mesenchymal cells. We aimed to identify portal mesenchymal progenitors of myofibroblasts.Approach and Results: Portal mesenchymal cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8bfa4349228cde993649f46f1f361d
https://doi.org/10.1002/hep.32456
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4
Zinc Finger E‐Box Binding Homeobox 1 Promotes Cholangiocarcinoma Progression Through Tumor Dedifferentiation and Tumor–Stroma Paracrine Signaling
Autor: Chantal Housset, Valérie Paradis, Corentin Louis, Ander Arbelaiz, Jesus M. Banales, Anna Pellat, Nathalie Guedj, Javier Vaquero, Cindy Lobe, Laura Izquierdo, Cédric Coulouarn, Ester Gonzalez-Sanchez, Marie Vallette, Laura Fouassier
Publikováno v: Hepatology. 74:3194-3212
Zinc finger E-box binding homeobox 1 (ZEB1) is a transcription factor that promotes metastatic and stem cell features, which has been associated with poor prognosis in cholangiocarcinoma (CCA), a desmoplastic cancer enriched in cancer-associated fibr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092db738a5b086ad3256000abf05b2f3
https://doi.org/10.1002/hep.32069
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7
Genetic alterations shaping tumor response to anti-EGFR therapies
Autor: Javier Vaquero, Allan Pavy, Ester Gonzalez-Sanchez, Mark Meredith, Ander Arbelaiz, Laura Fouassier
Publikováno v: Drug Resistance Updates. 64:100863
The Epidermal Growth Factor Receptor (EGFR) has been targeted through the development of selective tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAb). These molecules have shown effectiveness in a subset of patients with specific genet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e909d97b42e4ffec85e1552078f350b9
https://doi.org/10.1016/j.drup.2022.100863
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8
The TGF-β Pathway: A Pharmacological Target in Hepatocellular Carcinoma?
Autor: Javier Vaquero, Maite G. Fernandez-Barrena, Maria Reig, Pablo Sarobe, Isabel Fabregat, Matías A. Avila, Ester Gonzalez-Sanchez, Juan José Lasarte, Mariona Calvo
Publikováno v: Cancers, Vol 13, Iss 3248, p 3248 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
Cancers
Simple Summary Transforming Growth Factor-beta (TGF-β) signaling is crucial to maintain tissue homeostasis. Alterations in TGF-β signaling impact tissue functions and favor the development of diseases, including cancer. In hepatocellular carcinoma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6aaa009ec4023d4b08a5c49dc0a4994
https://www.mdpi.com/2072-6694/13/13/3248
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9
Cholangiopathy aggravation is caused by VDR ablation and alleviated by VDR-independent vitamin D signaling in ABCB4 knockout mice
Autor: Marie Clavel, Haquima El Mourabit, Marion Jager, Sophie Moog, Ester Gonzalez-Sanchez, Jérémie Gautheron, Tatiana Ledent, Chantal Housset, Laura Fouassier, Dominique Wendum, Axelle Cadoret, Javier Vaquero, Nicolas Chignard
Publikováno v: Biochimica et biophysica acta. Molecular basis of disease. 1867(4)
Background & aims Cholangiopathies are chronic liver diseases in which damaged cholangiocytes trigger a proinflammatory and profibrotic reaction. The nuclear vitamin D receptor (VDR) is highly expressed in cholangiocytes and exerts immune-regulatory
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb695dccf53857579d6a2944a3d2e8f
https://pubmed.ncbi.nlm.nih.gov/33418034
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10
Cold-atmospheric plasma induces tumor cell death in preclinical in vivo and in vitro models of human cholangiocarcinoma
Autor: Jérémy Augustin, Fatiha Merabtene, Javier Vaquero, Florian Judée, Ander Arbelaiz, Chantal Housset, Laura Fouassier, Ester Gonzalez-Sanchez, Marie Vallette, Henri Decauchy, Thierry Dufour, Olivier Scatton, Lynda Aoudjehane
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Cancers, Vol 12, Iss 1280, p 1280 (2020)
Cancers
Volume 12
Issue 5
Cancers, MDPI, 2020, 12 (5), pp.1280. ⟨10.3390/cancers12051280⟩
Through the last decade, cold atmospheric plasma (CAP) has emerged as an innovative therapeutic option for cancer treatment. Recently, we have set up a potentially safe atmospheric pressure plasma jet device that displays antitumoral properties in a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d712709a1d26868507cd4c8fcdbf7f3
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